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    Advances in Vision Research, Volume I [Electronic resource] : genetic Eye Research in Asia and the Pacific / / ed.: Prakash, Gyan., Iwata, Takeshi. - 1st ed. 2017. - [S. l. : s. n.]. - XV, 523 p. 71 illus., 55 illus. in color. - ISBN 9784431565116
    Зміст:

1. Foundation of Asian Eye Genetics Consortium (AEGC) (Gyan Prakash, Takeshi Iwata) -- 2. Japan consortium for whole exome analysis of hereditary retinal diseases (Takeshi Iwata) -- 3. Whole-genome sequencing in genetic eye diseases in China (Zi-bing Jin) -- 4. Targeted exome sequencing in Japanese patients with Retinitis Pigmentosa (Maho Oishi, Akio Oishi, Nagahisa Yoshimura) -- 5. Genetic Epidemiology of Congenital Cataracts and Autosomal Recessive Retinal Degenerations in Pakistan (Fielding Hejtmancik, Qiwei Wang, Yabin Chen, Sheikh Riazuddin and S. Amer Riazuddin) -- 6. Genetics of Cataract in Asia (Chitra Kannabiran and Vanita) -- 7. Genetic analysis of families with retinal dystrophies (Qingjiong Zhang) -- 8. Whole genome sequencing in patients with Retinitis Pigmentosa (Koji M. Nishiguchi) -- 9. Retinitis pigmentosa in Korean patients (C.K. Yoon, U.C. Park and H.G. Yu) -- 10. Retinitis pigmentosa in Chinese population (Ruifang Sui and Xuan Zou) -- 11. Retinitis Pigmentosa in Japanese Population (Katsuhiro Hosono, Shinsei Minoshima, Yoshihiro Hotta) -- 12. Cone Dysfunction Syndrome in Japanese Population (Takaaki Hayashi) -- 13. Leber Congenital Amaurosis/Early-Onset Retinal Dystrophy in Japanese Population (Kazuki Kuniyoshi and Yoshikazu Shimomura) -- 14. Paradigm of Susceptibility genes in AMD and PCV (Paul N. Baird and Moeen Riaz) -- 15. Genetics and Pathology of Inflammatory Components on AMD (Xiaoxin Li, Lv-Zhen Huang, Peng Zhou and Chi Chao Chan) -- 16. Genome wide association study of age-related eye diseases in Chinese population (Guy L.J. Chen, Shi Song Rong and Calvin C.P. Pang) -- 17. Clinical Genetics of Retinoblastoma: An Asian Perspective (Ashwin Mallipatna and Meghan Marino and Arun Singh) -- 18. Molecular and Clinical Genetics of Retinoblastoma (Jason C.S. Yam, Winnie W. Y. Lau, Wai Kit Chu, L.J. Chen, K. W. Choy, Simon T.C. and Calvin C.P. Pang) -- 19. Current research Perspectives in Understanding Diabetic Retinopathy (A Jayamuruga Pandian, Nagasamy Soumittra, Rajiv Raman, Sarangapani Sripriya) -- 20. Genome-wide association studies of glaucoma (Zachary Dong, Chiea Chuen Khor and Janey L. Wiggs) -- 21. Genetic Complexity of Primary Angle Closure Glaucoma in Asians (Roopam Duvesh, R Venkatesh, S Kavitha, Pradeep Ramulu, SR Krishnadas and P Sundaresan) -- 22. Genotype-phenotype correlation for POAG in the Middle East Khaled Abu-Amero (Saudi Arabia), Alta (A. Kondkar and Ahmed Mousa) -- 23. Corneal Dystrophies in India (Namrata Sharma and Arundhati Sharma) -- 24. Genetics of Corneal Endothelial Dystrophies: An Asian Perspective (Sudha Neelam, Jod Mehta, Eranga Vithana and Vinod Mootha) -- 25. Keratoconus in Asia (Rajiv Mohan, Arkasubhra Ghosh and Rohit Shetty) -- 26. Genetics of Pediatric Eye Diseases and Strabismus in Asia (Zia Chaudhuri and Birgit Lorenz) -- 27. Keratoconus: Globally and in the Middle East; Epidemiology, Genetics and future Research (Ahmed Mousa, Altaf Kondkar and Khaled Abu-Amero) -- 28. Genetics of Myopia (Sushil Kumari Sangwan, Arundhati Sharma, Namrata Sharma, Radhika Tandon) -- 29. Ocular Implications of Gaucher Disease (Mones S. Abu-Asab, Ian Y. L. Yeung, Christopher Ardeljan, Ashley N. Gonzalez, Ellen Sidransky, Chi-Chao Chan) -- 30. Genetic background of Uveitis in Chinese population (Peiziang Yang, Hongsong Yu, Bo Lei and Aize Kijlstra) -- 31. Usher Syndrome in Chinese and Japanese Population (Shi-Ying Li, Linghui Qu, and Xiaohong Meng, and Zheng Qin Yin) -- 32. Homozygosity Mapping for Autosomal Recessive Ocular Diseases (Chandrasekar SatyaPriya, Sundaramoorthy Srilekha, Karthikeyan Sudha, Sarangapani Sripriya, Nagasamy Soumittra) -- 33. Tools of Genetic Eye Research and Need for Clinical Research Collaborations (Vanita Vanita and Umang Mathur) -- 34. Eye Genetics: The Road Ahead to Quality Standards (Sridhar Bammidi, Kaushal Sharma, Rahul Tyagi, Neel Kamal Sharma and Akshay Anand) -- 35. Genetic Counselling in Asia (Viney Gupta and Ken K. Nischal) -- 36. Epigenetic study in Asian Eye Diseases (Lai Wei, Xiao Hu and Xiafeng Wen) -- 37. Unique Asian Patients Population: An Opportunity for Drug Development (Rajkumar Patil, Cheng Ching Yu, Chui Ming Gemmy Cheung and Tien Yin Wong -- 38. A Perspective: How can gene therapeutics help address ophthalmic health issues in Asia? (Paul Kaufman).

Рубрики: Ophthalmology.
   Human genetics.
   Ophthalmology.
   Human Genetics.
Анотація: This book presents the state of the art in genetic eye research in Asia and the Pacific. Though there has been an explosion of information on genetic eye research in western countries, more than sixty percent of the human genes involved in eye diseases in the Asian and Pacific population remain unknown. However, new efforts and a new awareness have sparked important discussions on the subject, and new plans are being implemented to discover the genes responsible for many eye diseases in the population. The book reviews the latest findings; its content ranges from genetic aspects of human migration to DNA sequence analysis, genome-wide association analysis, and disease phenotypes. The efforts of the Asian Eye Genetic Consortium (AEGC) are also discussed. The book’s editors have been instrumental in developing strategies for discovering the new Asian genes involved in many eye diseases. All chapters were written by leading researchers working on Asian eye genetics from the fields of Human Genetics, Ophthalmology, Molecular Biology, Biochemistry, Sensory Sciences, and Clinical Research. Advances in Vision Research, Volume I will prove to be a major resource for all researchers, clinicians, clinical researchers, and allied eye health professionals with an interest in eye diseases among the Asian population.
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Prakash, Gyan. \ed.\; Iwata, Takeshi. \ed.\
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    Guest, Paul C.
    Biomarkers and Mental Illness [Electronic resource] : it’s Not All in the Mind / / Paul C. Guest ; . - 1st ed. 2017. - [S. l. : s. n.]. - XII, 203 p. 61 illus., 51 illus. in color. - ISBN 9783319460888
    Зміст:

Рубрики: Bioinformatics.
   Human genetics.
   Psychiatry.
   Bioinformatics.
   Human Genetics.
   Psychiatry.
Анотація: Employing accessible language throughout, this book covers the history of psychiatric research, the current state-of-the art in psychiatric practice, the physiological systems affected by psychiatric illnesses, the whole-body nature of these diseases and the impact that this aspect has on emerging biomarker discoveries. Further, it provides descriptions of the major specific psychiatric disorders and the special challenges regarding the diagnosis and treatment of each. The book concludes with insights into the latest developments in hand-held biomarker test devices, which can provide diagnostic information in less than 15 minutes in point-of-care settings. This book investigates the emerging use of biomarkers in the study of psychiatric diseases, a topic of considerable importance for a broad range of people including researchers, clinicians, psychiatrists, university students and even those whose lives are affected in some way by a psychiatric illness. The last category is hardly trivial, since a staggering one in three people worldwide show the criteria for at least one psychiatric disorder at some point in their lifetime. .
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    Biomarkers for Endometriosis [Electronic resource] : state of the Art / / ed. D'Hooghe, Thomas. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 267 p. 8 illus., 3 illus. in color. - ISBN 9783319598567
    Зміст:

Рубрики: Reproductive medicine.
   Bioinformatics.
   Human genetics.
   Reproductive Medicine.
   Bioinformatics.
   Human Genetics.
Анотація: This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
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D'Hooghe, Thomas. \ed.\
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    Breast Cancer [Electronic resource] : innovations in Research and Management / / ed. Veronesi, Umberto. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 928 p. 296 illus., 236 illus. in color. - ISBN 9783319488486
    Зміст:

Part I An Integrated view of Breast Cancer Biology -- Fundamental pathways in breast cancer 1: signaling from the membrane -- Fundamental pathways in breast cancer 2: maintenance of genomic stability.-Fundamental pathways in breast cancer 3: estrogen biology -- Fundamental pathways in breast cancer 4: maintenance of epigenomic stability and the role of stem cells -- Breast cancer microenvironment and the metastatic process -- Mouse models of breast cancer -- Human mammary tumor virus proteins in human breast cancer cells -- Part II Epidemiology, Genetics and Prevention -- Epidemiology, life style and environment -- Genetic predisposition -- Chemoprevention -- Surgical prevention -- Part III Pathology: Standard and Molecular Diagnostics -- Premalignant lesions -- Prognostic and predictive role of genetic signatures -- Adding molecular information to immunohistochemistry -- Special types of breast cancer and nonepithelial tumors -- Pathology after neoadjuvant treatments -- Breast cancer genomics -- Pathology report 2015 -- Part IV Imaging -- Radiological screening of breast cancer. Evolution -- Innovation of radiological means for breast cancer -- Nuclear medicine in the clinical management (ROLL, SNB and PET) -- One-step systemic staging for patients with breast cancer -- Imaging after breast surgery -- Integrated breast biopsy for best radiological diagnosis of breast cancer -- Part V Oncological Surgery -- Conservative surgery -- Conservative mastectomies -- Surgical treatment of reappearance of breast cancer -- Management of the axilla -- Management of intraepithelial disease -- Surgery after neoadjuvant therapies -- Surgery of primary tumor in stage IV breast cancers -- Local therapy for breast cancer in malignant lymphoma survivors -- Surgery of metastases -- Part VI Plastic and Reconstructive Surgery -- Oncoplastic surgery -- Delayed breast reconstruction -- Immediate breast reconstruction direct-to-implant -- Breast reconstruction with tissue expanders and definitive implant replacement -- Breast reconstruction with pedicled flaps -- Breast reconstruction with free flaps -- Contralateral breast management -- Fat grafting in breast reconstruction -- Breast reconstruction with biological and nonbiological meshes -- How to manage complications in breast reconstruction -- Part VII Medical Oncology -- Adjuvant systemic therapies by subtypes: guidelines -- Primary systemic therapies: guidelines -- Treatment of advanced disease: guidelines -- Endocrine therapies in the adjuvant and advanced disease settings -- Chemotherapy regimens in the adjuvant and advanced disease settings -- Anti-HER2 therapies in the adjuvant and advanced disease settings -- Systemic therapy with bisphosphonates and anti-RANK-L agents -- Systemic treatment for specific medical situations -- Part VIII Radiotherapy -- Conceptual basis and principles of radiation oncology -- Whole breast radiation following breast-conserving surgery in invasive cancer -- Whole breast radiation following breast-conserving surgery in noninvasive cancer -- Post-mastectomy radiotherapy -- Integration of radiotherapy with systemic therapies -- Partial breast irradiation -- Intraoperative radiotherapy ELIOT -- Radiotherapy for metastatic lesions -- Part IX Special Conditions Requiring Multidisciplinary Approaches -- Emergencies in breast cancer -- Breast cancer during pregnancy -- Fertility issues in patients with newly diagnosed breast cancer -- Sexual functions and breast cancer -- Male breast cancer -- Inflammatory breast cancer -- Treatment of CNS involvement -- Treatment of skeletal disease -- Follow-up of patients with breast cancer -- Part X Investigating New Drugs and Immunological Agents in Breast Cancer -- Targeting immune-checkpoint -- Targeting PIK3CA/AKT/mTOR -- Targeting genome instability and DNA repair -- Targeting CDK4/6 pathway -- Targeting FGFR pathway -- Integrating next generation sequencing data in trial design -- Part XI Investigational and Miscellaneous Approaches -- Lifestyle and breast cancer -- Psychological support -- HIFU and radiofrequency as alternatives to surgery -- Hyperthermia with RT and with systemic therapies -- Electro-chemotherapy -- Circulating miRNA in early diagnosis -- Relevance of stem cells -- Part XII Biostatistics and Bioinformatics -- Subgroup analyses and information from clinical trials on breast cancer -- The methodology of meta analyses and its potential contribution to patient care -- Modern biostatistics for accelerated data acquisition for new drugs -- Bioinformatics for clinical use in breast cancer -- Efficacy endpoints in breast cancer studies.

Рубрики: Oncology  .
   Radiology.
   Surgery.
   Pathology.
   Human genetics.
   Oncology.
   Imaging / Radiology.
   Surgery.
   Pathology.
   Human Genetics.
Анотація: This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
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Veronesi, Umberto. \ed.\; Goldhirsch, Aron. \ed.\; Veronesi, Paolo. \ed.\; Gentilini, Oreste Davide. \ed.\; Leonardi, Maria Cristina. \ed.\
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    Dakubo, Gabriel D.
    Cancer Biomarkers in Body Fluids [Electronic resource] : biomarkers in Circulation / / Gabriel D. Dakubo ; . - 1st ed. 2017. - [S. l. : s. n.]. - XIX, 509 p. 20 illus. in color. - ISBN 9783319483603
Рубрики: Human genetics.
   Oncology  .
   Cancer research.
   Human Genetics.
   Oncology.
   Cancer Research.
Анотація: This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.
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    Centromeres and Kinetochores [Electronic resource] : discovering the Molecular Mechanisms Underlying Chromosome Inheritance / / ed. Black, Ben E. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 554 p. 101 illus., 98 illus. in color. - ISBN 9783319585925
    Зміст:

Рубрики: Cell cycle.
   Cell physiology.
   Human genetics.
   Cell Cycle Analysis.
   Cell Physiology.
   Human Genetics.
Анотація: This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.
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    Yu, Han.
    Communicating Genetics [Electronic resource] : visualizations and Representations / / Han. Yu ; . - 1st ed. 2017. - [S. l. : s. n.]. - XI, 271 p. 73 illus. - ISBN 9781137587794
    Зміст:

Рубрики: Technology—Sociological aspects.
   Life sciences.
   Human genetics.
   Science education.
   Science and Technology Studies.
   Life Sciences, general.
   Human Genetics.
   Science Education.
Анотація: This book examines the visual representations used in the popular communication of genetics. Drawing upon public science communication theories, information design theories, and social semiotics, the book offers both in-depth analyses and high-level synthesis of how genetics is visualized for the U.S. public from the early 20th century to the present. Individual chapters focus on six visual genres: photographs, micrographs, illustrations, genetic code images, quantitative graphs, and molecular structure images. Han Yu challenges readers to consider the significance of these images we often take for granted, including their historical contexts, scientific backstories, information richness, stylistic choices, economic motivations, and social implications. In doing so, the book reveals the complex cognitive, affective, and social-cultural factors that both shape and are shaped by these images. The book will be particularly useful to scholars of public science communication and visual communication, practitioners of science communication, and scientists from a range of related life science disciplines. .
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Yu, Han. \.\
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    Wallace, Rodrick.
    Computational Psychiatry [Electronic resource] : a Systems Biology Approach to the Epigenetics of Mental Disorders / / Rodrick. Wallace ; . - 1st ed. 2017. - [S. l. : s. n.]. - XII, 236 p. 31 illus. - ISBN 9783319539102
    Зміст:

Рубрики: Systems biology.
   Human genetics.
   Psychiatry.
   Systems Biology.
   Human Genetics.
   Psychiatry.
Анотація: This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.
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    Decoding Neural Circuit Structure and Function [Electronic resource] : cellular Dissection Using Genetic Model Organisms / / ed.: Çelik, Arzu., Wernet, Mathias F. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 518 p. 92 illus., 81 illus. in color. - ISBN 9783319573632
Рубрики: Neurosciences.
   Human genetics.
   Cell biology.
   Neurosciences.
   Human Genetics.
   Cell Biology.
Анотація: This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.
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Çelik, Arzu. \ed.\; Wernet, Mathias F. \ed.\
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10.

    DeKosky, Brandon.
    Decoding the Antibody Repertoire [Electronic resource] : high Throughput Sequencing of Multiple Transcripts from Single B Cells / / Brandon. DeKosky ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXVIII, 87 p. 34 illus. - ISBN 9783319585185
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Рубрики: Antibodies.
   Genetic engineering.
   Human genetics.
   Cell biology.
   Biochemistry.
   Antibodies.
   Genetic Engineering.
   Human Genetics.
   Cell Biology.
   Biochemistry, general.
Анотація: This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.
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11.

    Dupuytren Disease and Related Diseases - The Cutting Edge [Electronic resource] / ed. Werker, Paul M. N. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - XVII, 450 p. 170 illus., 150 illus. in color. - ISBN 9783319321998
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Рубрики: Orthopedics.
   Radiotherapy.
   Minimally invasive surgery.
   Plastic surgery.
   Human genetics.
   Surgical Orthopedics.
   Radiotherapy.
   Minimally Invasive Surgery.
   Plastic Surgery.
   Human Genetics.
Анотація: In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed. Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.
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Werker, Paul M. N. \ed.\; Dias, Joseph. \ed.\; Eaton, Charles. \ed.\; Reichert, Bert. \ed.\; Wach, Wolfgang. \ed.\
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12.

    Balistreri, Carmela Rita.
    Endothelial Progenitor Cells [Electronic resource] : a New Real Hope? / / Carmela Rita. Balistreri ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXII, 80 p. 23 illus. - ISBN 9783319551074
Рубрики: Stem cells.
   Human genetics.
   Regenerative medicine.
   Tissue engineering.
   Stem Cells.
   Human Genetics.
   Regenerative Medicine/Tissue Engineering.
Анотація: This book explores the role of endothelial progenitor cells (EPCs) in the context of regenerative medicine (RegMed). In particular, it reveals the value of RegMed as a new TM branch intended to improve the health and quality of life, by restoring, maintaining or enhancing tissue and functions of organs. The book is divided into three chapters, the first of which describes the relevance of translational medicine (TM) as a new research approach to counteract the imposing challengeof age-related diseases. Of the diverse RegMed approaches, particular attention is paid to stem/progenitor cell-based therapies, their benefits and shortcomings, as well as to the description of types of stem and progenitor cells considered for regenerative cell therapies, such as EPCs as emerging candidates for RegMed applications. In turn, the second chapter outlines the clinical relevance of EPCs as both potential predictors, diagnostic and prognostic biomarkers of age-related diseases and therapeutic agents,discussing their advantages, disadvantages, and conflicting data. Chapter three proposes a potential roadmap for revising the findings and creating a clearer picture of valid data, which can provide support for various important aspects, i.e.isolating and characterizing EPCs by establishing standardized criteria for EPC research, identifying appropriate sub-populations for cell therapy, timing, dosing, priming of cells,and defining delivery modes for different applications. The book concludes with an overview of innovative strategies that could improve the efficacy of cell therapy at all levels, including cell priming, bio-nanotechnology, and tissue engineering.
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Balistreri, Carmela Rita. \.\
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13.

    Epigenetics of Infectious Diseases [Electronic resource] / ed.: Doerfler, Walter., Casadesús, Josep. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 277 p. 22 illus., 14 illus. in color. - ISBN 9783319550213
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Рубрики: Human genetics.
   Virology.
   Cancer research.
   Parasitology.
   Medical microbiology.
   Human Genetics.
   Virology.
   Cancer Research.
   Parasitology.
   Medical Microbiology.
Анотація: The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.
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Doerfler, Walter. \ed.\; Casadesús, Josep. \ed.\
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14.

    Evolution of the Human Genome I [Electronic resource] : the Genome and Genes / / ed. Saitou, Naruya. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 305 p. 74 illus., 39 illus. in color. - ISBN 9784431566038
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Рубрики: Evolutionary biology.
   Human genetics.
   Anthropology.
   Evolutionary Biology.
   Human Genetics.
   Anthropology.
Анотація: This book reviews the human genome from an evolutionary perspective. No such book has ever been published before, although there are many books on human genomes. There are two parts in this book: Overview of the Human Genome (Part I) and The Human Genome Viewed through Genes (Part II). In Part I, after a brief review of human evolution and the human genome (by Naruya Saitou), chapters on rubbish or junk DNA (by Dan Graur), GC content heterogeneity (by Satoshi Oota), protein coding and RNA coding genes (by Tadashi Imanishi), duplicated genes (by Takashi Kitano), recombinations (by Montanucci and Bertranpetit), and copy number variations including microsatellites (by Naoko Takezaki) are discussed. Readers can obtain various new insights on the human genome from this part. In Part II, genes in X and Y chromosomes (by Yoko Satta and others), HLA genes (by Timothy A. Jinam), opsin genes (by Shoji Kawamura and Amanda D. Melin), genes related to phenotypic variations (by Ryosuke Kimura), transcription factors (by Mahoko Takahashi and So Nakagawa), diabetes-related genes (by Ituro Inoue), disease genes in general (by Ituro Inoue and Hirofumi Nakaoka), and microbial genomes (by Chaochun Wei) are discussed. The human genome sequences were determined in 2004, and after more than 10 years we are now beginning to understand the human genome from an evolutionary point of view. This book furnishes readers with a good summary of current research in the field.
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Saitou, Naruya. \ed.\
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15.

    Gene-Environment Transactions in Developmental Psychopathology [Electronic resource] : the Role in Intervention Research / / ed.: Tolan, Patrick H., Leventhal, Bennett L. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 301 p. 27 illus., 16 illus. in color. - ISBN 9783319492278
    Зміст:

Рубрики: Developmental psychology.
   Psychiatry.
   Human genetics.
   Developmental Psychology.
   Psychiatry.
   Human Genetics.
Анотація: This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.
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Tolan, Patrick H. \ed.\; Leventhal, Bennett L. \ed.\
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16.

    Genome Analysis and Human Health [Electronic resource] / ed.: Rawal, Leena., Ali, Sher. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 168 p. 19 illus. in color. - ISBN 9789811042980
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Рубрики: Human genetics.
   Molecular biology.
   Cancer research.
   Nucleic acids.
   Biomedical engineering.
   Human Genetics.
   Molecular Medicine.
   Cancer Research.
   Nucleic Acid Chemistry.
   Biomedical Engineering/Biotechnology.
Анотація: This book highlights selected current data and its relevance in the human health care system, offering a fundamental primer on genetics and human health. With the advent of new high-throughput technologies (for the whole genome including exome sequencing), the conventional focus on genetics and individual genes is now shifting toward the analysis of complex genes, gene-gene interactions and the association between genes and environment, including epigenetics. The rapidly changing scientific research landscape, with the ever-growing influx of data on one hand and emergence of newer and more complicated diseases on the other, has created a dilemma for researchers and caregivers, who are still hopeful that advances in genetics and genomics will provide avenues for the understanding, prevention and possible cure of human diseases. The book focuses on the interactions between genes and proteins at both the transcriptome and proteome levels, which in turn affect the human genome and health. Additionally, it covers the domain that must be explored in order to understand the gene-gene and protein-protein interactions that contribute to human health. The book offers a valuable guide for all students and researchers working in the area of molecular genetics and genomics.
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Rawal, Leena. \ed.\; Ali, Sher. \ed.\
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17.

    Genome Editing in Neurosciences [Electronic resource] / ed.: Jaenisch, Rudolf., Zhang, Feng., Gage, Fred. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 123 p. 16 illus. in color. - ISBN 9783319601922
    Зміст:

Рубрики: Human genetics.
   Neurosciences.
   Biomedical engineering.
   Human Genetics.
   Neurosciences.
   Biomedical Engineering/Biotechnology.
Анотація: This book is open access under a CC BY 4.0 license. Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
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Jaenisch, Rudolf. \ed.\; Zhang, Feng. \ed.\; Gage, Fred. \ed.\
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18.

    Kwabi-Addo, Bernard.
    Health Outcomes in a Foreign Land [Electronic resource] : a Role for Epigenomic and Environmental Interaction / / Bernard. Kwabi-Addo ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXVI, 324 p. 16 illus. - ISBN 9783319558653
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Рубрики: Epidemiology.
   Social structure.
   Social inequality.
   Human genetics.
   Ethnicity.
   Epidemiology.
   Social Structure, Social Inequality.
   Human Genetics.
   Ethnicity Studies.
Анотація: This stimulating volume uses multiple lenses to analyze the complex causes of health disparities affecting minorities, in particular African Americans, and explains how this knowledge can be used to reduce their destructive effects. Pinpointing genetic, non-genetic, and epigenetic factors underlying health conditions common to the population—including heart disease, hypertension, diabetes, and cancer—the author traces intricate links among these factors in the current environmental and social context. The section on non-genetic factors in health disparities, such as social determinants and health behaviors, adds depth to the ongoing discourse on public health and health policy objectives. And the chapters on gene/environment interactions outline the vast potential for developing new multidisciplinary frontiers in shrinking health inequities and personalizing care. Included in the coverage: The African diaspora and disease-specific disparities The genetic basis to health disparities The role of epigenetics Economic factors and health Psychological issues and how they affect disparities Gene-environment interactions in health disparities Race, a biological or social concept Compelling and accessible, Health Outcomes in a Foreign Land will challenge and inspire medical students, epidemiologists, public health professionals, biomedical research scientists, and social scientists to go farther in their work. A wider audience would include policymakers, government officials, nurses, physicians, lawyers, economists, community outreach investigators, and interested general readers. .
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Kwabi-Addo, Bernard. \.\
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19.

    History of Human Genetics [Electronic resource] : aspects of Its Development and Global Perspectives / / ed.: Petermann, Heike I., Harper, Peter S., Doetz, Susanne. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 576 p. 36 illus., 29 illus. in color. - ISBN 9783319517834
    Зміст:

Introduction -- Part I: Workshops on the History of Human Genetics -- The International Workshops on Genetics, Medicine and History: An Overview, 2003–2015 -- Part II: Beginning of Human Genetics -- Ancestral Concepts of Human Genetics and Molecular Medicine in Epicurean Philosophy -- Bateson and the Doctors: The Introduction of Mendelian Genetics to the British Medical Community 1900–1910 -- Part III: Genetics and Medicine -- Pedigrees and Prejudices: Pre-WWII Inherited Disease Classification at the US Eugenics Record Office -- Aldred Scott Warthin’s Family ‘G’: The American Plot Against Cancer and Heredity (1895–1940) -- Genetic Discrimination in the Doctoring of Cancer and Alcoholism -- The Genomization of Biology: Counterbalancing Radical Reductionism -- A Brief History of Uncertainty in Medical Genetics and Genomics -- Part IV: Countries -- “Nature’s Laboratories of Human Genetics”: Alpine Isolates, Hereditary Diseases and Medical Genetic Fieldwork, 1920–1970 -- Some Thoughts on Genetics and Politics. The Historical Misrepresentation of Scandinavian Eugenics and Sterilization -- Changing the Point of View: The History of Human Genetics as an Applied Science in the Federal Republic of Germany, 1945–1975 -- Herbert Bach (1926–1996): One of the Pioneers of Human Genetics in East Germany (GDR) -- Concise History of Prenatal Diagnostic Service in Russia -- Foundation of the International Federation of Human Genetic Societies: The Catalyst -- Part V: Gene Mapping -- The First Human Genetic Map 1936 -- Glasgow Contributions to Human Gene Mapping -- Human Gene Mapping: The Mass Media Iconography of the Human Genome Project in the Most Popular Greek Newspapers -- Part VI: Narrated History -- National Human Genome Research Institute History of Genomics Oral History Program: An Example of “Triangulation” -- Narrating Genes: How Patients with Chronic Inflammatory Bowel Diseases Interpret an Emerging Disease Aetiology and How We Can Make Sense Out of It by Developing a Historically and Sociologically Informed Framework -- Part VII: Genetic Counselling -- The Establishment of Genetic Counselling in Sweden: 1940–1980 -- Counselling, Risk and Prevention in Human Genetic Early Diagnosis in the Federal Republic of Germany -- “The Happiness of the Individual Is of Primary Importance”:Genetic Counselling in the GDR -- Remarks on the History of Genetic Counselling in Czechoslovakia, 1945–1990 -- The Establishment of Human Genetic Counselling in Austria in the 1970s in Between the Establishment of Human Genetics and the Eugenic Indication of Abortion -- Genetic Counselling in Belgium: The Centre for Human Genetics at the University of Leuven, 1960–1990 -- Genetic Counselling for Mediterranean Anaemia in Post-war Greece -- Karyotyping and the Emergence of Genetic Counselling in Mexico in the 1960s -- Newborn Screening on the Cusp of Genetic Screening: From Solidarity in Public Health to Personal Counselling -- Feminist Criticism of Genetic Counselling in the Second Half of the Twentieth Century -- The Evolving Concept of Non-directiveness in Genetic Counselling -- A Comparative and Social History of Genetic Counselling?.

Рубрики: Human genetics.
   Molecular biology.
   Human Genetics.
   Molecular Medicine.
Анотація: Written by 30 authors from all over the world, this book provides a unique overview of exciting discoveries and surprising developments in human genetics over the last 50 years. The individual contributions, based on seven international workshops on the history of human genetics, cover a diverse range of topics, including the early years of the discipline, gene mapping and diagnostics. Further, they discuss the status quo of human genetics in different countries and highlight the value of genetic counseling as an important subfield of medical genetics.
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Petermann, Heike I. \ed.\; Harper, Peter S. \ed.\; Doetz, Susanne. \ed.\
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20.

    Behrend, Claudia.
    Human Chromosome Atlas [Electronic resource] : introduction to diagnostics of structural aberrations / / Claudia. Behrend, Karimzad Hagh, Javad., Mehdipour, Parvin., Schwanitz, Gesa. ; . - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 207 p. 97 illus. - ISBN 9783319540993
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Рубрики: Human genetics.
   Cell biology.
   Human Genetics.
   Cell Biology.
Анотація: This atlas presents the results of cases of structural chromosome aberrations based on the currently available methods of analysis for different types of abnormality. It particularly focuses on which spectrum should be chosen when combining the different techniques to achieve the best method of diagnosis in individual cases, for example direct preparation of cells and mitoses, short or long-time cell culture, fluorescence in situ hybridization (FISH), analysis of interphases, microarray or DNA sequencing. Generally it has to be taken into account, that the development of new and improved investigation methods is forthcoming. Thus, by improvement of diagnostic possibilities new fields of investigation arise, and special groups of patients with cytogenetic analyses can be re-analysed under new research questions.
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Karimzad Hagh, Javad.; Mehdipour, Parvin.; Schwanitz, Gesa.; Behrend, Claudia. \.\
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