На головну сторінку сайту Спрощенний режим E-бібліотека навчальних матеріалів
Авторизація
Прізвище
Пароль
 

Бази даних


Електронний каталог бібліотеки ЗДМФУ- результати пошуку

Вид пошуку
Електронний каталог бібліотеки ЗДМФУ
Каталог онлайн курсів на платформі edX
Публікації співробітників ЗДМФУ
Картотека авторефератів дисертацій
Картотека іноземної літератури
Картотека законодавчих документів
Картотека рідкісних видань
Фонд електронних документів
Каталог WEB - ресурсів
Ресурси порталу Springer Link (доступ через IP-адреси ЗДМУ)
Заочно-дистанційне навчання
Полнотекстовая
Зона пошуку
у знайденому
 Знайдено у інших БД:Публікації співробітників ЗДМФУ (17)Картотека іноземної літератури (17)
Формат представлення знайдених документів:
повнийінформаційнийкороткий
Відсортувати знайдені документи за:
авторомназвоюроком виданнятипом документа
Пошуковий запит: <.>II=ЗУ1/2018/20/3<.>
Загальна кількість знайдених документів : 30
Показані документи с 1 за 20
 1-20    21-30 
1.


   
    2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-,aryl-)-amines and their derivatives. Message 2. The synthesis of (3Н-quinazoline-4-ylidene)hydrazides N-protected aminoacids, using a variety of amine-protecting approaches. Physical-chemical properties and biological activity of synthesized compounds (Message 2) [Текст] / Yu. V. Martynenko [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 413-420 . - ISSN 2306-4145
MeSH-головна:
ТРИАЗОЛЫ (химический синтез)
ХИНАЗОЛИНЫ (химический синтез)
ГИДРАЗИНЫ (химический синтез)
СПЕКТРАЛЬНЫЙ АНАЛИЗ (использование)
Анотація: The synthetic potential of (3H-quinazoline-4-ylidene)hydrazides of carboxylic acids is significant in the context of new s-triazolo¬quinazolines creation and the obtained data of biological activity is a valid reason for the development of new methods of their synthesis, using a variety of reage nts. The introduction of N-protected aminoacids moieties into 4-hydrazinoquinazoline molecule is an important aspect, which solves this problem and extends the limits of hydrazides usage. The above would allow to change physical-chemical and biological properties of the corresponding hydrazides and it opens new perspectives of their practical application and further chemical transformations. The aim of the work is synthesis of unknown (3H-quinazoline-4-ylidene)hydrazides of N-protected aminoacids, using various approaches of the amino group protection, research of structure features and finding effective biologically active substances with antimicrobial and antiradical activities among them. Materials and methods. The individuality and structure of synthesized compounds was proved by elemental analysis, chromato¬mass- and 1H NMR spectra. In vitro research of antiradical activity was based on the interaction of synthesized compounds with 2,2-diphenyl-1-picrylhydrazyl (DPPH). The study of microbiological activity was conducted by serial dilution method on Mueller– Hinton broth on following strains of microorganisms and fungi: St. aureus ATCC 25923, E. coli ATCC 25922, P. aeruginosa ATCC 27853, C. albicans ATCC 885653. Conclusions. A synthetic method for (3H-quinazoline-4-ylidene)hydrazides N-protected aminoacids, which was based on interaction of 4-hydrazinoquinazoline with “activated” N-protected aminoacids was elaborated. It was found, that benzoyl- and Boc-aminoacids were the most reliable substrates for the synthesis of the corresponding hydrazides. A detailed analysis of 1H NMR spectra allowed the unambiguous establishing of peculiar to (3H-quinazoline-4-ylidene)hydrazides N-protected amino¬acids amid-imide tautomerism in DMSO solutions, due to the presence of hydrazide and amide groups. The microbiological screenings showed that hydrazides exhibited moderate antimicrobial activity against P. aeruginosa (MIC 50–100 μg/ml and MBC 100 μg/ml) and fungal activity against C. albicans (MIC 50 μg/ml, MBC 50–100 μg/ml). In addition, the synthesized compounds exhibited high antiradical activity, which indicated their prospects for further researches on other types of biological activity.


Дод.точки доступу:
Martynenko, Yu. V.; Kazunin, M. S.; Nosulenko, I. S.; Berest, G. G.; Kоvalenko, S. І.; Kamyshnyi, O. M.; Polishchuk, N. M.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
2.


   
    Adenovirus infection in adults: reactive response of polymorphonuclear neutrophilic leukocytes study [Текст] / V. D. Moskaliuk [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 339-343 . - ISSN 2306-4145
MeSH-головна:
АДЕНОВИРУСНЫЕ ИНФЕКЦИИ ЧЕЛОВЕКА (диагностика, кровь, лекарственная терапия, этиология)
НЕЙТРОФИЛЫ (иммунология)
МОНИТОРИНГ ИММУНОЛОГИЧЕСКИЙ (использование)
Анотація: The role of adenovirus infection in the SARS is significant but every year this group of infections makes up to 30 % of general infectious morbidity. Nowadays features of nonspecific immune defence in patients with adenovirus infection are insufficiently studied. Particularly acute AVI problem appears to clinicians and scientists as a contagious disease, which is rapidly spreading in organized collectives, among military personnel, students. Purpose. To study the reactive response of polymorphonuclear granulocytes in the peripheral blood of adult patients with ade-novirus infection. Materials and methods. 37 volunteers with SARS signs (Unified Protocol Criteria) were involved in this “case – control” type study. Absolute and relative quantities of the main immune cells populations in the peripheral blood were analyzed. Immunohematological indicators which characterize reactive response of the main non-specific immune cells were calculated. Clinical diagnosis was confirmed by the serological method of complement fixation test in paired sera and using adenoviruses common soluble complement-fixing antigen. Results. Neutrophil granulocytes reactivity increased by 83.92 % indicating these cells activation by cytokine system. The inflammatory process is accompanied by an increase in leukocytes absolute count – 19.76 %, band neutrophil leukocytes – in 2.18 times; lymphocytes – 30.30 % and monocytes – 48.15 %. Conclusions.Aforementioned means that there are different types of immune response to adenovirus infection antigens. Patients immune reactivity decreasing by 14.86 % means that specific immune response is formed later. Method of neutrophils reactive response evaluation can be used by practicing doctors for the early prediction of possible anti-infectious protection system alteration.


Дод.точки доступу:
Moskaliuk, V. D.; Balaniuk, I. V.; Sydorchuk, A. S.; Vozna, Kh. I.; Andruschak, M. O.; Rudan, I. V.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
3.


    Volkova, O. S.
    Analysis of changes in biochemical parameters of oral liquid under the influence of lecithin-calcium complex in young patients with multiple caries [Текст] / O. S. Volkova // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 375-378 . - ISSN 2306-4145
MeSH-головна:
КАРИЕС ЗУБОВ (диагностика, лекарственная терапия, этиология)
КАЛЬЦИЯ ЦИТРАТ (терапевтическое применение)
ЛЕЦИТИНЫ (терапевтическое применение)
Анотація: Given the high prevalence of dental caries, it is important to find new means and methods of prevention. At present preparationsof natural origin, such as lecithin and calcium citrate, are widely used. The aim was to study the lecithin-calcium complex effect on the oral fluid biochemical parameters of individuals with multiple dental caries. Materials and methods. 85 KhNMU Dental Faculty students-volunteers were examined. Groups of participants were formed depending on the dental caries intensity level index value for the oral fluid biochemical parameters determination (degree of oraldysbiosis, antioxidant-prooxidant index) in patients before and after the start of the lecithin-calcium complex treatment course. Results. In persons with multiple dental caries the degree of dysbiosis is 3 times higher than normal, the concentration of calcium decreases by 1.5 times and the antioxidant-prooxidant index reduces by 2 times. After lecithin-calcium complex treatment coursethe dysbiosis degree decreases almost by 8 times, the concentration of calcium and API return to normal. This indicates the abilityof the lecithin-calcium complex to regulate the oral cavity microbiocenosis and restore antioxidant-prooxidant indices. Conclusions. In patients with multiple dental caries the phenomena of the oral cavity dysbiosis, a decrease in the protective antioxidant system level and a decrease in the oral fluid calcium concentration are observed. The lecithin-calcium complexintake during the month completely eliminated the phenomenon of dysbiosis in the oral cavity, increased the antioxidant-pro-oxidant system level and the oral fluid calcium concentration to normal.

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
4.


   
    Anatomical optical, biomechanical and morphometric parameters of the eye in children with acquired myopia and syndrome of undifferentiated connective tissue dysplasia [Текст] / T. Ye. Tsybulskaya [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 392-396 . - ISSN 2306-4145
MeSH-головна:
МИОПИЯ (диагностика, лекарственная терапия, этиология)
СОЕДИНИТЕЛЬНОЙ ТКАНИ БОЛЕЗНИ (диагностика, лекарственная терапия, этиология)
ДЕТЕЙ ОХРАНЫ ЗДОРОВЬЯ СЛУЖБЫ
Анотація: Aim of the research – to make a comprehensive assessment of anatomical, optical, biomechanical and morphometric parameters of the eye in children with acquired myopia and syndrome of undifferentiated connective tissue dysplasia. Materials and methods. We examined patients of 2 groups: the I group – 44 children (88 eyes) with myopia of mild degree and phenotypic manifestations of connective tissue dysplasia, the II group – 40 patients (80 eyes) with myopia and without signs of connective tissue dysplasia. We measured the following parameters: corneal refractive power, corneal diameter and radius, thick¬ness of the cornea, anterior chamber depth, lens thickness, sagittal length of the vitreous body, axial length of the eye, corneal hysteresis, peripapillary retinal nerve fiber layer thickness. Results. We revealed significant differences in the anatomical, optical and biomechanical parameters of the visual analyzer in children with myopia of mild degree on the background of the UCTD, in contrast to children with myopia and without connective tissue dysplasia, which consisted in corneal refractive power reduction to an average of 41.25 [40.62; 41.75] D, increase in the corneal radius to an average of 8.13 [7.97; 8.28] mm, the corneal diameter to an average of 12.5 [12.1; 12.7] mm, the anterior chamber depth to an average of 3.8 [3.4; 4.0] mm, the sagittal length of the vitreous body to an average of 17.6 [17.3; 18.0] mm, the axial length of eye to an average of 24.9 [24.4; 25.4] mm, decrease in corneal hysteresis to an average of 11.2 [10.6; 11.7] mm Hg. Peripapillary retinal nerve fiber layer thickness was reduced to an average of 87 [85; 93] μm. Conclusions. The obtained data can be useful in a comprehensive assessment of ophthalmic manifestations of undifferentiated connective tissue dysplasia syndrome, in myopic process development prediction and in individual treatment tactics determination.


Дод.точки доступу:
Tsybulskaya, T. Ye.; Zavgorodnia, N. G.; Ivakhnenko, O. M.; Pashkova, O. Ye.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
5.


    Ivanko, O. G.
    Antibiotic-associated disorders of prothrombin synthesis and their probiotic correction with B. Clausii in breastfeed infants [Текст] / O. G. Ivanko, O. V. Solianyk // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 384-387 . - ISSN 2306-4145
MeSH-головна:
НОВОРОЖДЕННЫЙ, БОЛЕЗНИ (диагностика, история, лекарственная терапия, этиология)
ГРУДНОЕ ВСКАРМЛИВАНИЕ
ПРОТРОМБИНОВОЕ ВРЕМЯ (использование)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА (вредные воздействия, терапевтическое применение)
Анотація: The aim of the investigation was to study the prothrombin test and PIVKA-II serum levels changes in infants aged 1–6 month after the broad-spectrum antibiotic treatment and determine the possibility of coagulation disorders correction with the help of probiotic Bacillus clausii strains OC, NR, T, SIN spores capable to produce vitamin K2. Materials and methods. The study involved 57 convalescents after an acute respiratory infection exclusively breastfed infants aged 1 to 6 months one week after the 7-day parenteral treatment with ceftriaxone. Among them 13 children with laboratory signs of blood hypocoagulation (INR 1.3) had received probiotic Bacillus clausii spores in a daily dose of 2 × 109 CFU for 10 days. Another 13 children who had not received a probiotic made up a comparison group. Laboratory data was compared with the re¬sults of 27 healthy children of the control group. Prothrombin test parameters as a prothrombin (PT), prothrombin time (PTT), international normalized ratio (INR) and protein induced by vitamin K absence or antagonist II (PIVKA-II) were determined using the hematologic analyzer COAGUCHEC XS and ELISA kit. Results. It was found that after antibacterial treatment in infants PT was decreased and reached only 50 % of the norm. At the same time, PTT and INR were increased up to 2-folds together with a significant PIVKA-II elevation, which is typical for vitamin K de¬ficiency. The use of probiotic treatment within 10 days has contributed to normalization of prothrombin in 11 out of 13 observed infants versus 3 out of 13 in the comparison group (χ2 = 7.58 corrected by Yates, P 0.05). Conclusions. Cephalosporin administration for breastfed infants can lead them to latent vitamin K deficiency development, which is manifested by high levels of PIVKA-II and signs of hypocoagulation development revealed by prothrombin test. The Bacillus clausii probiotic spores prescription to infants after antibiotic therapy course for 10 days normalizes the plasma prothrombin concentration while in children of the comparison group it remains lower than normal.


Дод.точки доступу:
Solianyk, O. V.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
6.


    Chichirelo-Konstantynovych, K. D.
    Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course / K. D. Chichirelo-Konstantynovych // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 366-370 . - ISSN 2306-4145
MeSH-головна:
ПНЕВМОНИЯ (диагностика, лекарственная терапия, этиология)
ЦИТОМЕГАЛОВИРУС (действие лекарственных препаратов, патогенность)
АНТИТЕЛА (кровь)
Анотація: The article discusses the problem of cytomegaloviral persistence asymptomatic course among young patients with community-acquired pneumonia and in healthy population group based on specific immunoglobulins M and G appearance in blood andantibody avidity value (the duration of persistent). The connection between viral persistence and prognosis of community-acquiredpneumonia course (by pneumonia severity index in PORT) is also recognized. Aim of the scientific work is to study the prevalence of cytomegaloviral persistence among young patients with community-acquired pneumonia for optimization the plan of clinical examination and prognosis for this patient category. Materials and methods. One hundred and five patients with community-acquired pneumonia and 61 healthy individuals (aged from 18 to 44 years) were examined for cytomegaloviral biomarkers (CMV IgG, CMV IgG avidity) and by PORT-scale. Positiveresult for viral persistence was compared with gender, age subtypes and pneumonia severity index in both groups. Results. Cytomegaloviral persistence prevalence rate among patients with community-acquired pneumonia was 48.2 % versus 20.5 % among healthy individuals (P = 0.003). The patients with community-acquired pneumonia had higher CMV IgG avidityvalue (P = 0.007), it was more common for female patients (P = 0.043; χ2 = 8.164). The cytomegaloviral persistence prevalenceincreased with age (P = 0.045) and correlated with pneumonia severity index according to PORT-scale (P ‹ 0.0001). Conclusions. The patients with community-acquired pneumonia differ in significantly higher cytomegaloviral prevalence rate (P = 0.003) from the healthy respondents. This rate increases with age, negatively impacts the pneumonia prognosis (byPORT-score). The duration of cytomegaloviral persistence (based on the CMV IgG avidity value recognition) does not dependon age in both comparison groups (P › 0.05).

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
7.


    Matsuga, O. M.
    Computational technology of daily blood pressure monitoring results comparison in patients with arterial hypertension [Текст] / O. M. Matsuga, I. V. Drozdova, A. K Akimova // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 309-314 . - ISSN 2306-4145
MeSH-головна:
КРОВЯНОГО ДАВЛЕНИЯ МОНИТОРИНГ АМБУЛАТОРНЫЙ (использование)
ГИПЕРТЕНЗИЯ (диагностика, лекарственная терапия, этиология)
СТАТИСТИКА НЕПАРАМЕТРИЧЕСКАЯ
Анотація: The evaluation of treatment effectiveness and further patient with arterial hypertension (AH) monitoring require the target level of arterial pressure achievement and its control by means of daily monitoring of blood pressure (DMBP). Purpose of the work involves development, software implementation and practical approval of computational technology in order to compare the results of patient’s two daily monitoring of blood pressure. Material and methods. The open controlled study included 10 patients with AH at the third stage in long term after a cerebral stroke. Patients were treated according to the regulatory basis. DBPM was conducted using device АВРМ-01 (Meditech, Hungary) twice (before the treatment and after 1 year). Results comparison of the first and repeated DMBP was carried out by means of proposed computational technology and its own software ArtHyper in which the technology was implemented. The technology is based on the comparison of DMBP indices distribution functions using the two-sample Kolmogorov test and the Wilcoxon test. Results. The proposed technology work was demonstrated in terms of two patients. The target level of arterial pressure was achieved only for the first patient. The majority of DMBP indices distribution for this patient did not change in a year, in other words, the blood pressure and heart rate remained stable due to the treatment. The level of PBP slightly decreased, but in this case it was a positive factor. The second patient didn’t follow the complete course of treatment and didn’t achieve the target level of blood pressure. His levels of diastolic blood pressure and heart rate increased. Conclusions. The computational technology of two patient’s DMBP results comparison was developed. Its practical testing was carried out on real data and demonstrated the effectiveness of technology to detect changes in the second results monitoring and the possibility of its application for the evaluation of rehabilitation and treatment efficiency in patients with arterial hypertension.


Дод.точки доступу:
Drozdova, I. V.; Akimova, A. K
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
8.


    Ananieva, M. M.
    Etiological and pathogenetic aspects of non-specific bacterial vaginosis [Текст] / M. M. Ananieva // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 432-436 . - ISSN 2306-4145
MeSH-головна:
ВАГИНИТ БАКТЕРИАЛЬНЫЙ (диагностика, лекарственная терапия, микробиология, этиология)
БАКТЕРИИ АНАЭРОБНЫЕ (патогенность)
ЖЕНСКИЕ БОЛЕЗНИ (диагностика, лекарственная терапия, микробиология, этиология)
Анотація: The aim of this review was the biological properties analysis of microorganisms known as the main contributors to the non-specific bacterial vaginosis development.The mechanisms of anaerobic vaginal microflora pathogenic action have been found out to be the main cause of non-specificinflammatory processes. Special attention was given to the genera of Mobilunkus spp., Atopobium spp., Prevotella sp. represen-tatives, which were studied as vaginal flora due to the modern diagnostic methods and techniques development.The homeostasis of the vaginal ecosystem results from complex interactions and synergies among the host and different microor-ganisms that colonize the vaginal mucosa and healthy vaginal microbiota is generally dominated by Lactobacillus spp. Lactobacilliwhich have been known to be antagonistic toward a variety of microorganisms.In cases of bacterial vaginoses, the proportion of Lactobacilus spp sharply decreases, while the share of anaerobic microorganismsincreases: Gardnerella vaginalis, Atopobium sp., Mobiluncus sp., Prevotella sp. The virulence factors of Gardnerella vaginalispathogenicity are: its ability to form biofilms; the presence of genes responsible for cytotoxicity.The ability of Gardnerella vaginalis, Atopobium sp., Mobiluncus sp., Prevotella sp. to produce short chain volatile fatty acidsisomers results in the vaginal mucosa irritation (itching or burning) and discharge with unpleasant odour in BV associated withthese microorganisms.Atopobium vaginae, together with Mobiluncus spp. and Prevotella spp., provoke the accumulation of pro-inflammatory cytokines.The whole mechanism leads to an inflammation worsening in BV and stimulates the chronic process development.Both microorganisms Mobiluncus spp. and A. vaginae are competitive lactobacilli in relation to the glycogen consumption. Conclusions.Analysis of literature shows that pathogens of non-specific bacterial vaginosis have wide range of pathogenicity factors. This provides pathogenesis and clinical signs of the disease.

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
9.


    Raznatovska, O. M.
    Factors of chemoresistant pulmonary tuberculosis progression in patients receiving palliative treatment [Текст] / O. M. Raznatovska, G. V. Khudyakov // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 388-391 . - ISSN 2306-4145
MeSH-головна:
ТУБЕРКУЛЕЗ, МНОЖЕСТВЕННАЯ ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ (диагностика, лекарственная терапия, этиология)
ПАЛЛИАТИВНАЯ МЕДИЦИНСКАЯ ПОМОЩЬ (использование)
НОВООБРАЗОВАНИЙ НЕКРОЗА ФАКТОРЫ
КАЧЕСТВО ЖИЗНИ
ТЕЛА МАССЫ ИНДЕКС
Анотація: Objective – to define factors of chemoresistant pulmonary tuberculosis (CRPTB) progression in patients receiving palliative treatment by means of their QL, TNF-α levels and body mass index complex assessment. Materials and methods. 81 CRPTB patients were examined and divided into two groups: the main group consisted of 52 patients receiving palliative treatment and the control group consisted of 29 patients receiving antimycobacterial therapy by category 4 according to drug resistance. The MOS SF-36 questionnaire was used to evaluate the quality of life. Studies of serum TNF-α level were determined by enzyme-linked immunosorbent assay using immunoenzymometric reader Sirio S and a set “Bender MedSys¬tems GmbH” (Austria), (pg/ml). Body mass index was calculated with the help of calculator New BMI (New Body Mass Index), (kg/m2). Results of this study were processed using the modern methods of analysis with the help of a personal computer and the statistical package of the licensed software program Statistica® for Windows 6.0 (StatSoft Inc., № AXXR712 D833214FAN5). Results. CRPTB patients receiving palliative treatment have simultaneously a high activity of inflammatory specific process, predomi¬nant body mass deficit and low quality of life (both its physical and mental component). And along with this in patients receiving CRPTB treatment, activity of specific inflammatory process is 2.2 times lower, normal level of body weight predominate and quality of life is satisfactory (with satisfactory levels of both its components). Assessment of correlation relationships gave an opportunity to find out that in CRPTB patients, receiving palliative treatment, absence of the specific process antimycobacterial therapy leads to an increase in blood serum TNFα which in its turn promotes development of body mass deficit and as a consequence quality of life is decreased through decrease of all its components. In patients receiving etiotropic treatment activity of specific inflammatory process promotes decrease of body mass and quality of life but these changes are not so expressed as in case with patients receiving palliative treatment. Conclusions. Factors of CRPTB progression in patients receiving palliative treatment include increase of TNFα level in the blood serum (≥180 pg/ml), deficit in body mass (≤18.1 kg/m2), decrease in quality of life index (≤50 relative units).


Дод.точки доступу:
Khudyakov, G. V.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
10.


   
    Gastric duplication in infants [Текст] / O. V. Spakhi [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 443-447 . - ISSN 2306-4145
MeSH-головна:
ЖЕЛУДОК (аномалии, патология, хирургия)
АНОМАЛИИ ВРОЖДЕННЫЕ (диагностика, хирургия)
ДЕТЕЙ ОХРАНЫ ЗДОРОВЬЯ СЛУЖБЫ
Анотація: Clinicians pay close attention to the questions related to the diagnosis and treatment tactics of stomach defects with its obstruction in view of their stable frequency and lack of consensus on these diseases development mechanisms. The insufficient individual experience of every clinician leads to the difficulties in early diagnostic and the most adequate surgical intervention choice, and so, high rates of mortality. Purpose of the work. Improvement of the diagnostic and treatment tactic in infants with gastric duplication. Materials and methods. Clinical experience of two cases of the newborn children treatment with rare variants of digestive tract developmental defects is presented. In one child it was a case of stomach cystic duplication; and the other had a cystic duplication of stomach and duodenum. Results. There have been 5 cases of the stomach duplication treatment in the last 5 years in the Pediatric Surgery Clinic of Zaporizhzhia State Medical University. Two children were diagnosed with this pathology in neonatal period. Clinical analysis of these cases is described in the article. Both infants have undergone the early operative intervention. Type and extent of the operation depended on the peculiarities of localization, sizes, clinical signs of the defects and the general state of patients. The main stages and methods of medical-diagnostic process of such patients’ management are presented. Conclusions. The analysis shows that the efficacy of stomach obstruction rare forms diagnosis is achieved by usage of algorithms based on the staged modern diagnostic methods, taking into account their resolution and congenital anomaly type. In congenital stomach and duodenum duplication maximal informativness can be achieved using ultrasound and CT (or MRI) of the abdominal cavity. The most effective and non-invasive is ultrasound method by high-resolution devices. The discussed clinical cases are examples of early diagnosis of the stomach duplication and the right choice of active tactics for such children management that has made it possible to obtain a successful treatment outcome.


Дод.точки доступу:
Spakhi, O. V.; Liaturynska, O. V.; Makarova, М. О.; Anikin, I. O.; Zaporozhchenko, A. H.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
11.


    Shcherbyna, R. О.
    Histological study of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate (PKR-173) corrective influence on the chickens liver state in the condition of tetracycline hepatitis [Текст] / R. О. Shcherbyna, Ye. V. Vashchyk // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 404-412 . - ISSN 2306-4145
MeSH-головна:
ГЕПАТИТ (диагностика, лекарственная терапия, этиология)
ТЕТРАЦИКЛИНЫ (вредные воздействия)
ТРИАЗОЛЫ (терапевтическое применение)
ИММУНОГИСТОХИМИЯ (использование)
Анотація: Despite great scientific progress in the sphere of hepatoprotectors development during recent years, the issues of hepatocytes protection and regeneration is relevant enough. In this aspect derivatives of heterocyclic systems are of great interest, in particular, of 1,2,4-triazole. The aim is histological study of the compound of potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate (PKR-173) corrective influence on the chickens liver under tetracycline hepatitis condition. Materials and methods. As an object of research potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio) acetate was used which is a water-soluble compound. Histological examination was carried out of the intact chickens liver (intact control); of the chickens after tetracycline administration (control pathology); of the chickens which before the administration of tetracycline were administrated PKR-173 compound or thiotriazoline. All chickens were administrated tetracycline per os in the doze of 500 mg/kg for 5 days. PKR-173 compound and thiotriazoline were administrated per os for 3 days before tetracycline in doze of 150 mg/kg and 50 mg/kg respectively. Results. It has been noted that preventive administration of PKR-173 compound for chickens aged 7–18 days visually prevented the development of nonspecific morphological changes which are characteristic of acute moderately severe drug-induced bird’s liver injury. Compound PKR-173 contributed the organ histostructure normalization, prevented dystrophy manifestations, significantly reduced necrosis of hepatocytes and inflammatory reaction in the perivenular zone of triad system. Comparative drug thiotriazoline prevented hepatocytes dystrophy manifestation, in the vast majority of chickens contributed to hepatic plates structure restoration and inflammatory response reduction. In order to confirm the visual data according to the task, a semi-quantitative assessment of the PKR-173 and thiotriazoline corrective effect on chickens liver parenchyma morphological state was carried out. Conclusions. Analysis of the pathological process quantitative characteristics, which developed in the chicken liver after tetracycline administration and corrective influence of the investigated drugs on it, has shown that the PKR-173 compound significantly reduced the manifestations of all the pathological features detected for testing compared to control pathology. The PKR-173 compound is probably not inferior to comparative drug thiotriazoline by normalizing effect on the organ histostructure restoration and antidystrophic action intensity. The PKR-173 compound significantly outperforms the comparative thiotriazoline for anti-necrotic and anti-inflammatory effects.


Дод.точки доступу:
Vashchyk, Ye. V.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
12.


   
    Macro- and microelements determination in children with rotavirus infection [Текст] / O. I. Smiyan [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 371-374 . - ISSN 2306-4145
MeSH-головна:
РОТАВИРУСНЫЕ ИНФЕКЦИИ (диагностика, лекарственная терапия, этиология)
МИКРОЭЛЕМЕНТЫ (анализ, кровь)
ДЕТЕЙ ОХРАНЫ ЗДОРОВЬЯ СЛУЖБЫ
Анотація: The purpose of this study was to determine serum zinc, iron, magnesium, copper, potassium, calcium, and sodium levels in acute rotavirus infection and convalescence period in children. Materials and methods. We examined 86 patients aged from 4 months to 5 years with clinical and laboratory signs of rotavirus infection. The I group – 43 children with RVI in acute period. The II group – 43 children with RVI in convalescence period. Thecontrol group included 14 healthy children at the same age. The content of macro- and microelements (zinc, iron, magnesium,copper, potassium, calcium and sodium) in blood serum was determined by atomic absorption spectrophotometry. Feces sampleswere used for Cito Test Rota (Pharmasco). Cito test was used for rotavirus antigen detection in feces. Statistical analysis wasperformed by Excel. Student’s t-test was used to evaluate differences between study groups. Results. The acute period of the disease in children with rotavirus infection was characterized by a significant increase of copper in blood serum compared with the control group. At the same time, a significant decrease of iron, magnesium, zinc, potassium,calcium, sodium were determined in patients with rotavirus infection, compared with apparently healthy children. After standardtreatment only the indicators of magnesium, potassium and sodium reached the same indices of control group children. Conclusions. The detected changes in the mineral status of patients with rotavirus infection suggest the need for treatment correction. Correction of micro- and macroelements imbalances in patients with rotavirus infection possibly should be aimed atthe metallo-drugs inclusion in complex treatment as well as medicines which improve absorption of the latter in the intestine.


Дод.точки доступу:
Smiyan, O. I.; Smiyan-Horbunova, K. O.; Loboda, A. M.; Popov, S. V.; Bynda, T. P.; Vysotsky, I. Yu.; Sichnenko, P. I.; Petrashenko, V. O.; Man'ko, Yu. A.; Kosarchuk, V. V.; Gordienko, O. V.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
13.


   
    Neuron specific enolase as a possible indicator of neuron damage in children with acute meningitis [Текст] / L. V. Pypa [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 354-358 . - ISSN 2306-4145
MeSH-головна:
МЕНИНГИТ (диагностика, лекарственная терапия, этиология)
ЕНОЛАЗА (анализ)
ДЕТЕЙ ОХРАНЫ ЗДОРОВЬЯ СЛУЖБЫ
Анотація: Acute meningitis in children is a common cause of complications and leads to developmental disabilities. That is the reason why it is important to look for possible markers that indicate nerve tissue damage for early diagnosis, their prevention and prognosisof CNS complications. Objective. To examine neuron specific enolase (NSE) and its diagnostic significance as an indicator of neuronal damage in children with acute meningitis. Materials and methods. Blood samples of 40 children with acute meningitis and 30 of healthy children between the ages of 1 month to 18 years old were studied. The measurement of NSE was made from a blood serum during the first 24 hours after hospitalization by the enzyme-linked immunosorbent assay test performing. The degree of impaired consciousness was determined by the Glasgow Coma Scale. The results were processed with the Student’s t-test, correlation and regression analysis methods with constructing confidence intervals. Results. NSE levels in children with acute meningitis was 7.6 times higher than the results of healthy children, which was 22.56 ± 1.14 and 2.95 ± 0.16 ng/ml, respectively, (P 0.0001) (95 % CI; 19.19 to 20.03). CNS complications of the disease in patients were detected in 22 (55 %). Patients with complications had significantly higher level of NSE than patients without complications and it was 25.35 ± 1.61 and 18.60 ± 1.49 ng/ml, respectively, (P 0.01) (95 % CI; 5.74 to 7.75). Impaired consciousness was observed in 21 (52.5 %) patients. The content of NSE in patients with impaired consciousness was within 20.72 ± 7.33 ng/ml and it was higher than NSE content in patients with normal consciousness that was within 16.56 ± 4.69 ng/ml (P 0.05) (95 % CI; 0.17 to 8.14). Reliable inverse and strong correlation was detected between the NSE level and the level of consciousness by the Glasgow Coma Scale, where the coefficient of determination R2


Дод.точки доступу:
Pypa, L. V.; Svistilnik, R. V.; Moskovko, G. S.; Lysytsia, Yu. M.; Murhina, M. M.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
14.


    Kuznietsov, A. A.
    Predicion of the functional outcome of cerebral ischemic supratentorial stroke acute period on the basis of spectral analysis of the brain bioelectrical activity / A. A. Kuznietsov // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 324-329 . - ISSN 2306-4145
MeSH-головна:
МОЗГА ГОЛОВНОГО ИНФАРКТ (диагностика, лекарственная терапия, этиология)
МОЗГА ВОЛНЫ (физиология)
ПРОГНОЗ
Анотація: The purpose of this study was to determine the most informative parameters of the brain bioelectrical activity spectral analysis for the functional outcome of cerebral ischemic supratentorial stroke (CISS) acute period prediction. Materials and methods. Prospective, cohort and comparative study was conducted among 103 patients in CISS acute period (61 men and 42 women, mean age was 67.7 ± 0.8 years). Electroencephalographic study was conducted on the 2nd–3rd day of the disease with the use of 19-channel electroencephalographic scanner. The values of absolute spectral rhythm power of delta (0.5–4.0 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (13–35 Hz), theta1 (4–6 Hz), theta2 (6–8 Hz), alpha1 (8–10 Hz), alpha2 (10–13 Hz), beta1 (13–25 Hz) and beta2 (25–35 Hz) bands in the affected hemisphere (AH) and intact hemisphere (IH) were determined. The relative spectral rhythm power (RSRP), fronto-occipital rhythm gradient (FORG) and the severity of interhemispheric rhythm asymmetry (IHRA) were calculated. The functional outcome of the disease acute period was assessed on the 21st day on the basis of the modified Rankin Scale (mRS), while the value of mRS score 3 was considered as an unfavourable functional outcome. Results. Unfavourable functional outcome of the CISS acute period was registered in 46 (44.6 %) patients. In accordance with the data of multivariate regression analysis it was determined that RSRP of delta band in the IH (OR 95 % CI = 1.31 (1.13–1.52), P = 0.0004), FORG of alpha band in the AH (OR 95 % CI = 29.07 (1.86–455.15), P = 0.0224) and IHRA of alpha band (OR 95 % CI = 0.01 (0.0001–0.80), P = 0.0402) were independently associated with functional outcome of the CISS acute period. The RSRP of delta band in the IH › 18.4 % (Se = 87.0 %, Sp = 87.7 %, AUC 95 % CI = 0.94 (0.87–0.98), P ‹ 0.0001), FORG of alpha band in the AH ›-0.066 (Se = 67.4 %, Sp = 70.0 %, AUC 95 % CI = 0.74 (0.65–0.82), P‹0.0001) and IHRA alpha band ≤-0.066 (Se = 60.9 %, Sp = 70.2 % AUC 95 % CI = 0.66 (0.56–0.75), P ‹ 0,0039) were the optimal cut-off values as for the unfavourable functional prognosis of CISS acute period. Conclusions. The RSRP of delta band in the IH, FORG of alpha band in the AH and the IHRA of alpha band are the most informative parameters of the brain bioelectrical activity spectral analysis for the prediction of the functional outcome of cerebral ischemic supratentorial stroke acute period.

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
15.


    Lezhenko, G. O.
    The approaches to prevention and therapy of cardiovascular disorders in children with chronic bronchopulmonary pathology [Текст] / G. O. Lezhenko, O. Ye. Pashkova // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 359-365 . - ISSN 2306-4145
MeSH-головна:
КИСТОЗНЫЙ ФИБРОЗ (диагностика, лекарственная терапия, этиология)
ЛЕГКИХ БОЛЕЗНИ (диагностика, лекарственная терапия, этиология)
АСТМА БРОНХИАЛЬНАЯ (диагностика, лекарственная терапия, этиология)
АРГИНИН (анализ)
КАТАМНЕСТИЧЕСКИЕ ИССЛЕДОВАНИЯ
СЕРДЦА ЖЕЛУДОЧКА РЕМОДЕЛИРОВАНИЕ (действие лекарственных препаратов)
ДЕТЕЙ ОХРАНЫ ЗДОРОВЬЯ СЛУЖБЫ
Анотація: The purpose of this study was to develop and evaluate the algorithm for cardiovascular disorders prevention and therapy effec¬tiveness in children with chronic bronchopulmonary pathology. Materials and methods. There was catamnestic examination of 57 patients with chronic bronchopulmonary pathology (29 chil¬dren with severe, controlled or partially controlled persistent bronchial asthma and 28 children with cystic fibrosis and pancreatic insufficiency) who were analyzed the dynamics of left ventricular myocardial remodeling, depending on the administrated treat¬ment. Catamnesis duration was 1 year. The average age of children in the observation group was 9.2 ± 0.6 years. The ultrasound examination of the heart was performed using the Medison SonoAce 8000 ultrasound machine (USA) according to the standard procedure. The mathematical analysis and statistical processing of data were performed on a PC using the licensed software package of Statistic for Windows 10.RU using variation, correlation, regression and nonparametric methods of statistical analysis. Variables were expressed as M ± m and P value 0.05 was considered to indicate statistical significance. Results. It has been established that there is a structural and functional left ventricular myocardium rearrangement on the background of left ventricular diastolic dysfunction development, sympathetic branch of the autonomic nervous system functional impairment, myocardium electrical instability and endothelium-depended vasodilation disturbance in children with chronic bronchopulmonary diseases. The algorithm has been worked out for choosing tactics of cardiovascular disorders therapy based on the study results, which is a complex of non-medicamentous and medicamentous methods with drug modulators of “L-arginine – nitric oxide” sys¬tem – ACE and L-arginine inhibitors inclusion in the therapy. The effectiveness of proposed algorithm was estimated in 27 children with chronic bronchopulmonary diseases. The other 30 patients, who were treated with traditional therapy, made up a comparison group. It has been found that proposed therapeutic method application in the complex treatment of children with chronic broncho¬pulmonary pathology contributed to left ventricular myocardium morphofunctional state improvement by slowing processes of left ventricular remodeling and increasing the number of patients who had normal left ventricular myocardium geometry. There was a progression of the left ventricle morphofunctional state changes in the comparison group, which was manifested by an increase in the left ventricular myocardium mass and structural-geometric myocardial restructuring by concentric type of cardiac remodeling. Conclusions. The use of proposed algorithm can prevent cardiovascular disorders progression and provide more effective rehabilitation of children with chronic bronchopulmonary diseases.


Дод.точки доступу:
Pashkova, O. Ye.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
16.


    Kravchenko, T. V.
    The search for new 4-amino-5-methyl-4H-1,2,4-triasole-3-thion derivatives with diuretic activity [Текст] / T. V. Kravchenko // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 421-424 . - ISSN 2306-4145
MeSH-головна:
ТРИАЗОЛЫ (терапевтическое применение, химический синтез)
ДИУРЕТИКИ (терапевтическое применение, химический синтез)
Анотація: 1,2,4-Triazole derivatives have been widely used in medical practice due to their wide spectrum of biological activities and low toxicity, as they have 1,2,4-triazole cycle in their structure. That makes 1,2,4-triazole derivatives a very promising and attractive class of organic compounds in research of their physical and chemical properties, and biological activity determining. In order to find new substances with potential biological activity 20 new compounds of 4-amino-5-methyl-4H-1,2,4-tiazole-3-thion derivatives were synthesized, which have never been described in literature before. The objective of this study was the research of bioactivity of 4-amino-5-methyl-4H-1,2,4-tiazole-3-thion derivatives. Materials and methods. Compounds of research were synthesized in Department of Toxicological and Inorganic Chemistry of ZSMU. Berchin method was used in order to estimate the effect of compounds on excretory function of kidneys. Results. Diuretic activities of 4-amino-5-methyl-4H-1,2,4-tiazole-3-thion derivatives were studied. The compounds exhibit both diuretic and antidiuretic effects. It is worth noting that 4-((R-idene)amino)-5-methyl-4H-1,2,4-triazole-3-thion derivatives demonstrated both moderate and high diuretic activity. In such way, introduction of 3,4-methoxybenzyl, 3,5-methoxybenzyl and 2-chloro-6-flu¬orobenzyl substituents into the structure of 4-((R-idene)amino)-5-methyl-4H-1,2,4-triazole-3-thion slightly increased diuretic effect. Reduction of compounds 4-((4-bromobenzylidene)amino)-5-methyl-4H-1,2,4-triazole-3-thion, 5-methyl-4-((thiophen-2-yl¬methylene)amino)-4H-1,2,4-triazole-3-thion, 4-((2-chloro-6-fluorobenzylidene)amino)-5-methyl-4H-1,2,4-triazole-3-thion caused decline of diuretic activity. The most potent bioactivity was observed in 4-((4-methoxybenzyl)amino)-5-methyl-4H-1,2,4-triazole- 3-thion. Conclusion. Derivatives of 4-amino-5-methyl-4H-1,2,4-tiazole-3-thion exhibit both diuretic and antidiuretic effects. “Structure – еf-fect” relation was shown. The most potent activity was observed in 4-((4-methoxybenzyl)amino)-5-methyl-4H-1,2,4-triazole-3-thion.

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
17.


   
    Trіazolo[1,5-c]quіnazolіnes Synthesis, antimicrobial and antifungal activity [quinazolin-4(3H)-ylidene]hydrazides of carboxylic acids (Message 1) [Текст] / K. P. Schabelnyk [et al.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 425-431 . - ISSN 2306-4145
MeSH-головна:
ТРИАЗОЛЫ (терапевтическое применение, химический синтез)
ПРОТИВОГРИБКОВЫЕ СРЕДСТВА (химический синтез)
АНТИБАКТЕРИАЛЬНЫЕ СРЕДСТВА (химический синтез)
Анотація: The modern standards and algorithms of antimicrobial therapy, that ensure a high level of the treatment’s quality and prevention of the most infectious-inflammatory diseases, provide wide using of chemotherapeutic agents. However, the modern medicines do not always have satisfactory chemotherapeutic and pharmacological properties; this fact is most often associated with the re¬sistance of microorganisms to them. That is why the creation of the new chemotherapeutic drugs by natural antibiotics’ chemical and microbiological modification, the chemical synthesis of the new substances among the various classes of organic compounds is a topical problem. The aim of the study is the developing of simple and accessible methods for the synthesis of new [quinazoline-4(3H)-ylidene] hydrazides of cycloalkyl-(hetaryl) carboxylic acids, analysis of their physical-chemical properties, antimicrobial and antifungal activity. Materials and methods. The study of the antimicrobial activity of synthesized compounds was carried out by the method of two-fold serial dilutions in the Mueller Hinton broth (for strains Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) and in the Saburo broth (for Candida albicans ATCC 885-653). Minimal inhibitory con¬centration, minimal bactericidal and fungicidal concentration were defined. Results. It was found that synthesized compounds show antimicrobial and antifungal activity to researched strains. Conclusions. There have been considered a number of preparative methods for the synthesis of [quinazoline-4(3H)-ylidene] hydrazides of cycloalkyl-(hetaryl)carboxylic acids, which are significant as chemical reagents for the preparation of condensed heterocyclic and biologically active compounds. The structure and individuality have been proved by elementary analysis and physical-chemical methods (1H NMR-spectroscopy, HPLC/MS). The antimicrobial analysis shows that N’-[quinazoline-4(3H)- ylidene]-2(3)-heteril hydrazides containing a pyridinecarboxylic acid residue in the molecule have the highest activity, which exceeds the activity of the reference standard “Trimethoprim”. N’-(6-bromohinazolin-4(3H)-ylidene)benzofuryl-2-carbohydrazide demonstrates the highest antifungal activity, which is comparable with the reference standard “Ketoconazole”.


Дод.точки доступу:
Schabelnyk, K. P.; Kholodnyak, S. V.; Berest, G. G.; Kоvalenko, S. І.; Polishchuk, N. M.; Kamyshnyі, O. M.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
18.


    Волошин, О. М.
    Взаємозв’язок нейтрофіл-лімфоцитарного співвідношення та хронічної ішемії нижніх кінцівок [Текст] / О. М. Волошин // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 330-333 . - ISSN 2306-4145
MeSH-головна:
АРТЕРИОСКЛЕРОЗ ОБЛИТЕРИРУЮЩИЙ (диагностика, диетотерапия, лекарственная терапия, этиология)
АРТЕРИЙ ОККЛЮЗИРУЮЩИЕ БОЛЕЗНИ (диагностика, лекарственная терапия, этиология)
КОНЕЧНОСТЬ НИЖНЯЯ (кровоснабжение, патология)
Анотація: Мета роботи – вивчити особливості нейтрофіл-лімфоцитарного співвідношення (НЛС) у хворих на хронічну ішемію нижніх кінцівок. Матеріали та методи. Протягом проспективного дослідження проаналізували показники НЛС у 282 пацієнтів із перифе¬ричними артеріальними оклюзіями. Усіх хворих поділили на 4 групи згідно з класифікацією атеросклеротичного ураження артерій нижніх кінцівок TASC 2. Оцінювання показників НЛС виконали на момент госпіталізації хворого у стаціонар, до проведення хірургічного або консервативного лікування. Результати. Середня кількість НЛС у групах: TASC A – 2,76 ± 0,72, TASC B – 4,00 ± 1,20, TASC C – 4,50 ± 2,38, TASC D – 5,15 ± 2,09. Рівень НЛС значуще підвищувався зі збільшенням класу TASC 2. Показники НЛС були значно вищі в пацієнтів з «агресивнішим» і багаторівневим типом ураження артерій нижніх кінцівок, а саме TASC C і D. У пацієнтів з ураженням артерій нижніх кінцівок типу D рівень НЛС виявився на 46,4 % вищим, ніж у хворих з ураженням типу А за TASC 2. Висновки. Рівень нейтрофіл-лімфоцитарного співвідношення на 29,8 % (p 0,05) вищий у пацієнтів із C і D типами атеросклеротичного ураження за класифікацією TASC 2, ніж у хворих з ураженнями типу А та В. Рівень нейтрофіл-лім-фоцитарного співвідношення понад 3,05 можна розцінювати як маркер більш дифузного атеросклеротичного ураження артерій нижніх кінцівок, враховуючи рівні чутливості та специфічності (70,7 %, 75,8 %, p 0,001).

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
19.


   
    Гематоспермія: норма чи патологія? Сучасні підходи до етіопатогенезу, діагностики та лікування [Текст] / О. А. Нікіфоров [та ін.] // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 437-442 . - ISSN 2306-4145
MeSH-головна:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ БОЛЕЗНИ (диагностика, лекарственная терапия, ультрасонография, этиология)
СПЕРМОГРАММА (использование, методы)
МОЧА (микробиология, химия)
КРОВИ ХИМИЧЕСКИЙ АНАЛИЗ (использование)
Анотація: Здебільшого причина появи крові у спермі залишається невідомою. За даними ВООЗ, приблизно 15 % чоловіків маютьтільки один епізод гематоспермії, який більше ніколи не повторюється. Для виявлення причини гематоспермії необхіднеклінічне обстеження в уролога-андролога та ретельний збір анамнезу. Основною метою обстеження є виявлення абовиключення андропатології, а також визначення тактики ведення пацієнтів із гематоспермією. Мета роботи – на підставі аналізу даних наукової літератури висвітлити актуальність проблеми гематоспермії в ре- продуктивній медицині, показати етіопатогенез, а також розглянути сучасні методи діагностики й лікування.Наявність крові у спермі може свідчити про серйозне захворювання, що є результатом андропатології. Точний відсотоквипадків виникнення гематоспермії невідомий, оскільки часто у процесі незахищеного статевого акту огляд еякулятунеможливий. Більша частина пацієнтів звертається на консультацію до фахівця відразу після першого епізоду гема-тоспермії. Основоположним моментом є клінічне обстеження та ретельний збір анамнезу.Основна мета обстеження пацієнтів із гематоспермією – визначення причини або специфічного стану, що потребуєлікування, а отже іррадіація симптоматики й патологічного стану. Для підтвердження факту гематоспермії, якщо ценеобхідно, використовується «контрацептивний тест», який полягає у зборі патологічного еякуляту у презерватив длядослідження. Надалі пацієнта оглядає уролог-андролог, з’ясовує дані анамнезу, призначає аналіз сім’яної рідини, за-гальний аналіз сечі та її культуральне дослідження, дослідження крові на фактори згортання, загальний аналіз крові,ультразвукове дослідження передміхурової залози за методом трансректального УЗД (ТРУЗД), треба виключити онкопа-тологію шляхом аналізу на простатоспецифічний антиген (ПСА), альфа-фетопротеїн (АФП), β-субодиницю хоріонічногогонадотропіну людини (ХГЛ) і лактатдегідрогенази (ЛДГ) крові. Головним у лікуванні пацієнтів із гематоспермією є впливна етіологічний фактор. У зв’язку зі збільшенням кількості відомостей фахової літератури й великим кроком впереду галузі променевої діагностики встановили багато причин гематоспермії. Методики лікування цього симптому такожрізні: консервативні та хірургічні, повністю залежать від етіологічного фактора. Якщо патологічний стан не виявили,лікар має взяти на себе роль психотерапевта для корекції сексуальної поведінки таких чоловіків. Висновки. Кров у спермі може свідчити про серйозне захворювання, що є результатом андропатології. Для виявлення причини гематоспермії необхідне клінічне обстеження в уролога-андролога та ретельний збір анамнезу. Основною метоюобстеження є виявлення, виключення патології; якщо така не визначена, потрібно переконати пацієнта в тому, що вінздоровий. Обов’язковими процедурами є аналіз сім’яної рідини, загальний аналіз сечі та її культуральне дослідження,дослідження крові на фактори згортання, загальний аналіз крові, ультразвукове дослідження передміхурової залозиза методом ТРУЗД, а також аналіз на ПСА, АФП, ХГЛ, ЛДГ крові для виключення злоякісної етіології гематоспермії.Сучасні методи дослідження дають змогу виявити причину виникнення гематоспермії в багатьох випадках, і більшістьпацієнтів потребують консервативного лікування етіологічного фактора, але також можуть бути застосовані хірургічніметоди корекції


Дод.точки доступу:
Нікіфоров, О. А.; Авраменко, Н. В.; Ломейко, О. О.; Михайлов, В. В.
Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
20.


    Сохань, А. В.
    Діагностичне та прогностичне значення рівнів гормонів гіпофізарно-надниркової системи в цереброспінальній рідині хворих на гострі нейроінфекції [Текст] / А. В. Сохань // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Т. 20, N 3. - С. 349-353 . - ISSN 2306-4145
MeSH-головна:
МЕНИНГИТ (диагностика, лекарственная терапия, этиология)
СПИННОМОЗГОВАЯ ЖИДКОСТЬ (действие лекарственных препаратов)
ГИДРОКОРТИЗОН (анализ)
АДРЕНОКОРТИКОТРОПНЫЙ ГОРМОН (анализ)
Анотація: Мета роботи – визначити діагностичне та прогностичне значення рівнів гормонів гіпофізарно-надниркової системи в цереброспінальній рідині пацієнтів із гострими нейроінфекціями різної етіології. Матеріали та методи. Здійснили комплексне обстеження 164 хворих на гострі нейроінфекції, які перебували на ліку- ванні в Харківській обласній клінічній інфекційній лікарні (Україна). Крім аналізу клінічного перебігу хвороби виконали дослідження ЦСР хворих для визначення рівнів АКТГ, альдостерону й кортизолу при надходженні у стаціонар і на 10–12 добу лікування. Результати. Результати показують підвищення рівнів АКТГ, альдостерону та кортизолу залежно від тяжкості стану хворого та від етіології захворювання. У пацієнтів із тяжким перебігом нейроінфекції на 1 день лікування показники всіх визначених гормонів були вірогідно вищі, ніж у хворих середньої тяжкості як при вірусних, так і при бактеріаль- них нейроінфекціях (р 0,001). Виявили також сильну зворотну кореляцію між рівнем альдостерону та ступенем порушення свідомості за шкалою ГЛАЗГО (r

Примірників всього: 4
ЧЗ (2), ФБ2 (1), СБО (1)
Свободны: ЧЗ (2), ФБ2 (1), СБО (1)
Знайти схожі
 1-20    21-30 
 
Стандартний
Розширений
Професійний
За словником
ДРНТІ-навігатор
УДК-навігатор
Тематичний навігатор
Статистика
за 10.07.2024
Кількість запитів 565
Кількість відвідувачів 1
© Международная Ассоциация пользователей и разработчиков электронных библиотек и новых информационных технологий
(Ассоциация ЭБНИТ)