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    Nitrite and Nitrate in Human Health and Disease [Electronic resource] / ed.: Bryan, Nathan S., Loscalzo, Joseph. - 2nd ed. 2017. - [S. l. : s. n.]. - XXXI, 349 p. 48 illus., 35 illus. in color. - ISBN 9783319461892
    Зміст:

Рубрики: Clinical nutrition.
   Medical biochemistry.
   Ecotoxicology.
   Clinical Nutrition.
   Medical Biochemistry.
   Ecotoxicology.
Анотація: This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references. The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function. Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.
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Bryan, Nathan S. \ed.\; Loscalzo, Joseph. \ed.\
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    Gendering Drugs [Electronic resource] : feminist Studies of Pharmaceuticals / / ed. Johnson, Ericka. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 232 p. - ISBN 9783319514871
    Зміст:

Рубрики: Technology—Sociological aspects.
   Sociology.
   Social medicine.
   Human body—Social aspects.
   Medical biochemistry.
   Science and Technology Studies.
   Gender Studies.
   Medical Sociology.
   Sociology of the Body.
   Medical Biochemistry.
Анотація: This book, by bringing together critical pharmaceutical studies and feminist technoscience studies, explores the way drugs produce sexed and/or gendered identities for those who take – or resist – them, and how feminist technoscience studies can contribute a theoretical lens with which to observe sex and gender in the pharmaceuticalization processes. Topics explored in this diverse collection include the use of hormones to delay puberty onset for trans children; HPV vaccination against cervical cancer in Sweden, the UK, Austria and Colombia; Alzheimer’s discourses; and the medication of prostate issues. Ericka Johnson has brought together an innovative and timely collection that demonstrates gender as relevant in studies of pharmaceuticals, and provides multiple examples of methodological and theoretical tools to consider gender while studying drugs.
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Johnson, Ericka. \ed.\
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    Future Directions in Metalloprotein and Metalloenzyme Research [Electronic resource] / ed.: Hanson, Graeme., Berliner, Lawrence. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 191 p. 80 illus., 59 illus. in color. - ISBN 9783319591001
    Зміст:

Рубрики: Enzymology.
   Medical biochemistry.
   Biomaterials.
   Enzymology.
   Medical Biochemistry.
   Biomaterials.
Анотація: This book covers the latest developments in metalloenzymes, including characterizing metal bridging in proteins and peptides, copper(II) complexes of marine peptides, high-spin Co(II) in model and metalloprotein systems to enzymes such as the molybdenum-containing enzymes, CW and pulse EPR of cytochrome P450 enzymes and the radical S-adenosylmethionine FeS family. In the previous two related volumes in the Biological Magnetic Resonance series, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine and Metals in Biology:Applications of High-Resolution EPR to Metalloenzymes, topics covered included high-resolution EPR methods, iron proteins, nickel and copper enzymes, metals in medicine, iron–sulfur cluster-containing proteins, and molybdenum enzymes. In this volume, new developments in these areas are covered in detail and new areas that have emerged are also detailed. This is an ideal book for graduate students and researchers working in the fields of high-resolution EPR, metalloenzymes, and metals in biology.
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Hanson, Graeme. \ed.\; Berliner, Lawrence. \ed.\
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    Devasena, T.
    Therapeutic and Diagnostic Nanomaterials [Electronic resource] / T. Devasena ; . - 1st ed. 2017. - [S. l. : s. n.]. - VII, 109 p. 25 illus., 2 illus. in color. - ISBN 9789811009235
    Зміст:

Рубрики: Biomedical engineering.
   Biomaterials.
   Molecular biology.
   Nanotechnology.
   Medical biochemistry.
   Biochemical engineering.
   Biomedical Engineering and Bioengineering.
   Biomaterials.
   Molecular Medicine.
   Nanotechnology and Microengineering.
   Medical Biochemistry.
   Biochemical Engineering.
Анотація: This brief highlights nanoparticles used in the diagnosis and treatment of prominent diseases and toxic conditions. Ecofriendly methods which are ideal for the synthesis of medicinally valued nanoparticles are explained and the characteristic features of these particles projected. The role of these particles in the therapeutic field, and the induced biological changes in some diseases are discussed. The main focus is on inflammation, oxidative stress and cellular membrane integrity alterations. The effect of nanoparticles on these changes produced by various agents are highlighted using in vitro and in vivo models. The mechanism of nanoparticles in ameliorating the biological changes is supported by relevant images and data. Finally, the brief demonstrates recent developments on the use of nanoparticles in diagnosis or sensing of some biological materials and biologically hazardous environmental materials.
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Devasena T. \.\
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    Feng, Tao.
    Nanomaterial-Based Drug Delivery Carriers for Cancer Therapy [Electronic resource] / Tao. Feng, Zhao, Yanli. ; . - 1st ed. 2017. - [S. l. : s. n.]. - IX, 55 p. 35 illus., 32 illus. in color. - ISBN 9789811032998
    Зміст:

Рубрики: Biomedical engineering.
   Cancer research.
   Biomaterials.
   Nanotechnology.
   Molecular biology.
   Medical biochemistry.
   Biomedical Engineering and Bioengineering.
   Cancer Research.
   Biomaterials.
   Nanotechnology and Microengineering.
   Molecular Medicine.
   Medical Biochemistry.
Анотація: This brief summarizes different types of organic and inorganic nanomaterials for drug delivery in cancer therapy. It highlights that precisely designed nanomaterials will be the next-generation therapeutic agents for cancer treatment.
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Zhao, Yanli.; Feng, Tao. \.\
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    Khashayar, Patricia.
    Point-of-Care Solution for Osteoporosis Management [Electronic resource] : design, Fabrication, and Validation of New Technology / / Patricia. Khashayar ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXIV, 197 p. 180 illus., 151 illus. in color. - ISBN 9783319550534
    Зміст:

Рубрики: Biomedical engineering.
   Medical biochemistry.
   Biochemical engineering.
   Nanotechnology.
   Biomedical Engineering and Bioengineering.
   Biomedical Engineering/Biotechnology.
   Medical Biochemistry.
   Biochemical Engineering.
   Nanotechnology and Microengineering.
Анотація: This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.
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Khashayar, Patricia. \.\
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    Banerjee, Ena Ray.
    Perspectives in Translational Research in Life Sciences and Biomedicine [Electronic resource] : translational Outcomes Research in Life Sciences and Translational Medicine, Volume 2 / / Ena Ray. Banerjee ; . - 1st ed. 2017. - [S. l. : s. n.]. - XII, 132 p. 32 illus., 22 illus. in color. - ISBN 9789811058707
    Зміст:

Рубрики: Regenerative medicine.
   Tissue engineering.
   Molecular biology.
   Gene therapy.
   Animal models in research.
   Medical biochemistry.
   Regenerative Medicine/Tissue Engineering.
   Molecular Medicine.
   Gene Therapy.
   Animal Models.
   Medical Biochemistry.
Анотація: This book is a collation of translational research outcomes in the area of life research, which was formerly used mainly for academic pursuits. The studies described focus on innovative interdisciplinary approaches to unraveling problems in life sciences and biomedicine using biodiversity exploration and green technology. The techniques and models presented offer a ready reckoner for researchers in academic institutions and industry, and also provide valuable insights into fundamental research. The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how combination cultures of commensalistic bacteria can help boost immunity; development of functional food from natural products from plant, animal, and microbial sources in the nutraceuticals domain; as well as synthesis and mechanisms in nanomedicine and nanoscaffolds in biomedicine. The studies and discourses described touch upon topics that explore biodiversity for the development of disease models, toxicity studies, developmental studies, and harvesting of bioactive compounds for alternative income generation and poverty alleviation, and as a result, bring about economic and ecologic sustainability. This multidimensional and multidisciplinary book focuses on tissue-specific targeting by nanodrugs, development of bioengineering formats for cell- based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and syndromes.
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Banerjee, Ena Ray. \.\
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    Immunopathology in Toxicology and Drug Development [Electronic resource] : volume 1, Immunobiology, Investigative Techniques, and Special Studies / / ed. Parker, George A. - 1st ed. 2017. - [S. l. : s. n.]. - XXII, 670 p. 255 illus., 250 illus. in color. - ISBN 9783319473772
    Зміст:

Рубрики: Pathology.
   Immunology.
   Pharmaceutical technology.
   Medical biochemistry.
   Pathology.
   Immunology.
   Pharmaceutical Sciences/Technology.
   Medical Biochemistry.
Анотація: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
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Parker, George A. \ed.\
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    Phytocannabinoids [Electronic resource] : unraveling the Complex Chemistry and Pharmacology of Cannabis sativa / / ed. Kinghorn, A. Douglas. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 131 p. 73 illus., 33 illus. in color. - ISBN 9783319455419
    Зміст:

Рубрики: Organic chemistry.
   Medicinal chemistry.
   Medical biochemistry.
   Organic Chemistry.
   Medicinal Chemistry.
   Medical Biochemistry.
Анотація: The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.
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Kinghorn, A. Douglas. \ed.\; Falk, Heinz. \ed.\; Gibbons, Simon. \ed.\; Kobayashi, Jun'ichi. \ed.\
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10.

    Taurine 10 [Electronic resource] / ed. Lee, Dong-Hee. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XXV, 1212 p. 400 illus., 93 illus. in color. - ISBN 9789402410792
    Зміст:

Part I Taurine and Brain Health -- Is Taurine a Biomarker in Autistic Spectrum Disorder?.-Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development -- Taurine Supplementation Reduces Renal Nerve Activity in Male Rats in Which Renal Nerve Activity was Increased by a High Sugar Diet -- Taurine Recovery of Learning Deficits Induced by Gestational Pb+ Exposure -- Comparison of Urinary Excretion of Taurine between the Elderly with Dementia and the Normal Elderly -- Past Taurine Intake Has A Positive Effect on Present Cognitive Function in The Elderly -- Dietary Taurine Supplementation in School Meal Has a Positive Effect On School Attitude Assessment in Korean High School Students -- Significance of Taurine in the Brain -- Neuroprotection by Taurine on HBCD-induced Apoptosis in PC12 Cells -- Taurine Alleviate Hexabromocyclododecane-Induced Cytotoxicity in PC12 Cells via Inhibiting Oxidative Stress -- Effects of Taurine On Alterations Of Neurobehavior and Neurodevelopment Key Proteins Expression in Infant Rats by Exposure to Hexabromocyclododecane -- Taurine Chloramine Suppresses Lipopolysaccharide-Induced Neuroinflammatory Responses -- NRF2-Mediated Heme Oxygenase-1 Expression In Mouse BV2 Microglial Cells -- Taurine Chloramine Prevents Neuronal HT22 Cell Damage through NRF-2 Related Heme Oxygenase-1 -- Taurine Have Neuroprotective Activity against Oxidative Damage-Induced HT22 Cell Death Through Heme Oxygenase-1 Pathways -- Ethanol-Induced Taurine Elevation in the Rat Dorsal Striatum -- Taurine Ameliorates Arsenic-induced Apoptosis In The Hippocampus Of Mice Through Intrinsic Pathway -- Neuroprotective Functions Through Inhibition of ER Stress By Taurine or Taurine Combination Treatments in a Rat Stroke Model -- Analysis of Neuroprotection By Taurine And Taurine Combinations In Primary Neuronal Cultures And In Neuronal Cell Lines Exposed To Glutamate Excitotoxicity And To Hypoxia /Re-Oxygenation -- Minor Adaptations Of Ethanol-Induced Release Of Taurine Following Chronic Ethanol Intake In The Rat -- Taurine-Carbohydrate Derivative Stimulates Fibrillogenesis Of Amyloid-β And Reduce Alzheimer-Like Behaviors -- Taurine Directly Binds To Oligomeric Amyloid-β And Recovers Cognitive Deficits In Alzheimer Model Mice -- Neuroprotective Effect Of Taurine-Rich Cuttlefish (Sepia Officinalis) Extract Against Hydrogen Peroxide-Induced Oxidative Stress In SH-SY5Y Cells -- Protection Of Taurine Against Impairment In Learning And Memoryin Mice Exposed To Arsenic -- Effects Of Taurine Supplementation On Neuronal Hyper Excitability And Glucose Homeostasis -- Putative Role Of Taurine As Neurotransmitter During Perinatal Cortical Development -- Part Ⅱ Effects of Taurine on Obesity and Diabetes -- Perinatal Taurine Supplementation Prevents Metabolic And Cardiovascular Effects Of Maternal Diabetes In Adult Rat Offspring -- Taurine Improves Sexual Function In Streptozotocin-induced Diabetic Rats -- Taurine increase insulin expression STZ-treated rats islet cells in vitro -- Metabolomics profiling of the effects of taurine supplementation on dyslipidemia in a high-fat-diet-induced rat model by 1 H NMR spectroscopy -- The effect of taurine and its immediate homologs on diabetes-induced oxidative stress in the brain and spinal cord of rats -- The effect of metformin and taurine, alone and in combination, on the oxidative stress caused by diabetes in the rats brain -- Investigation of the role of a supplementation with taurine on the effects of hypoglycemic-hypotensive therapy against diabetes-induced nephrotoxicity in rats -- Part Ⅲ Taurine for Energy Production and Muscle -- Increased N-Acetyltaurine in the Skeletal Muscle after endurance exercise in Rat -- Gestational protein restriction in Wistar rats; effect of taurine supplementation on properties of newborn skeletal muscle -- Impaired Energy Production contributes to Development of Failure in Taurine Deficient Heart -- Part Ⅳ. Taurine Deficiency and Knockout of Taurine -- A novel cysteine sulfinic acid decarboxylase knock-out mouse: immune function (II) -- A novel cysteine sulfinic acid decarboxylase knock-out mouse: taurine distribution in various tissues with and without taurine supplementation -- Identification of taurine-responsive genes in murine liver using the Cdo1-null mouse model -- Beta-catenin and SMAD3 are associated with skeletal muscle aging in the taurine transporter knockout mouse -- Glucose homeostasis and retinal histopathology in CSAD KO mice -- Part Ⅴ Biology and Chemistry of Taurine Derivatives -- Comparative analysis of microbicidal and anti-inflammatory properties of novel taurine bromamine derivatives and bromamine T -- HPLC determination of Bioactive sulfur compounds, amino acids and biogenic amines in biological specimens -- Carbonate anion radical generated by the peroxidase activity of copper-zinc superoxide dismutase: scavenging of radical and protection of enzyme by hypotaurine and cysteine sulfinic acid -- A proteomic approach to study the effect of thiotaurine on human neutrophil activation -- The interaction of hypotaurine and other sulfinates with reactive oxygen and nitrogen species: a survey of reaction mechanisms -- Protective effects of a Water extracts prepared from Loliolus beka Gray meet against -- H_2 O_2-induced oxidative stress in Chang liver cells and Zebrafish embryo model -- Protective effects of an enzymatic hydrolysate from Octopus ocellatus meet against HYDROGEN PEROXIDE-induced oxidative stress in Chang liver cells and Zebrafish embryo -- Hepatoprotective effects of Xylose-Taurine reduced against hydrogen peroxide-induced oxidative stress in cultured hepatocytes -- Xylose-Taurine reduced suppresses the inflammatory responses in lipopolysaccharide-stimulated RAW 264.7 macrophages -- Protective effects of Xylose-Taurine reduced against damages caused by oxidative stress in zebrafish embryos in vivo model -- Anti-inflammatory effects of Galactose-Taurine sodium salt, a taurine derivate in zebrafish embryos in vivo model -- Effect of of N-(D- Ribopyranosyl) Taurine sodium salt on differentiation of human preadipocytes and expression of adipokines through inhibition of STAT-3 signaling in differentiated human adipocytes -- Synthesis of N-chloroamino acids and their biological activities in LPS stimulated RAW 264.7 cells -- Part Ⅵ Effects of Taurine on Organ Disorders -- Taurine promotes retinal ganglion cell survival through GABAB receptor activation -- Taurine administration mitigates cisplatin-induced nephrotoxicity by decreasing oxidative DNA damage and inflammation : an immunocytochemical study -- Effect of taurine on iNOS-mediated DNA damage in drug-induced renal injury -- Effect of radiation on the expression of taurine transporter in the intestine of mouse -- Taurine supplementation ameliorates the adverse effects of perinatal taurine depletion and high sugar intake on cardiac ischemia/reperfusion in adult female rats -- Perinatal taurine supplementation alters renal function via renin-angiotensin system overactivity in adult female rats -- Perinatal taurine imbalance followed by high sugar intake alters the effect of estrogen on renal excretory function in adult female rats -- Taurine inhibits Kupffer cells activation induced by Lipopolysaccharide in Alcoholic liver damaged rats -- Taurine recovers testicular steroidogenesis and spermatogenesis in streptozotocin-induced diabetic rats -- Effects of taurine and L-arginine on the apoptosis of vascular smooth muscle cellular apoptosis in insulin resistance hypertensive rats -- Taurine prevents the electrical remodeling Ach-CaCl2 Induced Atrial Fibrillation in rats -- Taurine reverses atrial structural remodeling in Ach-CaCl2 induced atrial fibrillation rats -- Taurine normalizes the levels of Se, Cu, Fe in mouse liver and kidney subchronically exposed to arsenic subchronically -- Taurine protects mouse liver against arsenic induced apoptosis through JNK signaling -- Taurine attenuates 〖AS〗_2 O_3-induced autophagy in cerebrum of mouse through NRF2 pathway -- Effects of taurine on ACE, ACE2 and HSP70 of expression of hypothalamic-pituitary adrenal axis in stress-induced hypertensive rats -- Taurine protects glutamate neurotoxicity in motor neuron cells -- Role of taurine in BDE 209-induced oxidative stress in PC12 cells -- Protection of taurine against PFOS-induced neurotoxicity in PC12 cells -- Protection of Taurine against Arsenic-Induced DNA Damage of Mice Kidneys -- Part Ⅶ Effects of Taurine on Immunity -- Mussel (Mytilus Coruscus) water extract containing taurine prevents LPS-induced inflammatory responses in Zebrafish model -- Anti-inflammatory effects of Galactose-Taurine sodium salt in LPS-activated RAW 264.7 cells -- Radio-protective effects of Octopus ocellatus meat consisted of a plentiful taurine against damages caused by gamma ray irradiation -- Part Ⅷ Taurine in Nutrition -- The Effect on Blood Biochemical factors of a ICR-mice in a High-fat Diet with Taurine 20% -- Effects of replacement of methionine in diets with taurine on growth performance and Blood index in Broilers -- Consumer awareness and preferences Related to Taurine- containing drinks in Korean female high school students -- Taurine Intake with Magnesium Reduces Cardiometabolic Risks -- Comparison of toxicity of taurine and GABA in combination with alcohol in 7-Day-old mice -- Antioxidant effects of short-neck CLAM(TAPES PHILIPPINARUM) water extract containing Taurine against AAPH-induced oxidative stress in zebrafish embroys -- Role for taurine in development of oxidative metabolism after birth -- Beneficial function of taurine on bone metabolism in Alcohol-fed OVX rat model -- Liver antioxidant enzyme activities after Taurine in ovariectomized rats -- Effects of Taurine and Vitamin D on Antioxidant Enzyme Activity and Lipid profiles in Rats Fed Diet Deficient Calcium -- Taurine may modulates bone in Cholesterol Fed Estrogen Deficiency-Induced Rats -- Part.

Рубрики: Proteins .
   Proteomics.
   Human genetics.
   Medical biochemistry.
   Human physiology.
   Protein Science.
   Proteomics.
   Human Genetics.
   Medical Biochemistry.
   Human Physiology.
Анотація: This volume provides the reader with an overview of taurine and its derivatives in modulating brain health. One of the highlights of this book is that taurine helps in the recovery of Alzheimer model mice from cognitive deficits by directly binding to oligomeric β-amyloid. In addition, this book includes very intriguing results from a study that looks into the effects of taurine-carbohydrate derivatives in stimulating fibrillogenesis of amyloid-b and in reducing Alzheimer-like behaviors. This book also highlights several new roles for taurine, including its novel effects on the various body structures encompassing the central nervous system, the cardiovascular system, the immune system, and the endocrine system, along with a role for taurine complements in nutrition. This edited book contains original articles and reviews based on oral and poster presentations at the 20th International Taurine Meeting held in Seoul, Korea in May 2016. The theme of this conference was ‘Taurine and Brain Health’. This volume will be relevant to anyone with an interest in the biological roles of taurine, from clinicians to nutritionists and from individuals working in the pharmaceutical industry to those working in food manufacturing.
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Lee, Dong-Hee. \ed.\; Schaffer, Stephen W. \ed.\; Park, Eunkyue. \ed.\; Kim, Ha Won. \ed.\
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11.

    Scott, L. Ridgway.
    A Mathematical Approach to Protein Biophysics [Electronic resource] / L. Ridgway. Scott, Fernández, Ariel. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XI, 290 p. 110 illus., 27 illus. in color. - ISBN 9783319660325
    Зміст:

Рубрики: Biomathematics.
   Systems biology.
   Biological systems.
   Proteins .
   Medical biochemistry.
   Mathematical and Computational Biology.
   Systems Biology.
   Protein Science.
   Medical Biochemistry.
Анотація: This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way. This book will help readers to understand how certain biological systems involving proteins function as digital information systems despite the fact that underlying processes are analog in nature. The in-depth explanation of proteins from a quantitative point of view and the variety of level of exercises (including physical experiments) at the end of each chapter will appeal to graduate and senior undergraduate students in mathematics, computer science, mechanical engineering, and physics, wanting to learn about the biophysics of proteins. L. Ridgway Scott has been Professor of Computer Science and of Mathematics at the University of Chicago since 1998, and the Louis Block Professor since 2001. He obtained a B.S. degree (Magna Cum Laude) from Tulane University in 1969 and a PhD degree in Mathematics from the Massachusetts Institute of Technology in 1973. Professor Scott has published over 130 papers and three books, extending over biophysics, parallel computing and fundamental computing aspects of structural mechanics, fluid dynamics, nuclear engineering, and computational chemistry. Ariel Fernández (born Ariel Fernández Stigliano) is an Argentinian-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University and held the Karl F. Hasselmann Endowed Chair Professorship in Bioengineering at Rice University. He is currently involved in research and entrepreneurial activities at various consultancy firms. Ariel Fernández authored three books on translational medicine and biophysics, and published 360 papers in professional journals. He holds two patents in the field of biotechnology.
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Fernández, Ariel.; Scott, L. Ridgway. \.\
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12.

    Annesini, Maria Cristina.
    Artificial Organ Engineering [Electronic resource] / Maria Cristina. Annesini, Marrelli, Luigi., Piemonte, Vincenzo., Turchetti, Luca. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XV, 265 p. 107 illus., 26 illus. in color. - ISBN 9781447164432
    Зміст:

Рубрики: Biomedical engineering.
   Medical biochemistry.
   Biochemical engineering.
   Biophysics.
   Biological physics.
   Biomedical Engineering and Bioengineering.
   Medical Biochemistry.
   Biochemical Engineering.
   Biological and Medical Physics, Biophysics.
Анотація: Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental physico-chemical phenomena involved in the process, the whole system is rebuilt as an interconnected ensemble of elemental unit operations. Each artificial organ is presented with a short introduction provided by expert clinicians. Devices commonly used in clinical practice are reviewed and their performance is assessed and compared by using a mathematical model based approach. Whilst mathematical modelling is a fundamental tool for quantitative descriptions of clinical devices, models are kept simple to remain focused on the essential features of each process. Postgraduate students and researchers in the field of chemical and biomedical engineering will find that this book provides a novel and useful tool for the analysis of existing devices and, possibly, the design of new ones. This approach will also be useful for medical researchers who want to get a deeper insight into the basic working principles of artificial organs.
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Marrelli, Luigi.; Piemonte, Vincenzo.; Turchetti, Luca.; Annesini, Maria Cristina. \.\
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13.

    Jain, Kewal K.
    Textbook of Hyperbaric Medicine [Electronic resource] / Kewal K. Jain ; . - 6th ed. 2017. - [S. l. : s. n.]. - XLVIII, 640 p. 171 illus., 83 illus. in color. - ISBN 9783319471402
    Зміст:

Part I. Basic Aspects -- Chapter 1. The History of Hyperbaric Medicine -- Chapter 2. Physical, Physiological, and Biochemical Aspects of Hyperbaric Oxygenation -- Chapter 3. Effects of Diving and High Pressure on the Human Body -- Chapter 4. Physical Exercise under Hyperbaric Conditions -- Chapter 5. Hypoxia -- Chapter 6. Oxygen Toxicity -- Chapter 7. Hyperbaric Chambers: Equipment, Technique, and Safety -- Chapter 8. Indications, Contraindications, and Complications of HBO Therapy -- Chapter 9. Drug Interactions with Hyperbaric Oxygenation -- Chapter 10. Neurophysiologic SPECT Brain Function Imaging and Hyperbaric Oxygen Therapy -- Part II. Clinical Applications -- Chapter 11. Decompression Sickness -- Chapter 12. Cerebral Air Embolism -- Chapter 13. Carbon Monoxide and Other Tissue Poisons -- Chapter 14. HBO Therapy in Infections -- Chapter 15. Hyperbaric Oxygen Therapy and Chronic Lyme Disease: The Controversy and the Evidence -- Chapter 16. HBO Therapy in Wound Healing, Plastic Surgery, and Dermatology -- Chapter 17. HBO Therapy in the Management of Radionecrosis -- Chapter 18. The Use of HBO in Treating Neurological Disorders -- Chapter 19. Role of Hyperbaric Oxygenation in the Management of Stroke -- Chapter 20. HBO Therapy in Global Cerebral Ischemia/Anoxia and Coma -- Chapter 21. HBO Therapy in Neurosurgery -- Chapter 22. Oxygen Treatment for Multiple Sclerosis Patients -- Chapter 23. HBO in the Management of Cerebral Palsy -- Chapter 24. HBO Therapy in Miscellaneous Neurological Disorders -- Chapter 25. HBO Therapy in Cardiovascular Diseases -- Chapter 26. HBO Therapy in Hematology and Immunology -- Chapter 27. HBO Therapy in Gastroenterology -- Chapter 28. HBO and Endocrinology -- Chapter 29. HBO and Pulmonary Disorders -- Chapter 30. Hyperbaric Oxygenation in Traumatology and Orthopedics -- Chapter 31. HBO Therapy in Otolaryngology -- Chapter 32. HBO Therapy and Ophthalmology -- Chapter 33.Hyperbaric Oxygenation in Obstetrics and Gynecology -- Chapter 34. Use of Hyperbaric Oxygenation (HBO2) in Neonatal Patients -- Chapter 35. Hyperbaric Oxygenation in Geriatrics -- Chapter 36. HBO as an Adjuvant in Rehabilitation and Sports Medicine -- Chapter 37. Nursing and Hyperbaric Medicine -- Chapter 38. Role of HBO in Enhancing Cancer Radiosensitivity -- Chapter 39. HBO Therapy and Organ Transplants -- Chapter 40. Hyperbaric Oxygen Pretreatment and Preconditioning -- Chapter 41. Anesthesia in the Hyperbaric Environment -- Chapter 42. Hyperbaric Oxygen in Resuscitation -- Chapter 43. HBO in Military Medicine -- Part III. Hyperbaric Medicine as a Specialty -- Chapter 44. Training and Practice of Hyperbaric Medicine -- Chapter 45. Research in Hyperbaric Medicine -- Chapter 46. Personalized Hyperbaric Medicine -- Chapter 47. The Future of Hyperbaric Medicine -- Chapter 48. Ethical Issues, Standards, and Quality Control in the Practice of Hyperbaric Medicine -- Chapter 49. Hyperbaric Medicine in Europe -- Chapter 50. Hyperbaric Medicine in the United States -- Chapter 51. Hyperbaric Medicine in Latin America.

Рубрики: Internal medicine.
   Medical biochemistry.
   Rehabilitation.
   Internal Medicine.
   Medical Biochemistry.
   Rehabilitation.
Анотація: This comprehensive volume captures the latest scientific evidence, technological advances, treatments and impact of biotechnology in hyperbaric oxygen therapy. Divided into three distinct sections, the book begins with basic aspects that include history, equipment, safety and diagnostic approaches; this is followed by clinical applications for hyperbaric oxygen therapy in various modalities; the last section provides an overview of hyperbaric medicine as a specialty with best practices from around the world. Integration of multidisciplinary approaches to complex disorders are also covered. Updated and significantly expanded from previous editions, Textbook of Hyperbaric Medicine, 6th Edition will continue to be the definitive guide to this burgeoning field for students, trainees, physicians and specialists. .
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Jain, Kewal K. \.\
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14.

    Store-Operated Ca²⁺ Entry (SOCE) Pathways [Electronic resource] : emerging Signaling Concepts in Human (Patho)physiology / / ed.: Groschner, Klaus., Graier, Wolfgang F., Romanin, Christoph. - 2nd ed. 2017. - [S. l. : s. n.]. - XXIX, 645 p. 84 illus., 62 illus. in color. - ISBN 9783319577326
    Зміст:

Part 1. SOCE - Fundamental Mechanistic Concepts -- 1. Introduction -- 2. STIM/Orai Structures: Isolated and in Complex -- 3. Orai, the Pore-Forming Subunit of the CRAC Channel -- 4. The Interactions between STIM and Orai -- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry -- 6. Regulation of STIM and Orai by Thiol Modifications -- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels -- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes -- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function -- 10. Auxiliary Proteins of the STIM/Orai Complex -- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments -- 11. Introduction -- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE -- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores -- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+ Entry and Mitochondria -- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry -- 16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry -- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling -- 18. Tissue specificity SOCE – Implications for Ca2+ Handling in Endothelial Cells -- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes -- Part 3. SOCE - Molecular and Cellular (Patho) Physiology -- 20. Introduction -- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes -- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders -- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction -- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells – Emerging Targets for Therapeutic Intervention -- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology -- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology -- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function -- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle -- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation -- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease -- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.

Рубрики: Cell biology.
   Medical biochemistry.
   Biophysics.
   Biological physics.
   Cardiology.
   Cell Biology.
   Medical Biochemistry.
   Biological and Medical Physics, Biophysics.
   Cardiology.
Анотація: This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences.
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Groschner, Klaus. \ed.\; Graier, Wolfgang F. \ed.\; Romanin, Christoph. \ed.\
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15.

    Free Fatty Acid Receptors [Electronic resource] / ed.: Milligan, Graeme., Kimura, Ikuo. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 256 p. 70 illus. - ISBN 9783319506937
    Зміст:

Рубрики: Pharmacology.
   Human physiology.
   Diabetes.
   Systems biology.
   Medical biochemistry.
   Pharmacology/Toxicology.
   Human Physiology.
   Diabetes.
   Systems Biology.
   Medical Biochemistry.
Анотація: This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
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Milligan, Graeme. \ed.\; Kimura, Ikuo. \ed.\
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16.

    Immunopathology in Toxicology and Drug Development [Electronic resource] : volume 2, Organ Systems / / ed. Parker, George A. - 1st ed. 2017. - [S. l. : s. n.]. - XXII, 826 p. 255 illus., 250 illus. in color. - ISBN 9783319473857
    Зміст:

Рубрики: Pathology.
   Immunology.
   Pharmaceutical technology.
   Medical biochemistry.
   Pathology.
   Immunology.
   Pharmaceutical Sciences/Technology.
   Medical Biochemistry.
Анотація: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
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Parker, George A. \ed.\
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17.

    Protein and Sugar Export and Assembly in Gram-positive Bacteria [Electronic resource] / ed.: Bagnoli, Fabio., Rappuoli, Rino. - 1st ed. 2017. - [S. l. : s. n.]. - X, 337 p. - ISBN 9783319560144
    Зміст:

Рубрики: Medical microbiology.
   Medical biochemistry.
   Molecular biology.
   Medical Microbiology.
   Medical Biochemistry.
   Molecular Medicine.
Анотація: This book focuses on the envelope of Gram-positive bacteria including its composition, the latest discoveries in the mechanisms behind its assembly, and its role in pathogenesis. Furthermore, new applications in biotechnology and vaccine development involving these bacteria are discussed in detail. This concise volume consists of eleven chapters by prominent experts in the field, which review the latest findings and current state of knowledge on a range of diverse yet interlinked aspects. This book is written for all researchers, clinicians and technicians engaged in basic or applied science projects on Gram-positive bacteria. .
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Bagnoli, Fabio. \ed.\; Rappuoli, Rino. \ed.\
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18.

    Diet, Nutrition, and Fetal Programming [Electronic resource] / ed.: Rajendram, Rajkumar., Preedy, Victor R., Patel, Vinood B. - 1st ed. 2017. - [S. l. : s. n.]. - XXXIX, 621 p. 154 illus., 111 illus. in color. - ISBN 9783319602899
    Зміст:

Part I: Maternal Diet, Health and the Fetus: General Considerations -- Prenatal Maternal Stress in the Context: Maternal Stress Physiology, Immunology, Neuroendocrinology, Nutrition and Infant Development -- The Effects of Parental Diet on Fetal Programming of Stress-Related Brain Regions and Behaviors: Implications for Development of Neuropsychiatric Disorders -- Maternal Nutrition and Cognition -- Maternal Characteristics predisposing to Fetal Growth Restriction -- Maternal Insulin Sensitivity and Fetal Brain Activity -- Part II: Maternal Undernutrition and Protein Restriction: Effects on Fetus -- Dietary Restriction and the Endocrine Profiles in Offspring and Adults -- Maternal Undernutrition and Visceral Adiposity -- Maternal Undernutrition and Long-term Effects on Hepatic Function -- Maternal Protein Restriction and its Effects on Heart -- Effects of Maternal Protein Restriction on Nephrogenesis and Adult and Aging Kidney -- Maternal Protein Restriction and Effects on Behavior and Memory in Offspring -- Part III: Effects of Obesity, High Fat Diet and Junk Food on Fetal Outcomes -- Trends in Obesity and Implications for the Fetus -- Maternal Obesity and Implications for Fetal Programming -- Ethnicity, Obesity, and Pregnancy Outcomes on Fetal Programming -- Obesogenic Programming of Foetal Hepatic Metabolism by MircoRNAs -- Impacts of Maternal High Fat Diet on Stree-related Behavior and the Endocrine Response to Stress in Offspring -- Materna; Junk Food Diets: The Effects on Offspring Fat Mass and Food Preferences -- Part IV: Specific Dietary Components -- Maternal Fish Intake During Pregnancy and Effects on the Offspring -- Maternal Fish Oil Intake and Insulin Resistance in the Offspring -- Maternal n-3 Fatty Acids and Blood Pressure in Children -- Maternal Folate, Methyl Donors, One Carbon Metabolism, Vitamin B12 and Choline in Fetal Programming -- Maternal Taurine Supplementation Prevents Misprogramming -- Fetal Programming: Maternal Diets, Tryptophan and Postnatal Development -- Intrauterine Programming and Effects of Caffeine -- Part V: International Aspects and Policies -- Famines, Pregnancy and Effect on the Adults -- Maternal Malnutrition, Fetal Programming, Outcomes and Strategies in India -- Maternal Nutritional Factors Dictating Birth Weights: African Perspectives -- Maternal Nutrition in Ireland: Issues of Public Concern -- Maternal Malnutrition, Fetal Programming, Outcomes, and Implications of Environmental Factors in Japan -- Part VI: Effects of Fetal Programming in Childhood and Adulthood -- Growth Criteria and Predictors of Fetal Programming -- Effects of Fetal Programming on Metabolic Syndrome -- Fetal Programming of Food Preferences and Feeding Behavior -- Effects of Fetal Programming on Osteoporosis -- Childhood Sleep after Fetal Growth Restriction -- Part VII: Mechanisms of Programming -- Biomarkers of Abnormal Birth Weight in Pregnancy -- Mechanisms of Programming: Pancreatic Islets and Fetal Programming -- Pancratic GABA and Serotonin Actions in the Pancreas and Fetal Programming of Metabolism -- Maternal Malnutrition, Glucocorticoids and Fetal Programming: A Role for Placental 11β-hydroxysteroid dehydrogenase Type 2 -- High-fat Diet and Fetal Programming: Use of p66Shc Knockouts and Implications for Human Kind -- Fetal Programming of Telomere Biology: Role of Maternal Nutrition, Obstetric Risk Factors and Suboptimal Birth Outcomes. Part VIII: Resources -- Current Research and Recommended Resources on Fetal Nutrition.

Рубрики: Clinical nutrition.
   Medical biochemistry.
   Maternal and child health services.
   Clinical Nutrition.
   Medical Biochemistry.
   Maternal and Child Health.
Анотація: This volume offers the most comprehensive coverage on fetal programming. Chapters are written by authors of international and national standing, leaders in the field and trendsetters. The clinical relevance of the current research is emphasized in each chapter, which also contains key points, key words, and concise summaries for ease of learning. Fetal programming affects conditions in the immediate postnatal period, as well as in later life and adulthood. These conditions include cardiovascular disease, frank hypertension, stroke, dyslipidemia, coagulopathy, increased insulin resistance-metabolic syndrome, type-2 diabetes, leukemia, testicular cancer, prostate cancer, breast cancer, polycystic ovary syndrome, precocious puberty, impaired immune function, renal disease, lung disease, and osteoporosis. Neuropathologies, behavioral and mental deficiencies, schizophrenia, and depression have also been reported in adults who were exposed to nutritional inadequacies in utero. Diet, Nutrition and Fetal Programming provides an overview on the effects of fetal programming on disease, and comprehensive looks at maternal nutrition factors and fetal programming effects on brain and behavior, and physiology and disease. It also provides an in depth look at specific nutrient restrictions and supplements on physiology and disease, the effects of maternal disease on fetal programming, mechanisms of programming, and a special section on the international aspects and policies on fetal programming.
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Rajendram, Rajkumar. \ed.\; Preedy, Victor R. \ed.\; Patel, Vinood B. \ed.\
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19.

    Tasnim, Nishat.
    Frontiers in Nano-therapeutics [Electronic resource] / Nishat. Tasnim, Nair, Baiju G. [et al.] ; . - 1st ed. 2017. - [S. l. : s. n.]. - XVI, 82 p. 28 illus., 12 illus. in color. - ISBN 9789811032837
    Зміст:

Рубрики: Biomedical engineering.
   Nanotechnology.
   Biomaterials.
   Molecular biology.
   Medical biochemistry.
   Medical physics.
   Radiation.
   Biomedical Engineering and Bioengineering.
   Nanotechnology and Microengineering.
   Biomaterials.
   Molecular Medicine.
   Medical Biochemistry.
   Medical and Radiation Physics.
Анотація: This brief highlights recent research advances in the area of nano-therapeutics. Nanotechnology holds immense potential for application in a wide range of biological and engineering applications such as molecular sensors for disease diagnosis, therapeutic agents for the treatment of diseases, a vehicle for delivering therapeutics and imaging agents for theranostic applications, both in-vitro and in-vivo. The brief is grouped into the following sections namely, A) Discrete Nanosystems ; B) Anisotropic Nanoparticles; C) Nano-films/coated/layered and D) Nano-composites.
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Дод.точки доступу:
Nair, Baiju G.; Sai Krishna, Katla.; Kalagara, Sudhakar.; Narayan, Mahesh.; Noveron, Juan C.; Joddar, Binata.; Tasnim, Nishat. \.\
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20.

    Glucosinolates [Electronic resource] / ed.: Mérillon, Jean-Michel., Ramawat, Kishan Gopal. - 1st ed. 2017. - [S. l. : s. n.]. - 83 illus., 49 illus. in color. eReference. - ISBN 9783319254623
    Зміст:

Part I Occurrence: Glucosinolates: an Overview -- Glucosinolates: Novel Sources and Biological Potential -- Glucosinolates: a Brief overview over their Chemistry and Biological Activities -- Health-Promoting Compounds of Broccoli -- Genetic analysis of Glucosinolate Variability in Broccoli -- Glucosinolates in the Endemic Plants of the Tribe Alysseae (Brassicaceae) Wild-Growing in Croatia -- Part II (Bio)Synthesis: Costs of Glucosinolates in Brassica Rapa -- The Significance of Glucosinolates for Sulfur Storage in Brassicaceae Seedlings -- The Influence of Environment and Process Parameters on Glucosinolate-Myrosinase System from Brassica -- Control of Glucosinolates in Plants by Environmental Factors (Light) -- Part III Bioactivity: Glucosinolates and Plant Defence -- Glucosinolates and Leaf-Chewing Herbivores -- Insect Attraction versus Plant Defense -- The role of Glucosinolates in Resistance against Molluscan Herbivores -- Glucosinolates Interactions with Herbivores and their Natural Enemies -- Transport of Defense Compounds: Glucosinolates -- Control of Postharvest Disease by Glucosinolates -- Turning the 'Mustard Oil Bomb' into A 'Cyanide Bomb': Aromatic Glucosinolate Metabolism in A Specialist Insect Herbivore -- Glucosinolates and their Nematicidal Activity -- Glucosinolate and Isothiocyanate Production in A Plasticulture Production System -- Part IV Food Processing: The Fate of Glucosinolates During Thermal Processing of Vegetables -- Influence of Fermentation on Glucosinolates and Glucobrassicin Degradation Products in Sauerkraut -- Part V Health and Diseases: Glucosinolates in Health and Diseases -- Protection of Humans by Plant Glucosinolates -- Glucosinolates as Antioxidants? -- Glucosinolates and Bone formation -- Glucosinolates as Nutraceuticals -- Glucosinolates and Cholesterol Gallstones -- Glucosinolates and Bioavailibility – Isothiocyanates -- Antimicrobial Activities of Isothiocyanates -- The Role of Glucosinolate-Containing Vegetables in Cancer Prevention and their Promotion in Clinical Practice -- Glucosinolates and Chemopreventive Activity -- Detoxication of Airborne Pollutants by Broccoli Sprouts -- Antibacterial Activity of Glucosinates in Humans -- Anti-inflammatory Activity of Sulforaphane -- Chemopreventive Activity of Sulforaphane and Mechanisms of Action -- Sulforaphane: Antitumor Effects and Induction of Apoptosis -- Sulforaphane and Neuroprotection -- Sulphoraphane and Diabetes -- Sulphoraphane and Atherosclerosis -- Clinical and Molecular Evidence of the Consumption of Broccoli, Glucoraphanin and Sulforaphane in Humans -- Part VI Biotechnology: Metabolic Engineering of Aliphatic Glucosinolates in Hairy Root Cultures -- Biotic Elicitors Effectively increase the Glucosinolates Content -- The Physiological Importance of Glucosinolates on Plant Response to Abiotic Stress -- Sucrose Enhances the Accumulation of anthocyanins and Glucosinolates in Broccoli Sprouts -- Enhancement of Glucosinolate and Sulforaphane Formation of Broccoli Sprouts by Zinc Sulphate via its Stress Effect -- Reactivity and Stability of Glucosinolates and their Breakdown Products in Foods -- Part VII Methods: Extraction and Characterization of Glucosinolates -- Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: Glucosinolates -- Phytochemical Fingerprinting for Simultaneous Identification of Glucosinolates and Phenolics -- Major and Minor Glucosinolates by Mass Spectrometry -- Quantification of Plant Surface Metabolites by Matrix-Assisted Laser Desorption–Ionization Mass Spectrometry Imaging: Glucosinolates on Arabidopsis Thaliana Leaves -- Quantification of Glucosinolates by Reverse-Phase Liquid Chromatography -- Glucosinolates: Extraction and Methods of Analysis from Paper Chromatography to Microchip analysis -- Spectrophotometric Method for Quantification of Total Glucosinolates -- The Use of ‘Omics Technologies in Brassicaceous Vegetables.

Рубрики: Bioorganic chemistry.
   Plant biochemistry.
   Food—Biotechnology.
   Pharmacology.
   Medical biochemistry.
   Plant breeding.
   Bioorganic Chemistry.
   Plant Biochemistry.
   Food Science.
   Pharmacology/Toxicology.
   Medical Biochemistry.
   Plant Breeding/Biotechnology.
Анотація: This is the first comprehensive reference compilation on the substance class of glucosinolates. This handbook introduces the reader to the sulfur-containing glucosinolates (S-glucosides), a class of secondary metabolites of almost all plants of the order Capparales, in particular in the family Brassicaceae (e.g. broccoli and other cabbages), derived from glucose and an amino acid. The book illustrates the natural variety of glucosinolate structures, mainly derived from the precursor amino acid. Chapters describe the resulting rich bioactivity of the glucosides, for example as anti-cancer agents, insecticides, nematicides, fungicides, their potential phytotoxic effects, antimicrobial activity and their possible role in neurodegenerative diseases and human health. Different methods for the extraction, characterization, quantification and processing of the glucosinolates are introduced, and potential applications are discussed. The fate of glucosinolates during food processing is also briefly addressed. This handbook is written by leading experts and structured in different sections addressing the natural occurrence of glucosinolates, their (bio-)synthesis, bioactivity, food processing of glucosinolate-containing vegetables, health and disease-related aspects, biotechnology, and methods applied in glucosinolate-research. It is thus a rich reference source for every reader working in the field, from chemists and biotechnologists, to life scientists, pharmacists and medical scientists.
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Mérillon, Jean-Michel. \ed.\; Ramawat, Kishan Gopal. \ed.\
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