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Загальна кількість знайдених документів : 8
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1.


   
    RUNX Proteins in Development and Cancer [Electronic resource] / ed. Groner, Yoram. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XX, 515 p. 98 illus., 92 illus. in color. - ISBN 9789811032332
    Зміст:
Рубрики: Medical genetics.
   Oncology  .
   Proteins .
   Gene Function.
   Oncology.
   Protein Science.
Анотація: This volume provides the reader with an overview of the diverse functions of the RUNX family of genes. As highlighted in the introduction and several of the 29 chapters, humans and other mammals have three RUNX genes that are known to play specific roles in blood, bone and neuronal development. However, their evolutionary history has recently been traced back to unicellular organisms and their involvement in many well-known signaling pathways (Wnt, TGFb, Notch, Hippo) is indicative of a more general function in cell biology. Their documented roles in cell fate decisions include control of proliferation, differentiation, survival, senescence and autophagy. The pleiotropic effects of RUNX in development are mirrored in cancer, where RUNX genes can function as oncogenes that collaborate strongly with Myc family oncogenes or as tumour suppressor genes. In the latter role, they display hallmarks of both ‘gatekeepers’ that modulate p53 responses and ‘caretakers’ that protect the genome from DNA damage. Several chapters focus on the importance of these genes in leukemia research, where RUNX1 and CBFB are frequently affected by chromosomal translocations that generate fusion oncoproteins, while recent studies suggest wider roles for RUNX modulation in solid cancers. Moreover, RUNX genes are intimately involved in the development and regulation of the immune system, while emerging evidence suggests a role in innate immunity to infectious agents, including HIV. At the biochemical level, the RUNX family can serve as activators or repressors of transcription and as stable mediators of epigenetic memory through mitosis. Not surprisingly, RUNX activity is controlled at multiple levels, this includes miRNAs and a plethora of post-translational modifications. Several chapters highlight the interplay between the three mammalian RUNX genes, where cross-talk and partial functional redundancies are evident. Finally, structural analysis of the RUNX/CBFB interaction has led to the development of small molecule inhibitors that provide exciting new tools to decipher the roles of RUNX in development and as targets for therapy. This volume provides a compendium and reference source that will be of broad interest to cancer researchers, developmental biologists and immunologists.
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Дод.точки доступу:
Groner, Yoram. \ed.\; Ito, Yoshiaki. \ed.\; Liu, Paul. \ed.\; Neil, James C. \ed.\; Speck, Nancy A. \ed.\; van Wijnen, Andre. \ed.\
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2.


    Wyandt, Herman E.
    Human Chromosome Variation: Heteromorphism, Polymorphism and Pathogenesis [Electronic resource] / Herman E. Wyandt, Wilson, Golder N., Tonk, Vijay S. ; . - 2nd ed. 2017. - [S. l. : s. n.]. - XX, 490 p. 87 illus., 29 illus. in color. - ISBN 9789811030352
    Зміст:
Рубрики: Medical genetics.
   General practice (Medicine).
   Gene Function.
   General Practice / Family Medicine.
Анотація: This new edition now titled “Human Chromosome Variation: Heteromorphism, Polymorphism and Pathogenesis” provides the reader with an up-to-date overview of microarrays, fragile sites, copy number variations and whole genome sequencing. Greatly expanding the discussion of microarray analysis in the previous edition of the book, are new chapters on microarray and genomic analysis, plus comprehensive tables on the subtle microdeletions and microduplications that are found on each chromosome, including 235 recurring copy number variants that are associated with well-established or emerging chromosomal syndromes. The current edition features concise information on cytogenetic methods and applications, extending these discussions to DNA analysis and genome sequencing. Sections on euchromatin, heterochromatin, FISH pattern, fragile site, copy number, and DNA sequence variation are integrated with actual clinical examples from cytogenetic laboratories and from clinical practice. The principles that allow for the distinction between benign chromosome / DNA variation and pathogenic heteromorphisms / polymorphisms are discussed and include references to the latest organizational guidelines and genomic or population databases. The two previous incarnations of this book: the ‘Atlas of Human Chromosome Heteromorphism’, and ‘Human Chromosome Variation: Heteromorphism and Polymorphism’ have been standard reference works in most cytogenetic laboratories, used by laboratory directors and clinicians all around the world. While widely used sections from the previous edition on cytogenetic technologies and heteromorphisms are retained intact the present volume adds extensive material on copy number variations (polymorphisms detected by microarray analysis), fragile sites in disease and cancer, and practical views on interpreting emerging technologies, including whole exome sequencing. This book should be of interest to clinicians, technicians and students who are or will be exposed to DNA and/or chromosome analysis and the data derived from these continuously developing techniques. This fully updated book volume will bring the reader up to speed on the latest technologies, their applications, benefits and drawbacks and as such, is a must read for anyone with an interest in DNA and chromosome analysis and the distinction between benign variation and pathogenic mistakes.
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Wilson, Golder N.; Tonk, Vijay S.; Wyandt, Herman E. \.\
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3.


   
    Metabolomics: From Fundamentals to Clinical Applications [Electronic resource] / ed. Sussulini, Alessandra. - 1st ed. 2017. - [S. l. : s. n.]. - X, 350 p. 56 illus., 54 illus. in color. - ISBN 9783319476568
    Зміст:
Рубрики: Metabolism.
   Gene therapy.
   Medical genetics.
   Metabolomics.
   Gene Therapy.
   Gene Function.
Анотація: This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
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Sussulini, Alessandra. \ed.\
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4.


   
    Personalised Medicine [Electronic resource] : lessons from Neurodegeneration to Cancer / / ed. El-Khamisy, Sherif. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 260 p. 98 illus., 52 illus. in color. - ISBN 9783319607337
    Зміст:
Рубрики: Cancer research.
   Medical genetics.
   Molecular biology.
   Cancer Research.
   Gene Function.
   Molecular Medicine.
Анотація: The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.
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El-Khamisy, Sherif. \ed.\
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5.


   
    Introduction to Biomolecular Structure and Biophysics [Electronic resource] : basics of Biophysics / / ed. Misra, Gauri. - 1st ed. 2017. - [S. l. : s. n.]. - XVII, 274 p. 133 illus., 78 illus. in color. - ISBN 9789811049682
    Зміст:
Рубрики: Biomedical engineering.
   Biophysics.
   Biological physics.
   Nucleic acids.
   Proteins .
   Medical genetics.
   Biomedical Engineering/Biotechnology.
   Biological and Medical Physics, Biophysics.
   Nucleic Acid Chemistry.
   Protein Science.
   Gene Function.
   Protein-Ligand Interactions.
Анотація: This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small Angle X-ray Scattering (SAXS) and cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques used to study important biomolecules.
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Misra, Gauri. \ed.\
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6.


   
    Neuroepigenomics in Aging and Disease [Electronic resource] / ed. Delgado-Morales, Raul. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 525 p. 41 illus., 39 illus. in color. - ISBN 9783319538891
    Зміст:
Рубрики: Proteomics.
   Gene expression.
   Medical genetics.
   Proteomics.
   Gene Expression.
   Gene Function.
Анотація: Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.
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Delgado-Morales, Raul. \ed.\
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7.


   
    Long Non Coding RNA Biology [Electronic resource] / ed. Rao, M.R.S. - 1st ed. 2017. - [S. l. : s. n.]. - XVI, 323 p. 34 illus., 32 illus. in color. - ISBN 9789811052033
    Зміст:
Рубрики: Gene expression.
   Developmental biology.
   Medical genetics.
   Nucleic acids.
   Gene Expression.
   Developmental Biology.
   Gene Function.
   Nucleic Acid Chemistry.
Анотація: This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
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Rao, M.R.S. \ed.\
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8.


   
    The Biophysics of Cell Membranes [Electronic resource] : biological Consequences / / ed.: Epand, Richard M., Ruysschaert, Jean-Marie. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 219 p. 49 illus., 32 illus. in color. - ISBN 9789811062445
    Зміст:
Рубрики: Cell membranes .
   Biophysics.
   Biological physics.
   Bioorganic chemistry.
   Medical genetics.
   Membrane Biology.
   Biological and Medical Physics, Biophysics.
   Bioorganic Chemistry.
   Gene Function.
Анотація: This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic the prevailing asymmetry in biological membranes by forming asymmetrical membranes made of monolayers with different compositions. One of the chapters illustrates how physical parameters, like curvature and elasticity, can affect and modulate the interactions between lipids and proteins. This volume also describes the sensitivity of certain ion channels to mechanical forces and it presents an analysis of how cell shape is determined by both the cytoskeleton and the lipid domains in the membrane. The last chapter provides evidence that liposomes can be used as a minimal cellular model to reconstitute processes related to the origin of life. Each topic covered in this volume is presented by leading experts in the field who are able to present clear, authoritative and up-to-date reviews. The novelty of the methods proposed and their potential for a deeper molecular description of membrane functioning are particularly relevant experts in the areas of biochemistry, biophysics and cell biology, while also presenting clear and thorough introductions, making the material suitable for students in these fields as well.
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Дод.точки доступу:
Epand, Richard M. \ed.\; Ruysschaert, Jean-Marie. \ed.\
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