Part 1. Interplay Between Tumor Cells, Stroma and Inflammatory Infiltrate in Regulating Tumor Micro-Environment -- Tumor Immuno-Environment in Cancer Progression and Therapy -- Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment -- Regulation of CTL Infiltration Within the Tumor Microenvironment -- The Role of Tumor Microenvironment in Cancer Immunotherapy -- Part 2. Mediators of Tumor Microenvironment -- Immunogenic and Non-Immunogenic Cell Death in the Tumor Microenvironment -- Exosomes in Cancer: Another Mechanism of Tumor-Induced Immune Suppression -- Chemo-immunotherapy: Impact of Indoleamine 2,3-dioxygenase in Defining Immunogenic versus Tolerogenic Cell Death in the Tumor Microenvironment -- Targeting Myeloid-Derived Suppressor Cells in Cancer -- Tryptophan catabolism and cancer immunotherapy targeting IDO mediated immune Suppression -- Part 3. Emerging Targets and Technologies of Modulation of Tumor Microenvironment -- Tumor Microenvironment in Cancer Progression and Therapy -- The Role of the Immune System and Immunoregulatory Mechanisms Relevant to Melanoma -- Oncolytic Virotherapy and the Tumor Microenvironment -- The Impact of Housing Temperature Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous Role for the Nervous System -- (Immuno)therapeutic Targeting of Tumor-Associated Blood Vessels -- Adaptive Resistance to Cancer Immunotherapy -- Imaging the Tumor Microenvironment.

Establishing New Cut-Off Limits for Galactose 1-Phosphate-Uridyltransferase Deficiency for the Dutch Newborn Screening Programme -- Four Years of Diagnostic Challenges with Tetrahydrobiopterin Deficiencies in Iranian Patients -- Endurance Exercise Training in Young Adults with Barth Syndrome: A Pilot Study -- Hydroxysteroid 17-Beta Dehydrogenase Type 10 Disease in Siblings -- Reliable Diagnosis of Carnitine Palmitoyltransferase Type IA Deficiency by Analysis of Plasma Acylcarnitine Profiles -- Relationships Between Childhood Experiences and Adulthood Outcomes in Women with PKU: A Qualitative Analysis -- The Effect of S-Adenosylmethionine on Self-Mutilation in a Patient with Lesch–Nyhan Disease -- Low Protein Formula: Consequences of Quantitative Effects of Pre-analytical Factors on Amino Acid Concentrations in Plasma of Healthy Infants -- A Multiplatform Metabolomics Approach to Characterize Plasma Levels of Phenylalanine and Tyrosine in Phenylketonuria -- Japanese Male Siblings with 2-Methyl-3-Hydroxybutyryl-CoA Dehydrogenase Deficiency (HSD10 Disease) Without Neurological Regression -- Newborn Screening for Vitamin B6 Non-responsive Classical Homocystinuria: Systematical Evaluation of a Two-Tier Strategy -- Management of an LCHADD Patient During Pregnancy and High Intensity Exercise -- Rare Case of Hepatic Gaucheroma in a Child on Enzyme Replacement Therapy -- Newborn Screening Programmes in Europe, Arguments and Efforts Regarding Harmonisation: Focus on Organic Acidurias -- Whole Exome Sequencing Identifies the Genetic Basis of Late-Onset Leigh Syndrome in a Patient with MRI but Little Biochemical Evidence of a Mitochondrial Disorder.

1. Non-coding RNAs in the vasculature -- Introduction (Thomas Thum, Stefanie Dimmeler) -- Non-coding RNAs in vascular Development and Angiogenesis (Nathan Lawson or  Didier Steinier) -- 2. Diagnostics of Vascular Diseases using circulating miRNAs -- 2.1 Basic and Technical Principles (Manuel Mayr) -- 2.2 Diagnostics use of circulating miRNAs in cardiovascular diseases (Andreas Zeiher , Stephan Fichtlscherer) -- 2.3 Non-coding RNAs in Ischemic cardiovascular disease and repair mechanisms (incl. AMI,  cell therapy) (Ulf Landmesser) -- 3. Non-coding RNas in Diabetes and Metabolic Diseases -- 3.1 Non-coding RNAs in vascular complications of Diabetes (Costanza Emanueli) -- 3.2 Non-coding RNAs in Metabolic Diseases, Cholesterol Metabolism (Carlos Fernandez-Hernando) -- 3.3 Non-coding RNAs in Atherosclerosis and Vascular Inflammation (incl. aging processes and aneurysms, platelelets)(Christian Weber, Feinberg) -- 4. Outlook and Perspectives (long non coding RNAs, microvesicles, new therapies, ect) (Thomas Thum, Stefanie Dimmeler).

1. Breast Carcinogenesis -- 2. Non-melanoma skin cancer, Actinic keratosis and squamous cell cancer -- 3. Molecular Pathogenesis of Soft Tissue Tumours -- 4. Colorectal carcinogenesis -- 5. Pancreatic Carcinogenesis -- 6. Hepatocellular carcinogenesis -- 7. Neuroendocrine tumorigenesis -- 8. Molecular etiopathogenesis of extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue -- 9. Urologic neoplasms including Kidney and Urinary Bladder -- 10. Molecular Carcinogenesis of Urinary Bladder Cancer -- 11. Gynecologic Carcinogenesis -- 12. CTCs and ctDNA -- 13. Computational Pathology -- 14. In vitro three-dimensional cultures as tool for personalized medicine -- 15. Stratifying cancer therapies by molecular interactions and imaging -- 16. Molecular Modelling.

Preliminary Table of Contents Topic 1. Plant-based medicine in health care -- Chapter 1.1. An overview of plant derived antioxidants -- Chapter 1.2. Health benefits of fruits and vegetables -- Chapter 1.3. Antioxidant potential of African medicinal plants -- Chapter 1.4. Antioxidant potential of South America medicinal plants -- Chapter 1.5. Plants of Indian traditional medicine with antioxidant activity -- Chapter 1.6. Nutritional antioxidants and their sites of action.- Topic 2. Nutritional antioxidants in reproductive health and development -- Chapter 2.1. Antioxidant therapy in reproductive health -- Chapter 2.2. Antioxidant therapy in assisted reproductive technologies -- Chapter 2.3. Antioxidant therapy in prenatal developmental disorders -- Chapter 2.4. Antioxidant therapies: a potential role in perinatal medicine -- Topic 3. Nutritional antioxidants in health maintenance -- Chapter 3.1. Significance of dietary antioxidants for health -- Chapter 3.2. Functional antioxidant foods and nutraceuticals.- Chapter 3.3. Antioxidants and polyunsaturated fatty acids in health maintenance -- Chapter 3.4. Impact of dietary antioxidants on sport performance -- Topic 4. Nutritional antioxidants in health and disease -- Chapter 4.1. Antioxidants in the prevention and treatment of diseases -- Chapter 4.2. Antioxidant therapy in endocrine disorders -- Chapter 4.3. Antioxidants in the prevention and treatment of obesity -- Chapter 4.4. Antioxidant nutritional strategies for successful aging Topic 5. Nutritional antioxidant intervention against environmental pollution -- Chapter 5.1. Antioxidant therapy against environmentally induced oxidative stress -- Chapter 5.2. Antioxidant therapy against environmental pollutants and associated diseases.- Chapter 5.3. Protective role of dietary antioxidants against chemical-induced oxidative stress -- Chapter 5.4. Preventive and therapeutic roles of dietary antioxidants against air pollutant exposure.  .

Part 1: Overview of Organelle Contacts -- Chapter 1: Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research -- Part 2: Organization and Roles of Organelle Contact Sites -- Chapter 2: Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs) -- Chapter 3: Regulation of mitochondrial dynamics and autophagy by the mitochondria-associated membrane -- Chapter 4: Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ signaling: the importance of mitochondria associated membranes (MAMs) -- Chapter 5: Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites -- Chapter 6: Endoplasmic Reticulum - Plasma Membrane cross-talk mediated by the extended synaptotagmins -- Chapter 7: Endoplasmic Reticulum–Plasma membrane contacts regulate cellular excitability -- Chapter 8: The lipid droplet and the endoplasmic reticulum -- Chapter 9: Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis -- Chapter 10: Discovery and roles of ER-endolysosomal contact sites in disease -- Part 3: Infection and Disease -- Chapter 11: Alzheimer disease -- Chapter 12: Mitochondrial-associated membranes in Parkinson’s disease -- Chapter 13: Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes -- Chapter 14: Mitochondria–endoplasmic reticulum contact sites mediate innate immune responses -- Chapter 15: Hepatitis C Virus Replication -- Chapter 16: Hijacking of Membrane Contact Sites by Intracellular Bacterial Pathogens -- Chapter 17: Alterations in Ca2+ signalling via ER-mitochondria contact site remodelling in cancer.

Foreword -- Part 1. Physiology -- Part 2. Methodology -- Part 3. Pathology: Hemostatic disorders -- Part 4. Pathology: Thrombotic disorders -- Part 5. Pathology: Non hemostatic or thrombotic disorders -- Part 6. Pharmacology -- Part 7. Therapy.

Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.

Chromaffin cells and Granins: History and Perspectives -- The extended granin family: structure, function, and biomedical implications -- CgA and CgB in granule secretion -- Proteolytic processing of CgA and CgB/Antimicrobial properties of Chromogranins -- Chromogranins and inositol 1,4,5-trisphosphate-dependent Ca2+-signaling -- CgA in angiogenesis and tumor biology -- Full lenght CgA: a multifaceted protein in cardiovascular health and disease -- Physio-pharmacological aspects of three Chromogranin A-derived peptides: Vasostatin, Catestatin, and Serpinin -- Comparative aspects of CgA-derived peptides in cardiac homeostasis -- Molecular and cellular mechanisms of action of CgA-derived peptides in cardiomyocytes and endothelial cells -- CgA-derived peptides in pre- and post-conditioning cardioprotection -- Catestatin in physiopathology -- Serpinin: from biosynthesis to cell biology and physiopathology -- Pancreastatin and metabolism -- Chromogranins and the quantum release of catecholamines.

Part A Model Systems of Kidney Development and Disease -- 1 Drosophila Malpighian tubule: A model for understanding kidney development, function and disease -- 2 Zebrafish pronephros development -- 3 Zebrafish as a model of kidney disease -- 4 Use of Xenopus frogs to study renal development/repair -- Part B Cell Renewal, Differentiation and Fate in Nephrogenesis -- 5 Tissue-specific p53 functions during kidney development -- 6 Growth factor regulation in the nephrogenic zone of the developing kidney -- 7 Development and diseases of the collecting ductsystem -- 8 Origin and function of the renal stroma in health and disease -- Part C Nephron Morphogenesis and Maintenance -- 9 Imaging, analysing and interpreting branching morphogenesis in the developing kidney -- 10 Genetic syndromes affecting kidney development -- 11 Primary cilia in cystic kidney disease -- 12 Inflammation and fibrosis in polycystic kidney disease -- 13 Epithelial to mesenchymal transition (EMT) andendothelial to mesenchymal transition (EndMT): Role and implications in kidney fibrosis.

1. The extracellular matrix of tumors: a focus on fibronectin and fibulin-5 -- 2. Internalization of collagen: an important matrix turnover pathway in cancer -- 3. Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression -- 4. Versican: Role in Cancer Tumorigenesis -- 5. Engineering advanced models of the glioblastoma microenvironment using biomaterials -- 6. Breaching and opening basement membrane barriers: the anchor cell leads the way.

Overview: gene transfer strategies, principles, applications -- Manufacturing viral gene therapy vectors: general approaches and challenges -- Retrovirus- and lentivirus-based vectors -- Preclinical and clinical applications of retroviral vectors -- Preclinical and clinical applications of lentiviral vectors -- Retrovirus and lentivirus integration -- Adenovirus-based vectors for gene therapy -- Adenoviral vector-host interactions -- Helper-dependent adenoviral vectors -- Gene therapy for cancer treatment -- Oncolytic adenoviruses for cancer treatment -- Vaccination by gene transfer vectors -- AAV vectors: general features and applications -- Adaptive immune response to viral vector delivery -- Herpes viruses: general features and applications -- RNA interference-based strategy for treatment of human diseases -- Antisense oligonucleotide based therapeutics -- Gene editing strategies -- Nonviral vectors.

Nanomaterials in medicine -- Magnetic properties (diamagnetism, paramagnetism, ferromagnetism, ferrimagnetism, antiferromagnetism, superparamagnetism) -- Imaging probes -- Magnetic resonance imaging (MRI) -- Bases of MRI -- MRI contrast agents -- Paramagnetic gadolinium complexes -- Superparamagnetic iron oxide nanoparticles -- Synthesis of magnetic nanoparticles -- Stabilization of magnetic nanoparticles -- Physico-chemical characterization of nanoparticles -- MRI applications -- Conclusions.

Difficulties in Daily Life and Associated Factors, and QoL of Children with Inherited Metabolic Disease and Their Parents in Japan: A Literature Review -- Swallow Prognosis and Follow-Up Protocol in Infantile Onset Pompe Disease -- Clinical and Genetic Characteristics of Romanian Patients with Mucopolysaccharidosis Type II -- Gastrointestinal Health in Classic Galactosemia -- Management of Life-Threatening Tracheal Stenosis and Tracheomalacia in Patients with Mucopolysaccharidoses -- Brain White Matter Integrity Mediates the Relationship Between Phenylalanine Control and Executive Abilities in Children with Phenylketonuria -- The Challenges of a Successful Pregnancy in a Patient with Adult Refsum’s Disease due to Phytanoyl-CoA Hydroxylase Deficiency -- Novel Homozygous Missense Mutation in SPG20 Gene Results in Troyer Syndrome Associated with Mitochondrial Cytochrome c Oxidase Deficiency -- Lethal Neonatal LTBL Associated with Biallelic EARS2 Variants: Case Report and Review of the Reported Neuroradiological Features -- Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling -- Peak Jump Power Reflects the Degree of Ambulatory Ability in Patients with Mitochondrial and Other Rare Diseases -- RARS2 Mutations: Is Pontocerebellar Hypoplasia Type 6 a Mitochondrial Encephalopathy? -- Missed Newborn Screening Case of Carnitine Palmitoyltransferase-II Deficiency -- Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD) -- Erratum to: Missed Newborn Screening Case of Carnitine Palmitoyltransferase-II Deficiency -- Erratum to: Leigh-Like Syndrome Due to Homoplasmic m.8993T>G Variant with Hypocitrullinemia and Unusual Biochemical Features Suggestive of Multiple Carboxylase Deficiency (MCD).

Part I Diagnosis -- 1 Classification of adenocarcinoma of the lung - with a special reference to prognosis -- 2 Screening lung cancer with low dose CT combined with molecular markers -- 3 PET-CT, bio-imaging for predicting prognosis and response to chemotherapy in patients with lung cancer -- 4 Methods in molecular diagnosis -- 5 Accurate nodal staging and biomarker testing with endobronchial ultrasound-guided transbronchial needle aspiration -- 6 Next generation sequencing and bioinformatics -- 7 Companion Diagnostics -- Part II Treatment -- 8 Small cell lung cancer and molecular targeted therapy -- 9 Locally advanced non-small cell lung cancer and molecular targeted therapy -- 10 EGFR mutant -- 11 ALK mutant -- 12 Minor-driver mutant -- 13 Mechanism of resistance to targeted molecular therapy -- 14 Immunotherapy -- 15 Lung cancer complicated with interstitial lung diseases -- 16 Management of adverse effects by molecular targeted therapy and immunotherapy -- Part III Evaluation -- 17 Health related-quality of life in molecular targeted therapy -- 18 Gene signature -- Part IV Novel approach -- 19 Targeting epithelial-mesenchymal transition and cancer stem cell- 20 Targeting the Lung Cancer Microenvironment: Harnessing Host Responses.

Development of the lung -- Anatomy and Histology of normal lung -- Pediatric Pulmonary Pathology -- Edema -- Air filling diseases -- Airway diseases -- Smoking related lung diseases.

1. Identification of serum sirtuins as novel non-invasive protein markers for frailty -- 2.Age-related morphological changes in the human pancreas -- 3.Changing population of neurons and glia in the human cochlear nucleus during aging -- 4.Age-related changes in the expression level of insulin-like growth factor-1 and its related signaling pathway in mice -- 5.Differential expression of arginase I and its regulation by dexamethasone in the liver of mice as a function of age -- 6.Molecular and cellular basis of memory enhancing effects ofBacopa monnieri extract on diabetes mellitus induced memory impairment in mice -- 7.Brain aging and oxidative pathology -- 8.Antiepileptic potential of dehydroepiendrosterone (DHEA) -- 9.Curcumin attenuates memory impairment by modulating the expression of CamKIIα during aging -- 10.Dietary restriction, an intervention for healthy aging -- 11.Study of anti-ageing property of moringaoleifera leaves in fish brain -- 12.Alterations in the structure and function of the chromatin during aging -- 13.Postnatal exposure of PBDE-209 impairs spatial memory in young mice:Relation of glutamate and oxidant-antioxidant homeostasis in the frontal cortex and hippocampus -- 14.Differential expression of long intergenic noncoding RNA (lincRNA) in the rat brain during aging -- 15.Dietary restriction up-regulates expression and activity of cardiac and skeletal muscle inorganic pyrophosphatase in mice as a function of age -- 16.Age-related changes in rat kidney antioxidant enzymes and oxidative stress parameters with special reference to catalase promoter methylation pattern -- 17.Recovery of age-related memory loss: hopes and challenges -- 18.Electrophysiological ageing of the brain : Ageing-related impairments in neuronal and cognitive functions -- 19.Role of autophagy in life-extension using Dictyostelium discoideum as a model system -- 20.SIRT-1: An emerging target for age-related neurodegenerative diseases -- 21.Neuroinflammation and the aging brain -- 22.Expression and regulation of Pax6 in brain of aging mice -- 23.Basic tenets of Ayurvedic Gerontology -- 24.Potential use of Ashwagandha (Withania somnifera) for alleviation of old age-associated problems.

Cerebrotendinous Xanthomatosis Presenting with Infantile Spasms and Intellectual Disability -- Hyperammonemia as a Presenting Feature in Two Siblings with FBXL4 Variants -- Intracranial Hypertension in Cystinosis Is a Challenge: Experience in a Children’s Hospital -- Severe Respiratory Acidosis in Status Epilepticus as a Possible Etiology of Sudden Death in Lesch–Nyhan Disease: A Case Report and Review of the Literature -- Vitamin B12 Administration by Subcutaneous Catheter Device in a Cobalamin A (cblA) Patient -- Expansion of the Phenotypic Spectrum of Propionic Acidemia with Isolated Elevated Propionylcarnitine -- Previously Unreported Biallelic Mutation in DNAJC19:Are Sensorineural Hearing Loss and Basal Ganglia Lesions Additional Features of Dilated Cardiomyopathy and Ataxia (DCMA) Syndrome? -- Lysosomal Storage Disorders in Nonimmune Hydrops Fetalis (NIHF): An Indian Experience -- The Risk of Fatty Acid Oxidation Disorders and Organic Acidemias in Children with Normal Newborn Screening -- Clinical and Mutational Characterizations of Ten Indian Patients with Beta-Ketothiolase Deficiency -- Atypical Presentation and Treatment Response in a Child with Familial Hypercholesterolemia Having a Novel LDLR Mutation -- Development of a Tandem Mass Spectrometry Method for Rapid Measurement of Medium- and Very-Long-Chain Acyl-CoA Dehydrogenase Activity in Fibroblasts -- Analysis of Melanin-like Pigment Synthesized from Homogentisic Acid, with or without Tyrosine, and Its Implications in Alkaptonuria -- Bone Health in Classic Galactosemia: Systematic Review and Meta-Analysis -- Cognitive Development in a Young Child with Mucolipidosis Type IV: A Case Report -- White Matter Microstructure and Subcortical Gray Matter Structure Volumes in Aspartylglucosaminuria; a 5-Year Follow-up Brain MRI Study of an Adolescent with Aspartylglucosaminuria and His Healthy Twin Brother -- Erratum to: White Matter Microstructure and Subcortical Gray Matter Structure Volumes in Aspartylglucosaminuria; a 5-Year Follow-up Brain MRI Study of an Adolescent with Aspartylglucosaminuria and His Healthy Twin Brother.

35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters -- Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria -- Discovery and Development of Novel Drugs -- Computer Aided Drug Discovery from Marine Compounds: Identification of the Three-dimensional Structural Features Responsible for Antimalarial Activity -- BlueGenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification -- New Target Sites for Treatment of Osteoporosis -- Biocalcite and Carbonic Acid Activators -- Electrospinning of Bioactive Wound Healing Nets -- Entotheonella Bacteria as Source of Sponge-derived Natural Products: Opportunities for Biotechnological Production.