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 Знайдено у інших БД:Електронний каталог бібліотеки ЗДМФУ (4)
Формат представлення знайдених документів:
повнийінформаційнийкороткий
Пошуковий запит: <.>A=Chichirelo-Konstantynovych, K. D.$<.>
Загальна кількість знайдених документів : 1
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    Chichirelo-Konstantynovych, K. D.
    Community-acquired pneumonia associated with cytomegalovirus persistence: prevalence and peculiarities of clinical course / K. D. Chichirelo-Konstantynovych // Запорож. мед. журн. : науч.-практ. журн. - 2018. - Том 20, N 3. - С. 366-370 . - ISSN 2306-4145
MeSH-головна:
ПНЕВМОНИЯ (диагностика, лекарственная терапия, этиология)
ЦИТОМЕГАЛОВИРУС (действие лекарственных препаратов, патогенность)
АНТИТЕЛА (кровь)
Анотація: The article discusses the problem of cytomegaloviral persistence asymptomatic course among young patients with community-acquired pneumonia and in healthy population group based on specific immunoglobulins M and G appearance in blood andantibody avidity value (the duration of persistent). The connection between viral persistence and prognosis of community-acquiredpneumonia course (by pneumonia severity index in PORT) is also recognized. Aim of the scientific work is to study the prevalence of cytomegaloviral persistence among young patients with community-acquired pneumonia for optimization the plan of clinical examination and prognosis for this patient category. Materials and methods. One hundred and five patients with community-acquired pneumonia and 61 healthy individuals (aged from 18 to 44 years) were examined for cytomegaloviral biomarkers (CMV IgG, CMV IgG avidity) and by PORT-scale. Positiveresult for viral persistence was compared with gender, age subtypes and pneumonia severity index in both groups. Results. Cytomegaloviral persistence prevalence rate among patients with community-acquired pneumonia was 48.2 % versus 20.5 % among healthy individuals (P = 0.003). The patients with community-acquired pneumonia had higher CMV IgG avidityvalue (P = 0.007), it was more common for female patients (P = 0.043; χ2 = 8.164). The cytomegaloviral persistence prevalenceincreased with age (P = 0.045) and correlated with pneumonia severity index according to PORT-scale (P ‹ 0.0001). Conclusions. The patients with community-acquired pneumonia differ in significantly higher cytomegaloviral prevalence rate (P = 0.003) from the healthy respondents. This rate increases with age, negatively impacts the pneumonia prognosis (byPORT-score). The duration of cytomegaloviral persistence (based on the CMV IgG avidity value recognition) does not dependon age in both comparison groups (P › 0.05).

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