Bone Toxicology [Electronic resource] / ed.: Smith, Susan Y., Varela, Aurore., Samadfam, Rana. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 474 p. 72 illus., 63 illus. in color. - ISBN 9783319561929 Зміст:  Рубрики: Pharmacology. Pharmaceutical technology. Animal models in research. Pharmacology/Toxicology. Pharmaceutical Sciences/Technology. Animal Models. Анотація: The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Smith, Susan Y. \ed.\; Varela, Aurore. \ed.\; Samadfam, Rana. \ed.\ Вільних прим. немає |
The Cricket as a Model Organism [Electronic resource] : development, Regeneration, and Behavior / / ed. Horch, Hadley Wilson. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 376 p. 106 illus., 62 illus. in color. - ISBN 9784431564782 Зміст: Рубрики: Animal models in research. Behavioral sciences. Developmental biology. Food—Biotechnology. Animal Models. Behavioral Sciences. Developmental Biology. Food Science. Анотація: This book covers a broad range of topics about the cricket from its development, regeneration, physiology, nervous system, and behavior with remarkable recent updates by adapting the new, sophisticated molecular techniques including RNAi and other genome editing methods. It also provides detailed protocols on an array of topics and for basic experiments on the cricket. While the cricket has been one of the best models for neuroethological studies over the past 60 years, it has now become the most important system for studying basal hemimetabolous insects. The studies of Gryllus and related species of cricket will yield insight into evolutionary features that are not evident in other insect model systems, which mainly focus on holometabolous insects such as Drosophila, Tribolium, and Bombyx. Research on crickets and grasshoppers will be important for the development of pest-control strategies, given that some of the most notorious pests also belong to the order Orthoptera. At the same time, crickets possess an enormously high “food conversion efficiency”, making them a potentially important food source for an ever-expanding human population. This volume provides a comprehensive source of information as well as potential new applications in pest management and food production of the cricket. It will inspire scientists in various disciplines to use the cricket model system to investigate interesting and innovative questions. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Horch, Hadley Wilson. \ed.\; Mito, Taro. \ed.\; Popadić, Aleksandar. \ed.\; Ohuchi, Hideyo. \ed.\; Noji, Sumihare. \ed.\ Вільних прим. немає |
Reznikova, Zhanna. Studying Animal Languages Without Translation: An Insight from Ants [Electronic resource] / Zhanna. Reznikova ; . - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 92 p. 25 illus., 15 illus. in color. - ISBN 9783319449180 Зміст: Рубрики: Animal physiology. Animal models in research. Coding theory. Information theory. Invertebrates. Neurobiology. Animal Physiology. Animal Models. Coding and Information Theory. Invertebrates. Neurobiology. Анотація: The Author of this new volume on ant communication demonstrates that information theory is a valuable tool for studying the natural communication of animals. To do so, she pursues a fundamentally new approach to studying animal communication and “linguistic” capacities on the basis of measuring the rate of information transmission and the complexity of transmitted messages. Animals’ communication systems and cognitive abilities have long-since been a topic of particular interest to biologists, psychologists, linguists, and many others, including researchers in the fields of robotics and artificial intelligence. The main difficulties in the analysis of animal language have to date been predominantly methodological in nature. Addressing this perennial problem, the elaborated experimental paradigm presented here has been applied to ants, and can be extended to other social species of animals that have the need to memorize and relay complex “messages”. Accordingly, the method opens exciting new dimensions in the study of natural communications in the wild. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Reznikova, Zhanna. \.\ Вільних прим. немає |
Banerjee, Ena Ray. Perspectives in Translational Research in Life Sciences and Biomedicine [Electronic resource] : translational Outcomes Research in Life Sciences and Translational Medicine, Volume 2 / / Ena Ray. Banerjee ; . - 1st ed. 2017. - [S. l. : s. n.]. - XII, 132 p. 32 illus., 22 illus. in color. - ISBN 9789811058707 Зміст: Рубрики: Regenerative medicine. Tissue engineering. Molecular biology. Gene therapy. Animal models in research. Medical biochemistry. Regenerative Medicine/Tissue Engineering. Molecular Medicine. Gene Therapy. Animal Models. Medical Biochemistry. Анотація: This book is a collation of translational research outcomes in the area of life research, which was formerly used mainly for academic pursuits. The studies described focus on innovative interdisciplinary approaches to unraveling problems in life sciences and biomedicine using biodiversity exploration and green technology. The techniques and models presented offer a ready reckoner for researchers in academic institutions and industry, and also provide valuable insights into fundamental research. The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how combination cultures of commensalistic bacteria can help boost immunity; development of functional food from natural products from plant, animal, and microbial sources in the nutraceuticals domain; as well as synthesis and mechanisms in nanomedicine and nanoscaffolds in biomedicine. The studies and discourses described touch upon topics that explore biodiversity for the development of disease models, toxicity studies, developmental studies, and harvesting of bioactive compounds for alternative income generation and poverty alleviation, and as a result, bring about economic and ecologic sustainability. This multidimensional and multidisciplinary book focuses on tissue-specific targeting by nanodrugs, development of bioengineering formats for cell- based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and syndromes. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Banerjee, Ena Ray. \.\ Вільних прим. немає |
Alternatives for Dermal Toxicity Testing [Electronic resource] / ed.: Eskes, Chantra., van Vliet, Erwin., Maibach, Howard I. - 1st ed. 2017. - [S. l. : s. n.]. - XX, 592 p. 92 illus., 61 illus. in color. - ISBN 9783319503530 Зміст: Рубрики: Dermatology. Pharmacology. Animal models in research. Dermatology. Pharmacology/Toxicology. Animal Models. Анотація: This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Eskes, Chantra. \ed.\; van Vliet, Erwin. \ed.\; Maibach, Howard I. \ed.\ Вільних прим. немає |
Liang, Xin. Mechanosensory Transduction in Drosophila Melanogaster [Electronic resource] / Xin. Liang, Sun, Landi., Liu, Zhen. ; . - 1st ed. 2017. - [S. l. : s. n.]. - IX, 82 p. 30 illus., 26 illus. in color. - ISBN 9789811065262 Зміст: Рубрики: Neurochemistry. Biochemistry. Animal models in research. Neurochemistry. Biochemistry, general. Animal Models. Анотація: This book offers an essential introduction for all graduate students and researchers who are working on or interested in mechanotransduction using fruit flies as their model organisms. Designed for accessibility, it follows a simple five-chapter structure, beginning with a general introduction to mechanotransduction in physiology (Chapter 1) and some basic considerations on the principles behind mechanotransduction processes (Chapter 2). In turn, Chapters 3, 4 and 5 focus on mechanoreceptors in Drosophila melanogaster. Chapter 3 explains how the fly’s mechanosensitive cells (i.e. mechanoreceptors) contribute to its daily life, while Chapter 4 explores the ultrastructural and mechanical basis for the working mechanisms of various fly mechanoreceptors. Lastly, Chapter 5 elaborates on the structure, function and physiology of mechanosensitive molecules in fly mechanoreceptors. Accordingly, the book provides an overall framework, helping readers understand mechanosensory transduction, from the physiological level to the molecular level. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Sun, Landi.; Liu, Zhen.; Liang, Xin. \.\ Вільних прим. немає |
Animal Models of Neurological Disorders [Electronic resource] : principle and Working Procedure for Animal Models of Neurological Disorders / / ed.: Bansal, Puneet Kumar., Deshmukh, Rahul. - 1st ed. 2017. - [S. l. : s. n.]. - XVIII, 343 p. 68 illus., 45 illus. in color. - ISBN 9789811059810 Зміст: Рубрики: Neurosciences. Animal models in research. Neurobiology. Pharmacology. Neurosciences. Animal Models. Neurobiology. Pharmacology/Toxicology. Анотація: This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Bansal, Puneet Kumar. \ed.\; Deshmukh, Rahul. \ed.\ Вільних прим. немає |
Comparative Medicine [Electronic resource] : disorders Linking Humans with Their Animals / / ed. Jensen-Jarolim, Erika. - 1st ed. 2017. - [S. l. : s. n.]. - XIX, 230 p. 24 illus., 22 illus. in color. - ISBN 9783319470078 Зміст: Рубрики: Animal models in research. Animal physiology. Human physiology. Internal medicine. Veterinary medicine. Animal Models. Animal Physiology. Human Physiology. Internal Medicine. Veterinary Medicine/Veterinary Science. Анотація: This book highlights the most significant diseases for humans and their dogs, cats and horses. The examples discussed, which include allergies, osteoporosis, cancer and many more, illustrate that humans and their companion animals may in fact develop similar diseases. The reader - whether expert or interested lay - can thus directly compare between human and animal patients. The animal patient thereby represents a natural disease model, which besides the experimental models, is urgently needed to improve the therapeutic options for both humans and animals. Есть полнотекстовые версии (для доступа требуется авторизация) Дод.точки доступу: Jensen-Jarolim, Erika. \ed.\ Вільних прим. немає |