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    Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy [Electronic resource] / ed. Kalinski, Pawel. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 264 p. 47 illus., 43 illus. in color. - ISBN 9783319675770
    Зміст:

Рубрики: Cancer research.
   Oncology  .
   Immunology.
   Molecular biology.
   Cancer Research.
   Oncology.
   Immunology.
   Molecular Medicine.
Анотація: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
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    Mechanisms of Molecular Carcinogenesis – Volume 2 [Electronic resource] / ed. Haybaeck, Johannes. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 374 p. 47 illus., 42 illus. in color. - ISBN 9783319536613
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Рубрики: Cancer research.
   Oncology  .
   Molecular biology.
   Cytokines.
   Growth factors.
   Gene expression.
   Cancer Research.
   Oncology.
   Molecular Medicine.
   Cytokines and Growth Factors.
   Gene Expression.
Анотація: Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.
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    Organelle Contact Sites [Electronic resource] : from Molecular Mechanism to Disease / / ed.: Tagaya, Mitsuo., Simmen, Thomas. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 257 p. 43 illus., 42 illus. in color. - ISBN 9789811045677
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Рубрики: Cell biology.
   Biochemistry.
   Molecular biology.
   Human physiology.
   Cancer research.
   Immunology.
   Cell Biology.
   Biochemistry, general.
   Molecular Medicine.
   Human Physiology.
   Cancer Research.
   Immunology.
Анотація: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
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Tagaya, Mitsuo. \ed.\; Simmen, Thomas. \ed.\
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    Immune Metabolism in Health and Tumor [Electronic resource] / ed.: Li, Bin., Pan, Fan. - 1st ed. 2017. - [S. l. : s. n.]. - V, 223 p. 24 illus., 23 illus. in color. - ISBN 9789402411706
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Рубрики: Immunology.
   Posttranslational modification.
   Medical microbiology.
   Cancer research.
   Immunology.
   Posttranslational Modification.
   Medical Microbiology.
   Cancer Research.
Анотація: This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.
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Li, Bin. \ed.\; Pan, Fan. \ed.\
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    Ribatti, Domenico.
    Inflammation and Angiogenesis [Electronic resource] / Domenico. Ribatti ; . - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 111 p. 36 illus., 24 illus. in color. - ISBN 9783319684482
Рубрики: Cancer research.
   Cancer Research.
Анотація: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter. .
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Ribatti, Domenico. \.\
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    Sigma Proteins: Evolution of the Concept of Sigma Receptors [Electronic resource] / ed.: Kim, Felix J., Pasternak, Gavril W. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 330 p. 64 illus., 32 illus. in color. - ISBN 9783319658537
    Зміст:

Рубрики: Neurosciences.
   Human physiology.
   Human genetics.
   Cancer research.
   Pharmaceutical technology.
   Neurosciences.
   Human Physiology.
   Human Genetics.
   Cancer Research.
   Pharmaceutical Sciences/Technology.
Анотація: Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of “sigma receptors” to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives.
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Kim, Felix J. \ed.\; Pasternak, Gavril W. \ed.\
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    Single Cell Analysis [Electronic resource] : contemporary Research and Clinical Applications / / ed.: Robinson, J. Paul., Cossarizza, Andrea. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 266 p. 84 illus., 70 illus. in color. - ISBN 9789811044991
    Зміст:

Рубрики: Biomedical engineering.
   Immunology.
   Biophysics.
   Biological physics.
   Cancer research.
   Cell biology.
   Biomedical Engineering and Bioengineering.
   Immunology.
   Biological and Medical Physics, Biophysics.
   Cancer Research.
   Cell Biology.
Анотація: This book highlights the current state of the art in single cell analysis, an area that involves many fields of science – from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems.
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    Essential and Non-essential Metals [Electronic resource] : carcinogenesis, Prevention and Cancer Therapeutics / / ed.: Mudipalli, Anuradha., Zelikoff, Judith T. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 228 p. 74 illus., 65 illus. in color. - ISBN 9783319554488
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Рубрики: Cancer research.
   Molecular biology.
   Cancer Research.
   Molecular Medicine.
Анотація: This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
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Mudipalli, Anuradha. \ed.\; Zelikoff, Judith T. \ed.\
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    Cell Division Machinery and Disease [Electronic resource] / ed.: Gotta, Monica., Meraldi, Patrick. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 235 p. 33 illus., 32 illus. in color. - ISBN 9783319571270
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Рубрики: Cell cycle.
   Cell physiology.
   Cancer research.
   Cell Cycle Analysis.
   Cell Physiology.
   Cancer Research.
Анотація: This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
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Gotta, Monica. \ed.\; Meraldi, Patrick. \ed.\
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10.

    Biotechnology and Production of Anti-Cancer Compounds [Electronic resource] / ed. Malik, Sonia. - 1st ed. 2017. - [S. l. : s. n.]. - XV, 328 p. 53 illus., 36 illus. in color. - ISBN 9783319538808
    Зміст:

Рубрики: Plant breeding.
   Cell culture.
   Natural resources.
   Pharmacology.
   Cancer research.
   Plant Breeding/Biotechnology.
   Cell Culture.
   Natural Resources.
   Pharmacology/Toxicology.
   Cancer Research.
Анотація: This book discusses cancers and the resurgence of public interest in plant-based and herbal drugs. It also describes ways of obtaining anti-cancer drugs from plants and improving their production using biotechnological techniques. It presents methods such as cell culture, shoot and root culture, hairy root culture, purification of plant raw materials, genetic engineering, optimization of culture conditions as well as metabolic engineering with examples of successes like taxol, shikonin, ingenol mebutate and podophylotoxin. In addition, it describes the applications and limitations of large-scale production of anti-cancer compounds using biotechnological means. Lastly, it discusses future economical and eco-friendly strategies for obtaining anti-cancer compounds using biotechnology.
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11.

    Extracellular Matrix in Tumor Biology [Electronic resource] / ed.: Brekken, Rolf A., Stupack, Dwayne. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 115 p. 23 illus., 22 illus. in color. - ISBN 9783319609072
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Рубрики: Cancer research.
   Immunology.
   Molecular biology.
   Oncology  .
   Proteins .
   Cell biology.
   Cancer Research.
   Immunology.
   Molecular Medicine.
   Oncology.
   Receptors.
   Cell Biology.
Анотація: This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.
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Brekken, Rolf A. \ed.\; Stupack, Dwayne. \ed.\
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12.

    Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins [Electronic resource] / ed.: Grawunder, Ulf., Barth, Stefan. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 181 p. 57 illus., 39 illus. in color. - ISBN 9783319468778
    Зміст:

Рубрики: Pharmacology.
   Antibodies.
   Pharmacotherapy.
   Cancer research.
   Oncology  .
   Pharmacology/Toxicology.
   Antibodies.
   Pharmacotherapy.
   Cancer Research.
   Oncology.
Анотація: This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
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Grawunder, Ulf. \ed.\; Barth, Stefan. \ed.\
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13.

    Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity [Electronic resource] / ed. Yoshimura, Akihiko. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 267 p. - ISBN 9783319689296
    Зміст:

Рубрики: Immunology.
   Cancer research.
   Cell biology.
   Immunology.
   Cancer Research.
   Cell Biology.
Анотація: This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
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Yoshimura, Akihiko. \ed.\
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14.

    Drug Resistance in Bacteria, Fungi, Malaria, and Cancer [Electronic resource] / ed.: Arora, Gunjan., Sajid, Andaleeb., Kalia, Vipin Chandra. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 630 p. 64 illus., 49 illus. in color. - ISBN 9783319486833
Рубрики: Drug resistance.
   Cell biology.
   Cancer research.
   Bacteriology.
   Drug Resistance.
   Cell Biology.
   Cancer Research.
   Bacteriology.
Анотація: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer. Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.
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Arora, Gunjan. \ed.\; Sajid, Andaleeb. \ed.\; Kalia, Vipin Chandra. \ed.\
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15.

    EMR/ESR/EPR Spectroscopy for Characterization of Nanomaterials [Electronic resource] / ed. Shukla, Ashutosh Kumar. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 179 p. 96 illus., 35 illus. in color. - ISBN 9788132236559
    Зміст:

Рубрики: Nanotechnology.
   Materials science.
   Mechanics.
   Mechanics, Applied.
   Spectroscopy.
   Cancer research.
   Nanotechnology.
   Characterization and Evaluation of Materials.
   Solid Mechanics.
   Spectroscopy/Spectrometry.
   Cancer Research.
Анотація: The subject matter of this book is the application of EMR/ESR/EPR spectroscopy for characterization of nanomaterials. Initial chapters deal with nanomaterials and their classification. Characterization of metallic nanoparticles, metal oxide nanoparticles and rare earth impurity doped nanoparticles from the (ESR) spectrum parameters are covered in the chapters that follow. A special feature of the book is EMR/ESR/EPR spectroscopic characterization of nanoparticles which are important due to their bactericidal and anticancerous properties. Strength of continuous wave (CW) is explained with the help of suitable examples. The book focuses on applications and data interpretation avoiding extensive use of mathematics so that it also caters to the need of young scientists in the life science disciplines. The book includes a comparison with other spectroscopic characterization methods so as to give an integrated approach to the reader. It will prove useful to biomedical scientists and engineers, chemists, and materials engineers in student, researcher, and practitioner positions.
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Shukla, Ashutosh Kumar. \ed.\
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16.

    Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173 [Electronic resource] / ed. Nilius, Bernd. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - V, 88 p. 10 illus., 8 illus. in color. - ISBN 9783319613673
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Рубрики: Cancer research.
   Neurosciences.
   Pharmacology.
   Psychiatry.
   Cancer Research.
   Neurosciences.
   Pharmacology/Toxicology.
   Psychiatry.
Анотація: M. T. Rahman, N. Haque, N. H. A. Kassim: Origin, Function and Fate of Metallothionein in Human Blood L. Ribeiro, P. Bastos, T. Gomes: .Catechol-O-methyltransferase (COMT): An Update on its Role in Cancer, Neurological and Cardiovascular Disease. B.M. Fonseca, N. Teixeira, G. Correia-da-Silva: Cannabinoids as Modulators of Cell Death: Clinical Applications and Future Directions. .
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Nilius, Bernd. \ed.\; de Tombe, Pieter. \ed.\; Gudermann, Thomas. \ed.\; Jahn, Reinhard. \ed.\; Lill, Roland. \ed.\; Petersen, Ole H. \ed.\
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17.

    Management of Lymphomas: A Case-Based Approach [Electronic resource] / ed.: Zain, Jasmine., Kwak, Larry W. - 1st ed. 2017. - [S. l. : s. n.]. - XXII, 204 p. 36 illus., 26 illus. in color. - ISBN 9783319268279
    Зміст:

Рубрики: Hematology.
   Oncology  .
   Cancer research.
   Pharmacotherapy.
   Hematology.
   Oncology.
   Cancer Research.
   Pharmacotherapy.
Анотація: This book will provide an overview of how to manage patients with lymphoma in the format of a series of engaging case studies. Lymphomas are cancers that originate in the lymphatic system. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. These lymphomas comprise various subtypes with prognosis and treatment depending on the stage and type of the cancer. Lymphoma is a major global health problem; non-Hodgkin lymphoma in particular is the tenth most common type of cancer worldwide. In response to this there have been a number of significant advances in the available treatment options for lymphoma with new breakthrough drugs being approved or registered for approval. In light of this, this case study book will be an extremely timely guide for all hematologists, oncologists, and healthcare professionals wishing to keep up-to-date with these recent developments. The format of this book is also particularly appealing as it offer readers a practical approach to the clinical management of patients with these conditions as suggested by leading physicians from the City of Hope National Medical Center in California, USA in an era of vast therapeutic development.
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Zain, Jasmine. \ed.\; Kwak, Larry W. \ed.\
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18.

    Rajagopal, Senthilkumar.
    Calcium Signaling: From Physiology to Diseases [Electronic resource] / Senthilkumar. Rajagopal, Ponnusamy, Murugavel. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XVI, 91 p. 19 illus., 17 illus. in color. - ISBN 9789811051609
    Зміст:

Рубрики: Cell biology.
   Neurology .
   Cardiology.
   Pediatrics.
   Cancer research.
   Cell Biology.
   Neurology.
   Cardiology.
   Pediatrics.
   Cancer Research.
Анотація: This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.
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Ponnusamy, Murugavel.; Rajagopal, Senthilkumar. \.\
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19.

    Translational Research in Breast Cancer [Electronic resource] : biomarker Diagnosis, Targeted Therapies and Approaches to Precision Medicine / / ed.: Song, Erwei., Hu, Hai. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 418 p. 15 illus. in color. - ISBN 9789811060205
    Зміст:

Рубрики: Cancer research.
   Cell biology.
   Cancer Research.
   Cell Biology.
Анотація: This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research. .
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Song, Erwei. \ed.\; Hu, Hai. \ed.\
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20.

    Mitra, Kunal.
    Short Pulse Laser Systems for Biomedical Applications [Electronic resource] / Kunal. Mitra, Miller, Stephanie. ; . - 1st ed. 2017. - [S. l. : s. n.]. - VII, 49 p. 26 illus., 9 illus. in color. - ISBN 9783319542539
    Зміст:

Рубрики: Biomedical engineering.
   Lasers.
   Photonics.
   Cancer research.
   Nanotechnology.
   Biomedical Engineering and Bioengineering.
   Biomedical Engineering/Biotechnology.
   Optics, Lasers, Photonics, Optical Devices.
   Cancer Research.
   Nanotechnology and Microengineering.
Анотація: This book presents practical information on the clinical applications of short pulse laser systems and the techniques for optimizing these applications in a manner that will be relevant to a broad audience, including engineering and medical students as well as researchers, clinicians, and technicians. Short pulse laser systems are useful for both subsurface tissue imaging and laser induced thermal therapy (LITT), which hold great promise in cancer diagnostics and treatment. Such laser systems may be used alone or in combination with optically active nanoparticles specifically administered to the tissues of interest for enhanced contrast in imaging and precise heating during LITT. Mathematical and computational models of short pulse laser-tissue interactions that consider the transient radiative transport equation coupled with a bio-heat equation considering the initial transients of laser heating were developed to analyze the laser-tissue interaction during imaging and therapy. Experiments were first performed to characterize the tissue optical properties needed to optimize the dose for thermal therapy. Experiments were then performed on animal models to characterize the heat affected zone for LITT. The experimental measurements were also validated using the computational models. .
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Miller, Stephanie.; Mitra, Kunal. \.\
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