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Загальна кількість знайдених документів : 12
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1.


   
    Phosphate Labeling and Sensing in Chemical Biology [Electronic resource] / ed. Jessen, Henning Jacob. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 239 p. 87 illus., 60 illus. in color. - ISBN 9783319603575
    Зміст:
Рубрики: Bioorganic chemistry.
   Proteins .
   Nucleic acids.
   Cell biology.
   Bioorganic Chemistry.
   Protein Science.
   Nucleic Acid Chemistry.
   Cell Biology.
Анотація: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
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2.


   
    Microwave Effects on DNA and Proteins [Electronic resource] / ed. Geddes, Chris D. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 298 p. 72 illus., 36 illus. in color. - ISBN 9783319502892
    Зміст:
Рубрики: Medicine.
   Proteins .
   Nucleic acids.
   Biophysics.
   Biological physics.
   Biomedicine, general.
   Protein Science.
   Nucleic Acid Chemistry.
   Biological and Medical Physics, Biophysics.
Анотація: For several years, researchers have been reporting the effects of microwave radiation/heating on both the structure and function of DNA, RNA and proteins. For the most part, favourable accelerated biological functions are observed as microwave induced heating occurs, but other not-so favourable effects are also observed, such as denaturation, fragmentation and the so called and ill-explained, non-thermal microwave effects. This volume, the first of its kind, brings researchers together from around the world to discuss their current findings and thinking on the effects of Microwaves on Biological systems, particularly DNA, RNA and proteins, in the form of contributed edited chapters.
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Geddes, Chris D. \ed.\
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3.


   
    Plant Biotechnology: Principles and Applications [Electronic resource] / ed. Abdin, Malik Zainul. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XVIII, 392 p. 44 illus., 33 illus. in color. - ISBN 9789811029615
    Зміст:
Рубрики: Plant breeding.
   Plant genetics.
   Plant physiology.
   Nucleic acids.
   Plant Breeding/Biotechnology.
   Plant Genetics and Genomics.
   Plant Physiology.
   Nucleic Acid Chemistry.
Анотація: The book traces the roots of plant biotechnology from the basic sciences to current applications in the biological and agricultural sciences, industry, and medicine. Providing intriguing opportunities to manipulate plant genetic and metabolic systems, plant biotechnology has now become an exciting area of research. The book vividly describes the processes and methods used to genetically engineer plants for agricultural, environmental and industrial purposes, while also discussing related bioethical and biosafety issues. It also highlights important factors that are often overlooked by methodologies used to develop plants’ tolerance against biotic and abiotic stresses and in the development of special foods, bio-chemicals, and pharmaceuticals. The topics discussed will be of considerable interest to both graduate and postgraduate students. Further, the book offers an ideal reference guide for teachers and researcher alike, bridging the gap between fundamental and advanced approaches.
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Abdin, Malik Zainul. \ed.\; Kiran, Usha. \ed.\; Kamaluddin. \ed.\; Ali, Athar. \ed.\
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4.


   
    RNA Metabolism and Gene Expression in Archaea [Electronic resource] / ed. Clouet-d'Orval, Béatrice. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 269 p. 49 illus., 37 illus. in color. - ISBN 9783319657950
    Зміст:
Рубрики: Nucleic acids.
   Microbiology.
   Proteins .
   Enzymology.
   Nucleic Acid Chemistry.
   Microbiology.
   Protein Science.
   Enzymology.
Анотація: This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. From synthesis to degradation and the implications of gene expression, it presents the current state of knowledge on archaeal RNA biology in 13 chapters. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system. While Archaea have long been considered exotic microbial extremophiles, they are now increasingly being recognized as important model microorganisms for the study of molecular mechanisms conserved across the three domains of life, and with regard to the relevance of similarities and differences to eukaryotes and bacteria. This unique book offers a valuable resource for all readers interested in the regulation of gene expression in Archaea and RNA metabolism in general.
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Clouet-d'Orval, Béatrice. \ed.\
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5.


   
    Genome Analysis and Human Health [Electronic resource] / ed.: Rawal, Leena., Ali, Sher. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 168 p. 19 illus. in color. - ISBN 9789811042980
    Зміст:
Рубрики: Human genetics.
   Molecular biology.
   Cancer research.
   Nucleic acids.
   Biomedical engineering.
   Human Genetics.
   Molecular Medicine.
   Cancer Research.
   Nucleic Acid Chemistry.
   Biomedical Engineering/Biotechnology.
Анотація: This book highlights selected current data and its relevance in the human health care system, offering a fundamental primer on genetics and human health. With the advent of new high-throughput technologies (for the whole genome including exome sequencing), the conventional focus on genetics and individual genes is now shifting toward the analysis of complex genes, gene-gene interactions and the association between genes and environment, including epigenetics. The rapidly changing scientific research landscape, with the ever-growing influx of data on one hand and emergence of newer and more complicated diseases on the other, has created a dilemma for researchers and caregivers, who are still hopeful that advances in genetics and genomics will provide avenues for the understanding, prevention and possible cure of human diseases. The book focuses on the interactions between genes and proteins at both the transcriptome and proteome levels, which in turn affect the human genome and health. Additionally, it covers the domain that must be explored in order to understand the gene-gene and protein-protein interactions that contribute to human health. The book offers a valuable guide for all students and researchers working in the area of molecular genetics and genomics.
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Rawal, Leena. \ed.\; Ali, Sher. \ed.\
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6.


   
    Introduction to Biomolecular Structure and Biophysics [Electronic resource] : basics of Biophysics / / ed. Misra, Gauri. - 1st ed. 2017. - [S. l. : s. n.]. - XVII, 274 p. 133 illus., 78 illus. in color. - ISBN 9789811049682
    Зміст:
Рубрики: Biomedical engineering.
   Biophysics.
   Biological physics.
   Nucleic acids.
   Proteins .
   Medical genetics.
   Biomedical Engineering/Biotechnology.
   Biological and Medical Physics, Biophysics.
   Nucleic Acid Chemistry.
   Protein Science.
   Gene Function.
   Protein-Ligand Interactions.
Анотація: This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small Angle X-ray Scattering (SAXS) and cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques used to study important biomolecules.
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Misra, Gauri. \ed.\
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7.


   
    Long Non Coding RNA Biology [Electronic resource] / ed. Rao, M.R.S. - 1st ed. 2017. - [S. l. : s. n.]. - XVI, 323 p. 34 illus., 32 illus. in color. - ISBN 9789811052033
    Зміст:
Рубрики: Gene expression.
   Developmental biology.
   Medical genetics.
   Nucleic acids.
   Gene Expression.
   Developmental Biology.
   Gene Function.
   Nucleic Acid Chemistry.
Анотація: This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
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Rao, M.R.S. \ed.\
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8.


   
    Plant Epigenetics [Electronic resource] / ed.: Rajewsky, Nikolaus., Jurga, Stefan., Barciszewski, Jan. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 536 p. 53 illus., 48 illus. in color. - ISBN 9783319555201
    Зміст:
Рубрики: Nucleic acids.
   Plant genetics.
   Agriculture.
   Biomedical engineering.
   Biotechnology.
   Nucleic Acid Chemistry.
   Plant Genetics and Genomics.
   Agriculture.
   Biomedical Engineering/Biotechnology.
   Biotechnology.
Анотація: This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.
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Rajewsky, Nikolaus. \ed.\; Jurga, Stefan. \ed.\; Barciszewski, Jan. \ed.\
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9.


   
    Trends in Bioelectroanalysis [Electronic resource] / ed. Matysik, Frank-Michael. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 344 p. 70 illus., 58 illus. in color. - ISBN 9783319484853
    Зміст:
Рубрики: Analytical chemistry.
   Electrochemistry.
   Nucleic acids.
   Proteins .
   Analytical Chemistry.
   Electrochemistry.
   Nucleic Acid Chemistry.
   Protein Science.
Анотація: This volume offers a careful selection of trend-setting topics in the field. In-depth review articles illustrate current trends in the field.  Experienced experts present a comprehensive overview concerning the electrochemical biosensing of glucose for diabetes care from an industrial research and development perspective a survey of bioassay applications for individually addressable electrochemical arrays, focusing on liquid-phase bioanalytical assays a review of recent advances in the development of electronic tongues based on the use of biosensor arrays coupled with advanced chemometric data analysis novel strategies of DNA biosensor development  and corresponding applications for studies of DNA damage a survey of recent trends in the electrochemistry of redox proteins, including the increasing diversity of redox proteins used in electrochemical studies, novel immobilization strategies, and biosensor / biofuel cell applications an overview of electrochemical sensing of blood gases with advanced sensor concepts a survey of recent bioelectroanalytical studies with high spatial resolution using scanning electrochemical microscopy with a  wide range of applications covering imaging of living cells, studies of metabolic activity, imaging of local enzyme activity, and studies of transport through biolayers This timely collection will be of interest not only for experts in the field, but also to students and their teachers in disciplines that include analytical chemistry, biology, electrochemistry, and various interdisciplinary research areas.
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10.


    Terasaka, Naohiro.
    Applications of Aminoacylation Ribozymes That Recognize the 3′-end of tRNA [Electronic resource] / Naohiro. Terasaka ; . - 1st ed. 2017. - [S. l. : s. n.]. - XII, 89 p. 38 illus., 28 illus. in color. - ISBN 9784431565178
    Зміст:
Рубрики: Bioorganic chemistry.
   Catalysis.
   Nucleic acids.
   Biotechnology.
   Bioorganic Chemistry.
   Catalysis.
   Nucleic Acid Chemistry.
   Biotechnology.
Анотація: In this thesis, applications of aminoacylation ribozymes named flexizymes are described. Flexizymes have the following unique characteristics: (i) substrate RNA is recognized by two consecutive base pairs between the 3'-end of substrate RNA and the 3'-end of the flexizyme; (ii) these base pairs can be substituted with other base pairs; and (iii) various activated amino acids can be used as substrates including both canonical and noncanonical amino acids. This flexible aminoacylation of RNAs by flexizymes was used to label endogenous tRNAs to be removed, and in vitro selection using the tRNA-depleted library enabled the discovery of the novel interaction between the microRNA precursor and metabolites. Flexizymes are also used to prepare various aminoacyl-tRNAs bearing mutations at the 3'-end to engineer the translation machinery and to develop the orthogonal translation machinery. The first part of the research demonstrated that SELEX is appropriate for discovering the interaction between small RNA and ligands, and suggested that more RNA motif binding to small molecules exists in small RNAs. The second part opened a door to new opportunities for in vitro synthetic biology involving the engineering of the genetic codes and translation machineries. This research also indicated the great potential of aminoacylation by flexizymes to be applied in various fields of RNA research, which is beneficial for RNA researchers.
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Terasaka, Naohiro. \.\
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11.


    Ježek, Jan.
    Biomedical Applications of Acridines [Electronic resource] : derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases / / Jan. Ježek, Hlaváček, Jan., Šebestík, Jaroslav. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 237 p. 79 illus., 25 illus. in color. - ISBN 9783319639536
    Зміст:
Рубрики: Medicinal chemistry.
   Neurochemistry.
   Pharmacology.
   Proteins .
   Bioorganic chemistry.
   Nucleic acids.
   Medicinal Chemistry.
   Neurochemistry.
   Pharmacology/Toxicology.
   Protein-Ligand Interactions.
   Bioorganic Chemistry.
   Nucleic Acid Chemistry.
Анотація: This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
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Hlaváček, Jan.; Šebestík, Jaroslav.; Ježek, Jan. \.\
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12.


    Prakash, Kirti.
    Chromatin Architecture [Electronic resource] : advances From High-resolution Single Molecule DNA Imaging / / Kirti. Prakash ; . - 1st ed. 2017. - [S. l. : s. n.]. - LIII, 152 p. 101 illus., 50 illus. in color. - ISBN 9783319521831
    Зміст:
Рубрики: Cell biology.
   Spectroscopy.
   Microscopy.
   Nucleic acids.
   Cell Biology.
   Spectroscopy and Microscopy.
   Nucleic Acid Chemistry.
   Spectroscopy/Spectrometry.
Анотація: This book sheds new light on the current state of knowledge concerning chromatin organization. Particular emphasis is given to the new imaging potential offered by super-resolution microscopy, which allows DNA imaging with a very high labeling density. From the early work on chromosomes by Walther Flemming in the nineteenth century to recent advances in genomics, the history of chromatin research now spans more than a century. The various milestones, such as the discovery of the double helix structure, the sequencing of the human genome, and the recent description of the genome in 3D space, show that understanding chromatin and chromosome function requires a clear understanding of its structure. Presenting cutting-edge data from super-resolution single molecule microscopy, the book demonstrates that chromatin manifests several levels of folding, from nucleosomes to chromosomes. Chromatin domains emerge as a new fundamental building block of chromatin architecture, with functions possibly related to gene regulation. A detailed description of chromatin folding in the pachytene stage of meiosis serves as a model for exploring this functionality, showing the apparent interplay between structure, function, and epigenetic regulation. Lastly, the book discusses possible new avenues of innovation to describe chromatin’s organization and functions. Gathering essential insights on chromatin architecture, the book offers students an introduction to microscopy and its application to chromatin organization, while also providing advanced readers with new ideas for future research.
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Prakash, Kirti. \.\
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