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Загальна кількість знайдених документів : 11
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1.


   
    Cell Division Machinery and Disease [Electronic resource] / ed.: Gotta, Monica., Meraldi, Patrick. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 235 p. 33 illus., 32 illus. in color. - ISBN 9783319571270
    Зміст:
Рубрики: Cell cycle.
   Cell physiology.
   Cancer research.
   Cell Cycle Analysis.
   Cell Physiology.
   Cancer Research.
Анотація: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
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Gotta, Monica. \ed.\; Meraldi, Patrick. \ed.\
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2.


    Rashid, Summya.
    Cancer and Chemoprevention: An Overview [Electronic resource] / Summya. Rashid ; . - 1st ed. 2017. - [S. l. : s. n.]. - XVII, 173 p. 19 illus., 13 illus. in color. - ISBN 9789811025792
    Зміст:
Рубрики: Cancer research.
   Apoptosis.
   Gene expression.
   Cell cycle.
   Immunology.
   Cancer Research.
   Apoptosis.
   Gene Expression.
   Cell Cycle Analysis.
   Immunology.
Анотація: This book focuses on the most recent, relevant, comprehensive and significant advances in cancer and chemo prevention. It broadly discusses cancer, its hallmarks and classification, molecular mechanisms of outbreak, contributing factors, role of oxidative stress, inflammatory mediators and evading apoptosis, which leads to the progression of disease. Though modern medicine has left us with no option to treat this deadly disease due to drawbacks associated with conventional treatment – like its non-targeted nature, drug resistance, varied organ toxicities and unaffordability – chemoprevention offers a viable therapeutic window. Given chemoprevention’s importance in the present scenario, the book highlights various chemo preventive strategies currently used in the management of cancer; a selection of novel chemo preventive agents used at clinics and in the pre-clinical stage; hurdles to effective chemoprevention; future prospects and the road ahead. It offers a valuable guide for all graduate students and researchers seeking information on cancer and chemoprevention in general, irrespective of the specific type/pathways involved in its onset.
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Rashid, Summya. \.\
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3.


   
    Molecular Basis for Mitochondrial Signaling [Electronic resource] / ed. Rostovtseva, Tatiana K. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 386 p. 61 illus., 54 illus. in color. - ISBN 9783319555393
    Зміст:
Рубрики: Biophysics.
   Biological physics.
   Cell cycle.
   Apoptosis.
   Biological and Medical Physics, Biophysics.
   Cell Cycle Analysis.
   Apoptosis.
Анотація: This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.
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Rostovtseva, Tatiana K. \ed.\
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4.


   
    Molecules, Systems and Signaling in Liver Injury [Electronic resource] / ed.: Ding, Wen-Xing., Yin, Xiao-Ming. - 1st ed. 2017. - [S. l. : s. n.]. - XV, 290 p. 25 illus., 20 illus. in color. - ISBN 9783319581064
Рубрики: Cell cycle.
   Apoptosis.
   Cell physiology.
   Hepatology.
   Cell membranes .
   Cell Cycle Analysis.
   Apoptosis.
   Cell Physiology.
   Hepatology.
   Membrane Biology.
Анотація: This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecules, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.
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Ding, Wen-Xing. \ed.\; Yin, Xiao-Ming. \ed.\
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5.


   
    Centromeres and Kinetochores [Electronic resource] : discovering the Molecular Mechanisms Underlying Chromosome Inheritance / / ed. Black, Ben E. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 554 p. 101 illus., 98 illus. in color. - ISBN 9783319585925
    Зміст:
Рубрики: Cell cycle.
   Cell physiology.
   Human genetics.
   Cell Cycle Analysis.
   Cell Physiology.
   Human Genetics.
Анотація: This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.
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Black, Ben E. \ed.\
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6.


   
    Cellular Injury in Liver Diseases [Electronic resource] / ed.: Ding, Wen-Xing., Yin, Xiao-Ming. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 263 p. 26 illus., 22 illus. in color. - ISBN 9783319537740
    Зміст:
Рубрики: Cell cycle.
   Apoptosis.
   Cell physiology.
   Hepatology.
   Cell membranes .
   Cell Cycle Analysis.
   Apoptosis.
   Cell Physiology.
   Hepatology.
   Membrane Biology.
Анотація: This comprehensive volume describes drug and virus-mediated hepatocyte injury, alcohol, lipid and bile acid-induced hepatocyte injury in addition to ischemia-reperfusion-mediated liver injury. The chapter authors who discuss these topics are leading experts on cell death in liver diseases. The authors link these different types of liver injury to the commonly associated liver inflammation, fibrosis and tumorigenesis. Other topics explored include the various forms of cell death and cell survival pathways that have been identified in the liver, such as apoptosis, necroptosis, pryoptosis and autophagy. This book, along with its companion volume, Molecules, Systems and Signaling in Hepatic Cell Death, provides a thorough and comprehensive discussion on the topic of cell death and liver disease. Cellular Injury in Liver Diseases is an essential addition to the Cell Death in Biology and Diseases series and will appeal to scientists, clinicians and those doing research for drug discovery. .
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Ding, Wen-Xing. \ed.\; Yin, Xiao-Ming. \ed.\
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7.


   
    Signaling-Mediated Control of Cell Division [Electronic resource] : from Oogenesis to Oocyte-to-Embryo Development / / ed. Arur, Swathi. - 1st ed. 2017. - [S. l. : s. n.]. - X, 292 p. 37 illus., 34 illus. in color. - ISBN 9783319448206
    Зміст:
Рубрики: Embryology.
   Cell cycle.
   Stem cells.
   Gene expression.
   Cell physiology.
   Embryology.
   Cell Cycle Analysis.
   Stem Cells.
   Gene Expression.
   Cell Physiology.
Анотація: This volume covers the current knowledge base on the role of signaling and environmental pathways that control the normal development of germline stem cells, meiotic progression of oocytes, events of oocyte maturation and fertilization, and the birth of an embryo. Germ cells are uniquely poised to sustain life across generations through the fusion of oocyte and sperm. Because of the central importance of germ cells to life, much work has been dedicated to obtaining a clear understanding of the molecular and signaling events that control their formation and maintenance. Germ cells are set aside from somatic cells in the embryo and go through specialized meiotic cell cycles as the animal matures. These cell cycles are interspersed with long periods of arrest. In human females, meiosis I is initiated in the fetus. At birth, oocytes are arrested in meiosis I; after puberty, every month an oocyte initiates meiosis II – ovulation. Upon sperm availability these cells are fertilized, generate an embryo, and the cycle-of-life continues. During meiotic I progression and arrest, the fitness of oocytes and their progeny are likely influenced by environmental cues and signaling pathways. A lot of recent work has focused on understanding the mechanisms that regulate oocyte fitness and quality in humans and vertebrates. Much of our understanding on the events of meiosis I and germline stem cell populations comes from work in invertebrates, wherein the germline stem cells produce oocytes continuously through adult development. In both inverbrates and vertebrates nutritional and signaling pathways control the regulation of stem cells in such a manner so as to couple production of gametes with the nutritional availability. Additionally, mature oocytes arrest both in meiosis I and meiosis II, and signaling and nutritional pathways have been shown to regulate their formation, and maintenance, such that despite long periods of arrest, the oocyte quality is assured and errors in chromosome segregation and varied cytoplasmic events are minimal.
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Arur, Swathi. \ed.\
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8.


   
    Asymmetric Cell Division in Development, Differentiation and Cancer [Electronic resource] / ed.: Tassan, Jean-Pierre., Kubiak, Jacek Z. - 1st ed. 2017. - [S. l. : s. n.]. - VI, 421 p. 96 illus., 81 illus. in color. - ISBN 9783319531502
    Зміст:
Рубрики: Cell cycle.
   Embryology.
   Stem cells.
   Cancer research.
   Cell Cycle Analysis.
   Embryology.
   Stem Cells.
   Cancer Research.
Анотація: This book provides readers with an overview of the frequent occurrence of asymmetric cell division. Employing a broad range of examples, it highlights how this mode of cell division constitutes the basis of multicellular organism development and how its misregulation can lead to cancer. To underline such developmental correlations, readers will for example gain insights into stem cell fate and tumor growth. In turn, subsequent chapters include descriptions of asymmetric cell division from unicellular organisms to humans in both physiological and pathological conditions. The book also illustrates the importance of this process for evolution and our need to understand the background mechanisms, offering a valuable guide not only for students in the field of developmental biology but also for experienced researchers from neighboring fields.
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Tassan, Jean-Pierre. \ed.\; Kubiak, Jacek Z. \ed.\
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9.


   
    Cyanidioschyzon merolae [Electronic resource] : a New Model Eukaryote for Cell and Organelle Biology / / ed. Kuroiwa, Tsuneyoshi. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 365 p. 111 illus., 82 illus. in color. - ISBN 9789811061011
    Зміст:
Рубрики: Microbiology.
   Microbial genetics.
   Microbial genomics.
   Plant physiology.
   Plant genetics.
   Cell cycle.
   Eukaryotic Microbiology.
   Microbial Genetics and Genomics.
   Plant Physiology.
   Applied Microbiology.
   Plant Genetics and Genomics.
   Cell Cycle Analysis.
Анотація: This comprehensive book highlights the importance of Cyanidioschyzon merolae (C. merolae), an ultrasmall unicellular red alga, as a model eukaryote organism. The chapters introduce recent studies on C. merolae, from culture, synchronization and isolation methods of nucleic acids, proteins and organelles for molecular biological and cytological analyses, as well as its application in genetic engineering of environmental-stress-tolerant crops and oil production. In addition to discussing recent advances based on the complete genome information and molecular biological techniques such as genetic modifications and bioinformatics, the book includes visualization aids demonstrating that both classical and recent imaging techniques of fluorescent and electron microscopy can be applied to analyses of C. merolae. This publication offers a definitive resource for both beginners and professionals studying C. merolae, particularly in the field of molecular biology, evolutionary biology, morphology, biochemistry and cell biology, as well as those interested in its applications in medical sciences and agriculture.
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Kuroiwa, Tsuneyoshi. \ed.\; Miyagishima, Shinya. \ed.\; Matsunaga, Sachihiro. \ed.\; Sato, Naoki. \ed.\; Nozaki, Hisayoshi. \ed.\; Tanaka, Kan. \ed.\; Misumi, Osami. \ed.\
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10.


   
    Oocytes [Electronic resource] : maternal Information and Functions / / ed. Kloc, Malgorzata. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 510 p. 86 illus., 77 illus. in color. - ISBN 9783319608556
    Зміст:
Рубрики: Embryology.
   Gene expression.
   Cell cycle.
   Cell physiology.
   Reproductive medicine.
   Embryology.
   Gene Expression.
   Cell Cycle Analysis.
   Cell Physiology.
   Reproductive Medicine.
Анотація: This book combines the most recent knowledge on the maternal, i.e. oocyte/egg-specific, molecules and processes. The volume covers the most recent advances in a plethora of subjects such as: maternal transfer of immunity, localized RNAs functions and mechanisms of RNA localization, transcriptional repression of maternal messages, maternal inheritance and maternal role of CRISPR/Cas9-based genome editing, chromatin remodeling and epigenetic modifications, maternal function of nucleosomes, maternal mitochondria and energy supply, role of bacterial symbionts and their maternal transmission, acquisition of oocyte polarity and evolution of maternal effect genes, germ plasm and oosome origin and functions, mechanisms of oocyte activation and soma germ cells communication.  Currently, no other book on the market combines such a comprehensive list of subjects in one volume. Moreover, the information provided is a cross-section through oocytes from various invertebrate a nd vertebrate species, which is another unique feature of this book. The readers, therefore, get a completely new and invaluable perspective on all covered subjects. .
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11.


   
    TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease [Electronic resource] / ed.: Telerman, Adam., Amson, Robert. - 1st ed. 2017. - [S. l. : s. n.]. - X, 309 p. 51 illus., 36 illus. in color. - ISBN 9783319675916
    Зміст:
Рубрики: Cancer research.
   Proteins .
   Stem cells.
   Cell cycle.
   Apoptosis.
   Cancer Research.
   Protein Structure.
   Stem Cells.
   Cell Cycle Analysis.
   Apoptosis.
Анотація: This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis. In turn, the book’s final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.
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Telerman, Adam. \ed.\; Amson, Robert. \ed.\
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