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1.


   
    Asbestos and Mesothelioma [Electronic resource] / ed. Testa, Joseph R. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 407 p. 65 illus., 43 illus. in color. - ISBN 9783319535609
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.
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2.


   
    Advances in Biology and Treatment of Glioblastoma [Electronic resource] / ed. Somasundaram, Kumaravel. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 272 p. 24 illus. in color. - ISBN 9783319568201
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: This volume covers the most important areas of glioblastoma – surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists. .
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Somasundaram, Kumaravel. \ed.\
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3.


   
    Immunotherapy [Electronic resource] / ed.: Naing, Aung., Hajjar, Joud. - 1st ed. 2017. - [S. l. : s. n.]. - V, 184 p. 17 illus. - ISBN 9783319531564
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: In the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response. Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents. As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer.
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Naing, Aung. \ed.\; Hajjar, Joud. \ed.\
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4.


   
    Cancer Vaccines [Electronic resource] / ed.: Savelyeva, Natalia., Ottensmeier, Christian. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 210 p. - ISBN 9783319239101
    Зміст:
Рубрики: Cancer research.
   Immunology.
   Vaccines.
   Cancer Research.
   Immunology.
   Vaccine.
Анотація: This volume focuses on the laboratory and clinical experience with targeting viral onco-antigens, while also reviewing the approaches to targeting self-cancer antigens in cancers of non-viral origin, where self-tolerance has been a challenge. It emphasizes the importance of selecting the right vaccine platform to induce a successful immune response against cancer antigens. In addition, the volume discusses the advances made with genetic vaccines, including recent advances with DNA vaccines and the rapid transition of mRNA vaccines from the laboratory to bedside. The new avenues opening up for cancer immunotherapy underline the importance of combinational approaches using cancer vaccines with costimulatory antibodies, which may dramatically improve cancer treatment. This book is intended for all translational researchers and clinicians who aspire to develop novel vaccination approaches for cancer patients with unmet clinical needs.
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Savelyeva, Natalia. \ed.\; Ottensmeier, Christian. \ed.\
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5.


   
    Resistance to Targeted Therapies in Breast Cancer [Electronic resource] / ed. Prosperi, Jenifer R. - 1st ed. 2017. - [S. l. : s. n.]. - XV, 184 p. 12 illus. - ISBN 9783319701424
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). We have also provided an overview of standard of care as an introduction into the importance of targeted therapy. It is our hope that this volume gives an insight into the landscape of breast cancer treatment, the challenges of targeted therapy, and a glimpse into the future of breast cancer therapy.  .
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Prosperi, Jenifer R. \ed.\
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6.


   
    Biomarkers of the Tumor Microenvironment [Electronic resource] : basic Studies and Practical Applications / / ed.: Akslen, Lars A., Watnick, Randolph S. - 1st ed. 2017. - [S. l. : s. n.]. - XVII, 534 p. 52 illus., 51 illus. in color. - ISBN 9783319391472
    Зміст:
Рубрики: Pathology.
   Cancer research.
   Pathology.
   Cancer Research.
Анотація: This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
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Akslen, Lars A. \ed.\; Watnick, Randolph S. \ed.\
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7.


    Penteado Schmidt, Schmidt, Carolina Witchmichen.
    Drug Therapy and Interactions in Pediatric Oncology [Electronic resource] : a Pocket Guide / / Schmidt, Carolina Witchmichen. Penteado Schmidt, de Menezes, Fabiana Gatti. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXI, 212 p. 15 illus. in color. - ISBN 9783319388724
    Зміст:
Рубрики: Pediatrics.
   Oncology  .
   Hematology.
   Pharmacy.
   Cancer research.
   Pediatrics.
   Oncology.
   Hematology.
   Drug Safety and Pharmacovigilance.
   Cancer Research.
   Pharmacy.
Анотація: There are few publications about drug interactions in chemotherapy and even less about pediatric oncology treatment. For this reason, the present book is intended to offer guidelines about drug interactions for physicians, pharmacists and the other healthcare professionals involved in the chemotherapy of pediatric patients. In this book the reader will have access to a primary introduction for the major diseases in pediatric oncology, followed by the major therapeutic protocols. Following that, the most important drug interactions in pediatric oncology treatment are presented and discussed in detail. Finally, important topics such as Drug-Food Interactions are addressed. Drug Therapy and Interactions in Pediatric Oncology focuses in great detail on the drug interactions in Pediatric Oncohematology and will be an indispensable resource in daily practice for a wide range of health providers. .
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de Menezes, Fabiana Gatti.; Penteado Schmidt, Carolina Witchmichen. \.\
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8.


   
    Molecular Genetics of Endometrial Carcinoma [Electronic resource] / ed. Hedrick Ellenson, Lora. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 281 p. 32 illus., 31 illus. in color. - ISBN 9783319431390
    Зміст:
Рубрики: Cancer research.
   Gene expression.
   Pathology.
   Cancer Research.
   Gene Expression.
   Pathology.
Анотація: This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
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Hedrick Ellenson, Lora. \ed.\
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9.


   
    Infectious Agents Associated Cancers: Epidemiology and Molecular Biology [Electronic resource] / ed.: Cai, Qiliang., Yuan, Zhenghong., Lan, Ke. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 271 p. 18 illus. in color. - ISBN 9789811057656
Рубрики: Cancer research.
   Medical microbiology.
   Virology.
   Parasitology.
   Cancer Research.
   Medical Microbiology.
   Virology.
   Parasitology.
Анотація: This book offers a state-of-the-art report on recent discoveries concerning viral, bacterial, and parasite infectious cancers. Cancer is one of the most common causes of death and diseases in human populations, and 15%-25% of human cancers in worldwide are considered to result from chronic infection by pathogens. Most oncology textbooks address genetic mutation, but not infectious agents such as viruses, bacteria and parasites. As such this book stimulates further research in the new area between cancers and chronic infection, and discusses the epidemiology and molecular biology of infectious causes of cancers. It also explores the prevention and treatment of infection-related cancers, and brings pathogenic research to the forefront in the never-ending endeavor to understand how pathogens maneuver and negotiate in a complex environment, including the micro/macro- environment of the human host. Further, it highlights the urgent need for a concerted program to develop vaccines and other diagnosis and interventions that will eventually help prevent and treat infectious cancers, and decrease their burden on human populations. It offers graduate students and researchers a comprehensive overview of the infectious causes of cancers.
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Cai, Qiliang. \ed.\; Yuan, Zhenghong. \ed.\; Lan, Ke. \ed.\
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10.


   
    Biomarkers in Liver Disease [Electronic resource] / ed.: Patel, Vinood B., Preedy, Victor R. - 1st ed. 2017. - [S. l. : s. n.]. - 162 illus., 110 illus. in color. eReference. - ISBN 9789400776753
    Зміст:
Рубрики: Cancer research.
   Oncology  .
   Pharmacology.
   Cancer Research.
   Oncology.
   Pharmacology/Toxicology.
Анотація: There are numerous types of liver disease that may be due to toxic agents (such as alcohol or drugs), infectious agents including viruses, congenital conditions and even poor dietary patterns. It has been suggested that there are over 100 different types.  As the consequences of liver failure can be devastating it is important that appropriate diagnosis and monitoring is carried out. Much of this characterisation entails the use of biological indicators, i.e biomarkers. Biomarkers in Liver Disease embraces a holistic approach by combining detailed information on different conditions that affect the liver and the use of biomarkers. Biomarkers are described in terms of conventional, new and emerging analytes, techniques, platforms and applications. It covers the latest knowledge, trends and innovations. New platforms are described which combine advances in biomedical sciences, physics, computing and chemistry.
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Patel, Vinood B. \ed.\; Preedy, Victor R. \ed.\
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11.


   
    Melanoma Development [Electronic resource] : molecular Biology, Genetics and Clinical Application / / ed. Bosserhoff, Anja K. - 2nd ed. 2017. - [S. l. : s. n.]. - VIII, 447 p. 36 illus., 26 illus. in color. - ISBN 9783319413198
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics. Human Melanoma is a dangerous type of skin cancer affecting an increasing population, and a better understanding of its development will help in finding sophisticated targeted therapies. The second revised edition features the latest research findings and offers updates on the latest advances and potential novel melanoma therapies. It is a valuable resource for researchers and clinicians working in the fields of melanoma, cancer research and therapy as well as dermatology.
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Bosserhoff, Anja K. \ed.\
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12.


   
    Ex Vivo Engineering of the Tumor Microenvironment [Electronic resource] / ed.: Aref, Amir R., Barbie, David. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 135 p. 18 illus., 17 illus. in color. - ISBN 9783319453972
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
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Aref, Amir R. \ed.\; Barbie, David. \ed.\
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13.


    Dakubo, Gabriel D.
    Cancer Biomarkers in Body Fluids [Electronic resource] : biomarkers in Circulation / / Gabriel D. Dakubo ; . - 1st ed. 2017. - [S. l. : s. n.]. - XIX, 509 p. 20 illus. in color. - ISBN 9783319483603
Рубрики: Human genetics.
   Oncology  .
   Cancer research.
   Human Genetics.
   Oncology.
   Cancer Research.
Анотація: This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.
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Dakubo, Gabriel D. \.\
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14.


   
    Squamous cell Carcinoma [Electronic resource] : molecular Therapeutic Targets / / ed.: Warnakulasuriya, Saman., Khan, Zakir. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 281 p. 30 illus. in color. - ISBN 9789402410846
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine. The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer. Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and their therapeutic applications for targeted therapies based on clinical trials reported worldwide. This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.
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Warnakulasuriya, Saman. \ed.\; Khan, Zakir. \ed.\
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15.


   
    TRAIL, Fas Ligand, TNF and TLR3 in Cancer [Electronic resource] / ed. Micheau, Olivier. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 317 p. 40 illus., 35 illus. in color. - ISBN 9783319568058
    Зміст:
Рубрики: Cancer research.
   Cancer Research.
Анотація: This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.
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Micheau, Olivier. \ed.\
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16.


   
    Gastric Cancer Prewarning and Early Diagnosis System [Electronic resource] / ed. Cui, Daxiang. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 355 p. 174 illus., 144 illus. in color. - ISBN 9789402409512
    Зміст:
Рубрики: Cancer research.
   Biology—Technique.
   Radiology.
   Cancer Research.
   Biological Techniques.
   Diagnostic Radiology.
Анотація: The book explores recent developments in the application of nanotechnology in the early detection of gastric cancer. It discusses various aspects, such as screening for gastric cancer-associated biomarkers; establishing new ultrasensitive detection methods based on nanoparticle labeling and nanoeffects; developing a new generation of nanodevices for high-throughput examination of serum and breath biomarkers; developing multifunctional nanoprobes for targeted imaging and simultaneous therapy of gastric cancer; evaluating the biosafety of multifunctional nanoprobes; and the establishment of a pre-warning and early diagnosis system. It also presents clinical applications and prospects. The book provides a valuable reference for researchers in nanomedicine and clinicians involved in gastric cancer and radiology.
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17.


   
    Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma [Electronic resource] / ed.: Martinez-Barbera, Juan Pedro., Lilian Andoniadou, Cynthia. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 220 p. 47 illus., 32 illus. in color. - ISBN 9783319518909
    Зміст:
Рубрики: Endocrinology .
   Cancer research.
   Stem cells.
   Endocrinology.
   Cancer Research.
   Stem Cells.
Анотація: This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy. .
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Martinez-Barbera, Juan Pedro. \ed.\; Lilian Andoniadou, Cynthia. \ed.\
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18.


   
    Proteases in Physiology and Pathology [Electronic resource] / ed.: Chakraborti, Sajal., Dhalla, Naranjan S. - 1st ed. 2017. - [S. l. : s. n.]. - XV, 619 p. 97 illus., 78 illus. in color. - ISBN 9789811025136
    Зміст:
Рубрики: Human physiology.
   Molecular biology.
   Pharmaceutical technology.
   Cancer research.
   Human Physiology.
   Molecular Medicine.
   Pharmaceutical Sciences/Technology.
   Cancer Research.
Анотація: Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
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Chakraborti, Sajal. \ed.\; Dhalla, Naranjan S. \ed.\
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19.


    Asante-Duah, Kofi.
    Public Health Risk Assessment for Human Exposure to Chemicals [Electronic resource] / Kofi. Asante-Duah ; . - 2nd ed. 2017. - [S. l. : s. n.]. - XXI, 600 p. 35 illus., 8 illus. in color. - ISBN 9789402410396
    Зміст:
Рубрики: Environmental health.
   Ecotoxicology.
   Public health.
   Environmental chemistry.
   Cancer research.
   Environmental Health.
   Water and Health.
   Ecotoxicology.
   Public Health.
   Environmental Chemistry.
   Cancer Research.
Анотація: This book provides a concise, yet comprehensive overview of the many facets relating to human health risk assessments in relation to chemical exposure problems. It presents some very important tools and methodologies that can be used to address chemical exposure and public health risk management problems in a consistent, efficient, and cost-effective manner. On the whole, the book represents a collection and synthesis of the principal elements of the risk assessment process that may be used to more effectively address issues pertaining to human exposures to chemicals found in modern societies. This also includes an elaboration of pertinent risk assessment concepts and techniques/methodologies for performing human health risk assessments. Written for both the novice and the experienced, the subject matter of this book is an attempt at offering a simplified and systematic presentation of public health risk assessment methods and application tools – all these facilitated by a layout that will carefully navigate the user through the major processes involved. A number of illustrative example problems are interspersed throughout the book, in order to help present the book in an easy-to-follow, pragmatic manner.
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Asante-Duah, Kofi. \.\
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20.


   
    Personalised Medicine [Electronic resource] : lessons from Neurodegeneration to Cancer / / ed. El-Khamisy, Sherif. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 260 p. 98 illus., 52 illus. in color. - ISBN 9783319607337
    Зміст:
Рубрики: Cancer research.
   Medical genetics.
   Molecular biology.
   Cancer Research.
   Gene Function.
   Molecular Medicine.
Анотація: The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.
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El-Khamisy, Sherif. \ed.\
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