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Електронний каталог бібліотеки ЗДМФУ (17)

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Загальна кількість знайдених документів : 3
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Effect of sodium nitroprusside and S-nitrosoglutathione on pigment content and antioxidant system of tocopherol-deficient plants of arabidopsis thaliana [Текст] / N. M. Semchuk [et al.] // Укр. біохім. журн : Науково-теоретичний журнал. - 2011. - Том 83, N 6. - С. 69-79 . - ISSN 0201-8470
Анотація: Sodium nitroprusside (SNP) and S-nitrosoglutathione (GSNO) were used as a source of exogenous nitric oxide (NO) to investigate their effects on biochemical parameters and antioxidant enzyme response in leaves of wild type Columbia and tocopherol-deficient vte4 and vte1 mutant lines of Arabidopsis thaliana plants and possible tocopherol involvement in regulation of antioxidant response under NO-induced stress. SNP enhanced the activity of the enzymes, that scavenge hydrogen peroxide in leaves of all studied lines, and increased glutathione reductase and glutathione-S-transferase activity there. In addition, it decreased the intensity of lipid peroxidation in vte1 mutant line leaves. At the same time, GSNO increased the levels of protein carbonyls and inactivated enzymes ascorbate peroxidase, guaiacol peroxidase and dehydroascorbate reductase in almost all investigated plant lines. In contrast to wild type, GSNO increased superoxide dismutase activity and decreased catalase activity and chlorophyll a/b ratio in the leaves of two mutant lines. It can be assumed that tocopherols in some way are responsible for plant protection against NO-induced stress. However the mechanisms of this protection remain unknown.

Дод.точки доступу:
Semchuk, N. M.; Vasylyk, Yu. V.; Kubrak, O. I.; Lushchak, V. I.
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The effect of permeability transition pore opening on reactive oxygen species production in rat brain mitochondria [Текст] / O. V. Akopova [et al.] // Укр. біохім. журн : Науково-теоретичний журнал. - 2011. - Том 83, N 6. - С. 46-55 . - ISSN 0201-8470
Анотація: The influence of mitochondrial permeability transition pore (MPTP) opening on reactive oxygen species (ROS) production in the rat brain mitochondria was studied. It was shown that ROS production is regulated differently by the rate of oxygen consumption and membrane potential, dependent on steady-state or non-equilibrium conditions. Under steady-state conditions, at constant rate of Ca2+-cycling and oxygen consumption, ROS production is potential-dependent and decreases with the inhibition of respiration and mitochondrial depolarization. The constant rate of ROS release is in accord with proportional dependence of the rate of ROS formation on that of oxygen consumption. On the contrary, transition to non-equilibrium state, due to the release of cytochrome c from mitochondria and progressive respiration inhibition, results in the loss of proportionality in the rate of ROS production on the rate of respiration and an exponential rise of ROS production with time, independent of membrane potential. Independent of steady-state or non-equilibrium conditions, the rate of ROS formation is controlled by the rate of potential-dependent uptake of Ca2+ which is the rate-limiting step in ROS production. It was shown that MPTP opening differently regulates ROS production, dependent on Ca2+ concentration. At low calcium MPTP opening results in the decrease in ROS production because of partial mitochondrial depolarization, in spite of sustained increase in oxygen consumption rate by a cyclosporine A-sensitive component due to simultaneous work of Ca2+-uniporter and MPTP as Ca2+-influx and efflux pathways. The effect of MPTP opening at low Ca2+ concentrations is similar to that of Ca2+-ionophore, A-23187. At high calcium MPTP opening results in the increase of ROS release due to the rapid transition to non-equilibrium state because of cytochrome c loss and progressive gating of electron flow in respiratory chain. Thus, under physiological conditions MPTP opening at low intracellular calcium could attenuate oxidative damage and the impairment of neuronal functions by diminishing ROS formation in mitochondria.

Дод.точки доступу:
Akopova, O. V.; Kolchinskaya, L. I.; Nosar, V. I.; Smirnov, A. N.; Malysheva, M. K.; Mankovska, I. N.; Sagach, V. F.
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Kushkevych, I. V.
Glutathione level of Desulfovibrio desulfuricans ІМV К-6 under the influence of heavy metal salts [Текст] / I. V. Kushkevych, S. O. Hnatush, H. V. Mutenko // Укр. біохім. журн : Науково-теоретичний журнал. - 2011. - Том 83, N 6. - С. 104-109 . - ISSN 0201-8470
Анотація: Glutathione is the metal stress protector and changes of its level in the sulfate-reducing bacteria cells under the influence of heavy metal salts have not been studied yet. CdCl2, Pb(NO3)2, CuCl2, and ZnCl2 influence on the total glutathione level in cell-free extracts of sulfate-reducing bacteria Desulfovibrio desulfuricans ІМV К-6 was studied. The research has been carried out using Ellman, Lowry methods, statistical processing of the results. It was shown that the glutathione level depends on the heavy metal salts concentration in the medium. The total glutathione level was the highest under the influence of Pb(NO3)2. Other salts were also toxic to bacteria because glutathione level increased in bacterial cells after addition of these salts to the medium. On the basis of the results of our work the range of heavy metal salts influence on D. desulfuricans ІМV К-6 cells glutathione level has been formed for the first time: Pb(NO3)2 › CuCl2 › CdCl2 › ZnCl2.

Дод.точки доступу:
Hnatush, S. O.; Mutenko, H. V.
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