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    JIMD Reports, Volume 32 [Electronic resource] / ed. Morava, Eva. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - VI, 124 p. 30 illus., 15 illus. in color. - ISBN 9783662543856
    Зміст:

Рубрики: Human genetics.
   Metabolic diseases.
   Pediatrics.
   Molecular biology.
   Human Genetics.
   Metabolic Diseases.
   Pediatrics.
   Molecular Medicine.
Анотація: JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
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Дод.точки доступу:
Morava, Eva. \ed.\; Baumgartner, Matthias. \ed.\; Patterson, Marc. \ed.\; Rahman, Shamima. \ed.\; Zschocke, Johannes. \ed.\; Peters, Verena. \ed.\
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    Non-coding RNAs in the Vasculature [Electronic resource] / ed.: Thum, Thomas., Dimmeler, Stefanie. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 101 p. 11 illus. - ISBN 9783319529455
    Зміст:

Рубрики: Biomedical engineering.
   Cardiovascular system.
   Human genetics.
   Cardiology.
   Molecular biology.
   Biomedical Engineering/Biotechnology.
   Cardiovascular Biology.
   Human Genetics.
   Cardiology.
   Molecular Medicine.
Анотація: This book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology.
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Thum, Thomas. \ed.\; Dimmeler, Stefanie. \ed.\
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    Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders [Electronic resource] / ed. Wong, Lee-Jun C. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 364 p. 23 illus., 17 illus. in color. - ISBN 9783319564180
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Рубрики: Microbial genetics.
   Microbial genomics.
   Human genetics.
   Biostatistics.
   Microbial Genetics and Genomics.
   Human Genetics.
   Biostatistics.
Анотація: Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application.
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Wong, Lee-Jun C. \ed.\
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    Sigma Proteins: Evolution of the Concept of Sigma Receptors [Electronic resource] / ed.: Kim, Felix J., Pasternak, Gavril W. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 330 p. 64 illus., 32 illus. in color. - ISBN 9783319658537
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Рубрики: Neurosciences.
   Human physiology.
   Human genetics.
   Cancer research.
   Pharmaceutical technology.
   Neurosciences.
   Human Physiology.
   Human Genetics.
   Cancer Research.
   Pharmaceutical Sciences/Technology.
Анотація: Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of “sigma receptors” to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives.
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Kim, Felix J. \ed.\; Pasternak, Gavril W. \ed.\
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    Parental Responsibility in the Context of Neuroscience and Genetics [Electronic resource] / ed.: Hens, Kristien., Cutas, Daniela., Horstkötter, Dorothee. - 1st ed. 2017. - [S. l. : s. n.]. - XVIII, 246 p. 3 illus. - ISBN 9783319428345
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Introduction -- Chapter 1: Children, neuroscience and genetics: state of the art; Prof. Dr. Frans Feron, Department of Social Medicine, Maastricht University -- Chapter 2: Pathology or condition, an exploration; Prof. Dr. Anna Bosman, Professor in Educational Science, Radboud University Nijmegen -- Chapter 3: Raising self-controlled children; Dr. Dorothee Horstkötter, Assistant Professor in the department of Health, Ethics & Society, Maastricht University -- Chapter 4: The lack of an obligation to select the best child: Silencing the principle of procreative beneficence; Dr. Peter Herissone-Kelly, Senior Lecturer in Philosophy, School of Education and Social Sciences, University of Central Lancashire -- Chapter 5: Genetic Manipulation, Assisted Reproductive Technologies and the Principle of Procreative Beneficence; Dr. Francisco Güell Pelayo, Humanities Faculty, Department of Philosophy, Universidad de Navarra -- Chapter 6: Epigenetics, neurological difference and maternal responsibility; Dr. Kristien Hens, Postdoctoral Researcher, Department of Health, Ethics & Society, Maastricht University -- Chapter 7: What (if any) are parents' responsibilities to preserve children's fertility?; Dr. Daniela Cutas, Associate Professor, Department of Historical, philosophical and religious studies, Umeå Universitet -- Chapter 8: Prenatal child protection? Pressure and coercion in prenatal care for addicted pregnant women; Dr. Wybo Dondorp, Assistant Professor, Department of Health, Ethics & Society, Maastricht University -- Chapter 9: The Ethics of Trinucleotide Repeat Expansion Disorders: Perfecting a Genetic Line to Prevent Mental Illness in Future Generations; Jennifer Chevinsky, B.S., University of Pennsylvania -- Chapter 10: Caregivers’ Responsibilities and Children’s Neurological Differences in Yoruba Culture: Any Ethical Justification?; Fayemi, Ademola Kazeem, Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven -- Chapter 11: Parental responsibility in the context of prenatal diagnosis. Views and attitudes of Belgian healthcare professionals and families; Sylvia Hübel, Adelheid Rigo, PhD, Hans Van Crombrugge, PhD, Kathleen Emmery, Higher Institute for Family Sciences, Brussels.

Рубрики: Ethics.
   Human genetics.
   Maternal and child health services.
   Neurosciences.
   Pediatrics.
   Ethics.
   Human Genetics.
   Maternal and Child Health.
   Neurosciences.
   Pediatrics.
Анотація: Should parents aim to make their children as normal as possible to increase their chances to “fit in”? Are neurological and mental health conditions a part of children’s identity and if so, should parents aim to remove or treat these? Should they aim to instill self-control in their children? Should prospective parents take steps to insure that, of all the children they could have, they choose the ones with the best likely start in life? This volume explores all of these questions and more. Against the background of recent findings and expected advances in neuroscience and genetics, the extent and limits of parental responsibility are increasingly unclear. Awareness of the effects of parental choices on children’s wellbeing, as well as evolving norms about the moral status of children, have further increased expectations from (prospective) parents to take up and act on their changing responsibilities. The contributors discuss conceptual issues such as the meaning and sources of moral responsibility, normality, treatment, and identity. They also explore more practical issues such as how responsibility for children is practiced in Yoruba culture in Nigeria or how parents and health professionals in Belgium perceive the dilemmas generated by prenatal diagnosis.
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Hens, Kristien. \ed.\; Cutas, Daniela. \ed.\; Horstkötter, Dorothee. \ed.\
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    Precision Medicine, CRISPR, and Genome Engineering [Electronic resource] : moving from Association to Biology and Therapeutics / / ed. Tsang, Stephen H. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 178 p. 19 illus., 15 illus. in color. - ISBN 9783319639048
    Зміст:

Рубрики: Regenerative medicine.
   Tissue engineering.
   Stem cells.
   Ophthalmology.
   Human genetics.
   Agriculture.
   Regenerative Medicine/Tissue Engineering.
   Stem Cells.
   Ophthalmology.
   Human Genetics.
   Agriculture.
Анотація: This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians. .
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Tsang, Stephen H. \ed.\
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    Stroke Genetics [Electronic resource] / ed.: Sharma, Pankaj., Meschia, James F. - 2nd ed. 2017. - [S. l. : s. n.]. - XII, 431 p. 39 illus., 26 illus. in color. - ISBN 9783319562100
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Рубрики: Neurology .
   Internal medicine.
   Human genetics.
   Neurology.
   Internal Medicine.
   Human Genetics.
Анотація: This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.
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Sharma, Pankaj. \ed.\; Meschia, James F. \ed.\
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    Human Retrotransposons in Health and Disease [Electronic resource] / ed. Cristofari, Gael. - 1st ed. 2017. - [S. l. : s. n.]. - X, 330 p. 34 illus., 28 illus. in color. - ISBN 9783319483443
    Зміст:

Рубрики: Human genetics.
   Microbial genetics.
   Microbial genomics.
   Stem cells.
   Human Genetics.
   Microbial Genetics and Genomics.
   Stem Cells.
Анотація: This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.
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Cristofari, Gael. \ed.\
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    Gene-Environment Transactions in Developmental Psychopathology [Electronic resource] : the Role in Intervention Research / / ed.: Tolan, Patrick H., Leventhal, Bennett L. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 301 p. 27 illus., 16 illus. in color. - ISBN 9783319492278
    Зміст:

Рубрики: Developmental psychology.
   Psychiatry.
   Human genetics.
   Developmental Psychology.
   Psychiatry.
   Human Genetics.
Анотація: This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.
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Tolan, Patrick H. \ed.\; Leventhal, Bennett L. \ed.\
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10.

    Yu, Han.
    Communicating Genetics [Electronic resource] : visualizations and Representations / / Han. Yu ; . - 1st ed. 2017. - [S. l. : s. n.]. - XI, 271 p. 73 illus. - ISBN 9781137587794
    Зміст:

Рубрики: Technology—Sociological aspects.
   Life sciences.
   Human genetics.
   Science education.
   Science and Technology Studies.
   Life Sciences, general.
   Human Genetics.
   Science Education.
Анотація: This book examines the visual representations used in the popular communication of genetics. Drawing upon public science communication theories, information design theories, and social semiotics, the book offers both in-depth analyses and high-level synthesis of how genetics is visualized for the U.S. public from the early 20th century to the present. Individual chapters focus on six visual genres: photographs, micrographs, illustrations, genetic code images, quantitative graphs, and molecular structure images. Han Yu challenges readers to consider the significance of these images we often take for granted, including their historical contexts, scientific backstories, information richness, stylistic choices, economic motivations, and social implications. In doing so, the book reveals the complex cognitive, affective, and social-cultural factors that both shape and are shaped by these images. The book will be particularly useful to scholars of public science communication and visual communication, practitioners of science communication, and scientists from a range of related life science disciplines. .
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Yu, Han. \.\
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11.

    JIMD Reports, Volume 33 [Electronic resource] / ed. Morava, Eva. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - VI, 110 p. 26 illus. - ISBN 9783662550120
    Зміст:

12.

    Decoding Neural Circuit Structure and Function [Electronic resource] : cellular Dissection Using Genetic Model Organisms / / ed.: Çelik, Arzu., Wernet, Mathias F. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 518 p. 92 illus., 81 illus. in color. - ISBN 9783319573632
Рубрики: Neurosciences.
   Human genetics.
   Cell biology.
   Neurosciences.
   Human Genetics.
   Cell Biology.
Анотація: This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.
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Çelik, Arzu. \ed.\; Wernet, Mathias F. \ed.\
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13.

    Languages and Genes in Northwestern China and Adjacent Regions [Electronic resource] / ed.: Xu, Dan., Li, Hui. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 156 p. 46 illus., 43 illus. in color. - ISBN 9789811041693
    Зміст:

Рубрики: Historical linguistics.
   Languages.
   Language and languages.
   Human genetics.
   Physical anthropology.
   Historical Linguistics.
   Asian Languages.
   Human Genetics.
   Biological and Physical Anthropology.
Анотація: This book presents an investigation of language contact, focusing on Northwestern China. It breaks down the barrier between human sciences and natural sciences in order to reconsider the diversity of languages on the basis of the latest research findings from genetics, linguistics, and other domains, offering valuable insights into when and how the divergence of languages and genes began and language and gene admixture and replacement occurred. The book focuses on language evolution between the border of Gansu and Qinghai Province in China, but the research doesn’t neglect the area beyond China’s northern borders. Manchu, a dying language belonging to the Tungusic group, is also studied to enhance our understanding of language replacement. This work is the result of a four-year collaboration between teams of geneticists and linguists in France and China.
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Xu, Dan. \ed.\; Li, Hui. \ed.\
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14.

    Dupuytren Disease and Related Diseases - The Cutting Edge [Electronic resource] / ed. Werker, Paul M. N. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XVII, 450 p. 170 illus., 150 illus. in color. - ISBN 9783319321998
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Рубрики: Orthopedics.
   Radiotherapy.
   Minimally invasive surgery.
   Plastic surgery.
   Human genetics.
   Surgical Orthopedics.
   Radiotherapy.
   Minimally Invasive Surgery.
   Plastic Surgery.
   Human Genetics.
Анотація: In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed. Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.
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Werker, Paul M. N. \ed.\; Dias, Joseph. \ed.\; Eaton, Charles. \ed.\; Reichert, Bert. \ed.\; Wach, Wolfgang. \ed.\
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15.

    Inherited Metabolic Diseases [Electronic resource] : a Clinical Approach / / ed.: Hoffmann, Georg F., Zschocke, Johannes., Nyhan, William L. - 2nd ed. 2017. - [S. l. : s. n.]. - XVII, 605 p. 80 illus., 34 illus. in color. - ISBN 9783662494103
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Рубрики: Pediatrics.
   Internal medicine.
   General practice (Medicine).
   Neurology .
   Pathology.
   Human genetics.
   Pediatrics.
   Internal Medicine.
   General Practice / Family Medicine.
   Neurology.
   Pathology.
   Human Genetics.
Анотація: This book focuses on clinical presentations that may be caused by inherited metabolic diseases. Its symptom- and system-based approach will help clinicians with and without detailed knowledge of human biochemistry in all specialties to reach a correct diagnosis and institute the optimal treatment program. The book summarizes the central elements of inherited metabolic diseases and describes clearly how to carry out an efficient yet complete diagnostic work-up, thereby guiding the clinician from the presenting symptoms and signs through to effective initial management. After an introduction to the different disorders, the book explains when to consider an inborn metabolic error and which initial tests to order. Core aspects such as structured communication, guidelines, transition, pregnancy, maternal care and how to respond to various medical emergencies are covered. Therapeutic concepts such as dietary treatment are delineated and practical advice provided on the quite different treatment approaches required for individual diseases. An extensive section structured according to organ systems outlines the correct approach in the context of specific symptoms and signs. The value of each of the potential investigations is explained, with precise advice on the interpretation of results. The inclusion of algorithms, tables, lists, and charts facilitates rapid decision making and information retrieval, and the appendices include a helpful guide to differential diagnosis based on clinical and biochemical phenotypes. This new updated edition of Inherited Metabolic Diseases will be an invaluable aid for the busy clinician and an excellent quick reference for metabolic and genetic specialists.
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Hoffmann, Georg F. \ed.\; Zschocke, Johannes. \ed.\; Nyhan, William L. \ed.\
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16.

    Mitochondrial DNA and Diseases [Electronic resource] / ed.: Sun, Hongzhi., Wang, Xiangdong. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 230 p. 89 illus., 62 illus. in color. - ISBN 9789811066740
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Рубрики: Cell biology.
   Human genetics.
   Cell Biology.
   Human Genetics.
Анотація: The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.
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Sun, Hongzhi. \ed.\; Wang, Xiangdong. \ed.\
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17.

    DeKosky, Brandon.
    Decoding the Antibody Repertoire [Electronic resource] : high Throughput Sequencing of Multiple Transcripts from Single B Cells / / Brandon. DeKosky ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXVIII, 87 p. 34 illus. - ISBN 9783319585185
    Зміст:

Рубрики: Antibodies.
   Genetic engineering.
   Human genetics.
   Cell biology.
   Biochemistry.
   Antibodies.
   Genetic Engineering.
   Human Genetics.
   Cell Biology.
   Biochemistry, general.
Анотація: This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.
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DeKosky, Brandon. \.\
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18.

    Epigenetics of Infectious Diseases [Electronic resource] / ed.: Doerfler, Walter., Casadesús, Josep. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 277 p. 22 illus., 14 illus. in color. - ISBN 9783319550213
    Зміст:

Рубрики: Human genetics.
   Virology.
   Cancer research.
   Parasitology.
   Medical microbiology.
   Human Genetics.
   Virology.
   Cancer Research.
   Parasitology.
   Medical Microbiology.
Анотація: The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.
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Дод.точки доступу:
Doerfler, Walter. \ed.\; Casadesús, Josep. \ed.\
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19.

    Topics in Biomedical Gerontology [Electronic resource] / ed.: Rath, Pramod C., Sharma, Ramesh., Prasad, S. - 1st ed. 2017. - [S. l. : s. n.]. - XXI, 355 p. 77 illus. - ISBN 9789811021558
    Зміст:

1. Identification of serum sirtuins as novel non-invasive protein markers for frailty -- 2.Age-related morphological changes in the human pancreas -- 3.Changing population of neurons and glia in the human cochlear nucleus during aging -- 4.Age-related changes in the expression level of insulin-like growth factor-1 and its related signaling pathway in mice -- 5.Differential expression of arginase I and its regulation by dexamethasone in the liver of mice as a function of age -- 6.Molecular and cellular basis of memory enhancing effects ofBacopa monnieri extract on diabetes mellitus induced memory impairment in mice -- 7.Brain aging and oxidative pathology -- 8.Antiepileptic potential of dehydroepiendrosterone (DHEA) -- 9.Curcumin attenuates memory impairment by modulating the expression of CamKIIα during aging -- 10.Dietary restriction, an intervention for healthy aging -- 11.Study of anti-ageing property of moringaoleifera leaves in fish brain -- 12.Alterations in the structure and function of the chromatin during aging -- 13.Postnatal exposure of PBDE-209 impairs spatial memory in young mice:Relation of glutamate and oxidant-antioxidant homeostasis in the frontal cortex and hippocampus -- 14.Differential expression of long intergenic noncoding RNA (lincRNA) in the rat brain during aging -- 15.Dietary restriction up-regulates expression and activity of cardiac and skeletal muscle inorganic pyrophosphatase in mice as a function of age -- 16.Age-related changes in rat kidney antioxidant enzymes and oxidative stress parameters with special reference to catalase promoter methylation pattern -- 17.Recovery of age-related memory loss: hopes and challenges -- 18.Electrophysiological ageing of the brain : Ageing-related impairments in neuronal and cognitive functions -- 19.Role of autophagy in life-extension using Dictyostelium discoideum as a model system -- 20.SIRT-1: An emerging target for age-related neurodegenerative diseases -- 21.Neuroinflammation and the aging brain -- 22.Expression and regulation of Pax6 in brain of aging mice -- 23.Basic tenets of Ayurvedic Gerontology -- 24.Potential use of Ashwagandha (Withania somnifera) for alleviation of old age-associated problems.

Рубрики: Geriatrics.
   Regenerative medicine.
   Tissue engineering.
   Geriatric nursing.
   Human genetics.
   Metabolism.
   Molecular biology.
   Geriatrics/Gerontology.
   Regenerative Medicine/Tissue Engineering.
   Geriatric Care.
   Human Genetics.
   Metabolomics.
   Molecular Medicine.
Анотація: This book presents a collection of articles on various aspects of current research on aging. These include model systems, cellular, biochemical and molecular aspects of experimental aging research, as well as selected intervention studies on age-related diseases. Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity. Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Are there medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age. Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.
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Дод.точки доступу:
Rath, Pramod C. \ed.\; Sharma, Ramesh. \ed.\; Prasad, S. \ed.\
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20.

    JIMD Reports, Volume 35 [Electronic resource] / ed. Morava, Eva. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - VI, 117 p. 20 illus., 10 illus. in color. - ISBN 9783662558331
    Зміст:

Cerebrotendinous Xanthomatosis Presenting with Infantile Spasms and Intellectual Disability -- Hyperammonemia as a Presenting Feature in Two Siblings with FBXL4 Variants -- Intracranial Hypertension in Cystinosis Is a Challenge: Experience in a Children’s Hospital -- Severe Respiratory Acidosis in Status Epilepticus as a Possible Etiology of Sudden Death in Lesch–Nyhan Disease: A Case Report and Review of the Literature -- Vitamin B12 Administration by Subcutaneous Catheter Device in a Cobalamin A (cblA) Patient -- Expansion of the Phenotypic Spectrum of Propionic Acidemia with Isolated Elevated Propionylcarnitine -- Previously Unreported Biallelic Mutation in DNAJC19:Are Sensorineural Hearing Loss and Basal Ganglia Lesions Additional Features of Dilated Cardiomyopathy and Ataxia (DCMA) Syndrome? -- Lysosomal Storage Disorders in Nonimmune Hydrops Fetalis (NIHF): An Indian Experience -- The Risk of Fatty Acid Oxidation Disorders and Organic Acidemias in Children with Normal Newborn Screening -- Clinical and Mutational Characterizations of Ten Indian Patients with Beta-Ketothiolase Deficiency -- Atypical Presentation and Treatment Response in a Child with Familial Hypercholesterolemia Having a Novel LDLR Mutation -- Development of a Tandem Mass Spectrometry Method for Rapid Measurement of Medium- and Very-Long-Chain Acyl-CoA Dehydrogenase Activity in Fibroblasts -- Analysis of Melanin-like Pigment Synthesized from Homogentisic Acid, with or without Tyrosine, and Its Implications in Alkaptonuria -- Bone Health in Classic Galactosemia: Systematic Review and Meta-Analysis -- Cognitive Development in a Young Child with Mucolipidosis Type IV: A Case Report -- White Matter Microstructure and Subcortical Gray Matter Structure Volumes in Aspartylglucosaminuria; a 5-Year Follow-up Brain MRI Study of an Adolescent with Aspartylglucosaminuria and His Healthy Twin Brother -- Erratum to: White Matter Microstructure and Subcortical Gray Matter Structure Volumes in Aspartylglucosaminuria; a 5-Year Follow-up Brain MRI Study of an Adolescent with Aspartylglucosaminuria and His Healthy Twin Brother.

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