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1.


   
    Protein Reviews [Electronic resource] : volume 19 / / ed. Atassi, M. Zouhair. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 256 p. 30 illus., 28 illus. in color. - ISBN 9789811076114
    Зміст:
Рубрики: Proteins .
   Protein Structure.
Анотація: The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. Volume 19 focusses on Purinergic receptors, also termed purinoceptors. These are plasma membrane proteins present in nearly all mammalian tissues. They participate in a number of cell functions that include proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion and have been associated with learning and memory, feeding conduct, movement and sleep. They facilitate relaxation of smooth muscle of the gut in response to adenosine (P1 receptors) or ATP (P2 receptors). The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected receptor proteins. The first chapter in this volume reviews the current research on the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1. This is followed by a chapter dealing with Structure and function of the two-component cytotoxins of Staphylococcus aureus and a chapter on Membrane Fusion and Infection involving the Influenza virus Hemagglutinin. The fourth chapter reviews the impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel. Then there is a chapter that discusses some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation. The next chapter deals with regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes. This is followed by a chapter on coding of Class I and II aminoacyl-tRNA synthetases; a chapter on regulation of nephrin phosphorylation in diabetes and chronic kidney injury and a chapter on The Structure-Forming Juncture in oxidative protein folding and the events in the ER. Finally the last chapter deals with the polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.  .
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Atassi, M. Zouhair. \ed.\
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2.


   
    Protein Reviews [Electronic resource] : volume 17 / / ed. Atassi, M. Zouhair. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 163 p. 50 illus., 45 illus. in color. - ISBN 9789811037108
Рубрики: Proteins .
   Protein Structure.
Анотація: The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. Volume 17 of Protein Reviews is the beginning of a new publication format. The volumes will appear online before they are published in a printed book. Articles will be selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in this volume are authored by experts in the field. They deal with aspects of structure and biological activity of selected proteins. Specific chapters deal with the aggregation of FET proteins (FUS, EWSR1, TAF15) as a pathological change in amyotrophic lateral sclerosis, structural changes fundamental to gating of the cystic fibrosis transmembrane conductance regulator anion channel pore, the dual roles for epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) in cancer progression, controlling autolysis during flagella insertion in Gram-negative bacteria, the regulation of skeletal muscle myoblast differentiation and the proliferation by pannexins, hyaluronidase and chondroitinase, factors that control mitotic spindle elongation, how secreted phospholipase A2 type IIA (sPLA2-IIA) activates integrins in an allosteric manner, the simple and unique allosteric machinery of Thermus caldophilus lactate dehydrogenase, and the reduction of chemically stable multibonds: Nitrogenase-like biosynthesis of tetrapyrroles. This volume is intended for research scientists, clinicians, physicians, and graduate students in fields of biochemistry, cell biology, molecular biology microbiology, immunology and genetics. .
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3.


   
    Network Biology [Electronic resource] / ed. Nookaew, Intawat. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 202 p. - ISBN 9783319564609
    Зміст:
Рубрики: Biotechnology.
   Proteins .
   Medicinal chemistry.
   Bioinformatics.
   Biotechnology.
   Protein Structure.
   Medicinal Chemistry.
   Bioinformatics.
Анотація: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
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4.


   
    Protein Reviews [Electronic resource] : volume 18 / / ed. Atassi, M. Zouhair. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 203 p. 50 illus., 46 illus. in color. - ISBN 9789811069222
    Зміст:
Рубрики: Proteins .
   Protein Structure.
Анотація: The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in volume 18 are authored by experts in the field. They deal with aspects of structure and/or biological activity of selected proteins. The chapters review current research of the following topics: the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1, Structure and function of the two-component cytotoxins of Staphylococcus aureus, Membrane Fusion and Infection involving the influenza virus hemagglutinin, The impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel, Discussion of some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation, Regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes, Coding of Class I and II aminoacyl-tRNA synthetases, Nephrin phosphorylation in diabetes and chronic kidney injury, The structure-forming juncture in oxidative protein folding and the events in the ER, The polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.
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Atassi, M. Zouhair. \ed.\
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5.


   
    Biological Small Angle Scattering: Techniques, Strategies and Tips [Electronic resource] / ed. Chaudhuri, Barnali. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - X, 268 p. 87 illus., 77 illus. in color. - ISBN 9789811060380
    Зміст:
Рубрики: Proteins .
   Molecular biology.
   Biotechnology.
   Protein Structure.
   Molecular Medicine.
   Biotechnology.
Анотація: This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behave in solution. SAS provides distinct and complementary data for integrative structural biology approaches in combination with other widely used probes, such as X-ray crystallography, Nuclear magnetic resonance, Mass spectrometry and Cryo-electron Microscopy. The development of brilliant synchrotron small-angle X-ray scattering (SAXS) beam lines has increased the number of researchers interested in solution scattering. SAS is especially useful for studying conformational changes in proteins, highly flexible proteins, and intrinsically disordered proteins. Small-angle neutron scattering (SANS) with neutron contrast variation is ideally suited for studying multi-component assemblies as well as membrane proteins that are stabilized in surfactant micelles or vesicles. SAS is also used for studying dynamic processes of protein fibrillation in amyloid diseases, and pharmaceutical drug delivery. The combination with size-exclusion chromatography further increases the range of SAS applications. The book is written by leading experts in solution SAS methodologies. The principles and theoretical background of various SAS techniques are included, along with practical aspects that range from sample preparation to data presentation for publication. Topics covered include techniques for improving data quality and analysis, as well as different scientific applications of SAS. With abundant illustrations and practical tips, we hope the clear explanations of the principles and the reviews on the latest progresses will serve as a guide through all aspects of biological solution SAS. The scope of this book is particularly relevant for structural biology researchers who are new to SAS. Advanced users of the technique will find it helpful for exploring the diversity of solution SAS methods and applications. Chapter 3 of this book is available open access under a CC BY 4.0 license at link.springer.com.
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Chaudhuri, Barnali. \ed.\; Muñoz, Inés G. \ed.\; Qian, Shuo. \ed.\; Urban, Volker S. \ed.\
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6.


   
    TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease [Electronic resource] / ed.: Telerman, Adam., Amson, Robert. - 1st ed. 2017. - [S. l. : s. n.]. - X, 309 p. 51 illus., 36 illus. in color. - ISBN 9783319675916
    Зміст:
Рубрики: Cancer research.
   Proteins .
   Stem cells.
   Cell cycle.
   Apoptosis.
   Cancer Research.
   Protein Structure.
   Stem Cells.
   Cell Cycle Analysis.
   Apoptosis.
Анотація: This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book’s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.
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Telerman, Adam. \ed.\; Amson, Robert. \ed.\
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7.


   
    The Structural Basis of Arrestin Functions [Electronic resource] / ed. Gurevich, Vsevolod V. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 304 p. 53 illus., 51 illus. in color. - ISBN 9783319575537
    Зміст:
Рубрики: Biochemistry.
   Proteins .
   Animal Biochemistry.
   Protein Science.
   Protein Structure.
Анотація: This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death. Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery. The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings. The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes.
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Gurevich, Vsevolod V. \ed.\
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